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  4. ozan akkus

Ozan Akkus, PhD

Principal Investigator
Professor
Department of Mechanical and Aerospace Engineering
Case School of Engineering

Research Information

Research Interests

Creates biologically active and mechanically functional tissue repair systems, and develops chemical imaging instrumentation for noninvasive biomedical and hazard diagnostics.

View the Tissue Fabrication and Mechanobiology Lab.

Publications

  • Collier, C., Hausman, B., Zulqadar, S., Din, E., Anderson, J., Akkus, O., & Greenfield, E. (2020). Characterization of a reproducible model of fracture healing in mice using an open femoral osteotomy. Bone Reports, 12
  • Isali, I., McClellan, P., Shankar, E., Gupta, S., Jain, M., Akkus, O., & Hijaz, A. (2020). PD27-05 POLARIZATION OF MACROPHAGES FROM M0 TO M2 WHEN SEEDED UPON GENIPIN-CROSSLINKED COLLAGEN MESH FOR TREATMENT OF STRESS URINARY INCONTINENCE. The Journal of Urology, 203 , e550-e551.
  • Yang, S., Sen, C., Thompson, R., Zhou, J., & Akkus, O. (2020). An in vitro Raman study on compositional correlations of lipids and protein with animal tissue hydration. Vibrational Spectroscopy, 107
  • Jung, H., & Akkus, O. (2020). Diffuse microdamage in bone activates anabolic response by osteoblasts via involvement of voltage-gated calcium channels. Journal of Bone and Mineral Metabolism, 38 (2), 151-160.
  • Unal, M., Uppuganti, S., Timur, S., Mahadevan-Jansen, A., Akkus, O., & Nyman, J. (2019). Assessing matrix quality by Raman spectroscopy helps predict fracture toughness of human cortical bone. Scientific Reports, 9 (1).
  • Learn, G., McClellan, P., Knapik, D., Cumsky, J., Webster-Wood, V., Anderson, J., Gillespie, R., & Akkus, O. (2019). Woven collagen biotextiles enable mechanically functional rotator cuff tendon regeneration during repair of segmental tendon defects in vivo. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 107 (6), 1864-1876.
  • Younesi, M., Akkus, A., & Akkus, O. (2019). Microbially-derived nanofibrous cellulose polymer for connective tissue regeneration. Materials Science and Engineering C, 99 , 96-102.
  • Zhang, F., Xie, Y., Celik, H., Akkus, O., Bernacki, S., & King, M. (2019). Engineering small-caliber vascular grafts from collagen filaments and nanofibers with comparable mechanical properties to native vessels. Biofabrication, 11 (3).
  • Chapin, K., Khalifa, A., Mbimba, T., McClellan, P., Anderson, J., Novitsky, Y., Hijaz, A., & Akkus, O. (2019). In vivo biocompatibility and time-dependent changes in mechanical properties of woven collagen meshes: A comparison to xenograft and synthetic mid-urethral sling materials: IN VIVO BIOCOMPATIBILITY AND TIME-DEPENDENT CHANGES IN MECHANICAL PROPERTIES. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 107 (3), 479-489.
  • PORTO, T., ROPERTO, R., Akkus, A., Akkus, O., Teich, S., Faddoul, F., PORTO-NETO, S., & CAMPOS, E. (2019). Effect of storage and aging conditions on the flexural strength and flexural modulus of CAD/CAM materials. Dental Materials Journal, 38 (2), 264-270.
  • Unal, M., Akkus, O., Sun, J., Cai, L., Erol, U., Sabri, L., & Neu, C. (2019). Raman spectroscopy-based water content is a negative predictor of articular human cartilage mechanical function. Osteoarthritis and Cartilage, 27 (2), 304-313.
  • Younesi, M., Wu, X., & Akkus, O. (2019). Controlled mercerization of bacterial cellulose provides tunability of modulus and ductility over two orders of magnitude. Journal of the Mechanical Behavior of Biomedical Materials, 90 , 530-537.
  • Du, J., Flanagan, C., Bensusan, J., Knusel, K., Akkus, O., & Rimnac, C. M. (2019). Raman Biomarkers Are Associated with Cyclic Fatigue Life of Human Allograft Cortical Bone. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 101 (17).
  • Learn, G., McClellan, P., Knapik, D., Cumsky, J., Webster-Wood, V., Anderson, J., Gillespie, R., & Akkus, O. (2018). Woven collagen biotextiles enable mechanically functional rotator cuff tendon regeneration during repair of segmental tendon defects in vivo: WOVEN COLLAGEN BIOTEXTILES. Journal of Biomedical Materials Research - Part B Applied Biomaterials.
  • Unal, M., Akkus, O., Sun, J., Cai, L., Erol, U., Sabri, L., & Neu, C. (2018). Raman spectroscopy-based water content is a negative predictor of articular human cartilage mechanical function. Osteoarthritis and Cartilage.
  • Li, B., Singer, N., Rosenthal, A., Unal, M., Haggins, D., Yeni, Y., & Akkus, O. (2018). Chemical characterization of Maltese-cross birefringent particles in synovial fluid samples collected from symptomatic joints. Joint Bone Spine, 85 (4), 501-503.
  • Chapin, K., Khalifa, A., Mbimba, T., McClellan, P., Anderson, J., Novitsky, Y., Hijaz, A., & Akkus, O. (2018). In vivo biocompatibility and time-dependent changes in mechanical properties of woven collagen meshes: A comparison to xenograft and synthetic mid-urethral sling materials: IN VIVO BIOCOMPATIBILITY AND TIME-DEPENDENT CHANGES IN MECHANICAL PROPERTIES. Journal of Biomedical Materials Research - Part B Applied Biomaterials.
  • Amin, A., Sabri, L., Poole, C., Baig, T., Deissler, R., Rindfleisch, M., Doll, D., Tomsic, M., Akkus, O., & Martens, M. (2018). Computational homogenization of the elastic and thermal properties of superconducting composite MgB 2 wire. Composite Structures, 188 , 313-329.
  • Jung, H., Mbimba, T., Unal, M., & Akkus, O. (2018). Repetitive short-span application of extracellular calcium is osteopromotive to osteoprogenitor cells. Journal of Tissue Engineering and Regenerative Medicine, 12 (3), e1349-e1359.
  • Lopes, F., Roperto, R., Akkus, A., Akkus, O., Palma-Dibb, R., & De Sousa-Neto, M. (2018). Effect of laser activated bleaching on the chemical stability and morphology of intracoronal dentin. Archives of Oral Biology, 86 , 40-45.
  • Unal, M., & Akkus, O. (2018). Shortwave-infrared Raman spectroscopic classification of water fractions in articular cartilage ex vivo. Journal of Biomedical Optics, 23 (1).
  • Abraham, Z., Hawley, E., Hayosh, D., Webster-Wood, V., & Akkus, O. (2018). Kinesin and dynein mechanics: measurement methods and research applications. Journal of Biomechanical Engineering, 140 (2).
  • Porto, T., Roperto, R., Akkus, A., Akkus, O., Teich, S., Faddoul, F., Porto-Neto, Sizenando de Toledo, F., & De Campos, Edson Alves, F. (2018). Effect of thermal cycling on fracture toughness of CAD/CAM materials. AMERICAN JOURNAL OF DENTISTRY, 31 (4), 205-210.
  • Unal, M., Cingoz, F., Bagcioglu, C., Sozer, Y., & Akkus, O. (2018). Interrelationships between electrical, mechanical and hydration properties of cortical bone. Journal of the Mechanical Behavior of Biomedical Materials, 77 , 23-Dec.
  • Liu, T., Premasiri, K., Sui, Y., Zhan, X., Mustafa, Haithem A. B., X., Akkus, O., Zorman, C., Gao, Xuan P. A., C., & Sankaran, R. (2018). Direct, Transfer-Free Growth of Large-Area Hexagonal Boron Nitride Films by Plasma-Enhanced Chemical Film Conversion (PECFC) of Printable, Solution-Processed Ammonia Borane. ACS APPLIED MATERIALS & INTERFACES, 10 (50), 43936-43945.
  • Webster-Wood, V., Akkus, O., Gurkan, U., Chiel, H., & Quinn, R. D. (2017). Organismal engineering: Toward a robotic taxonomic key for devices using organic materials. Science Robotics, 2 (12).
  • Li, B., Singer, N., Rosenthal, A., Unal, M., Haggins, D., Yeni, Y., & Akkus, O. (2017). Chemical characterization of Maltese-cross birefringent particles in synovial fluid samples collected from symptomatic joints.. Joint Bone Spine.
  • Akkus, A., Yang, S., Roperto, R., Mustafa, H., Teich, S., & Akkus, O. (2017). A portable fiber-optic raman spectrometer concept for evaluation of mineral content within enamel tissue. Journal of Clinical and Experimental Dentistry.
  • Younesi, M., Knapik, D., Cumsky, J., Donmez, B., He, P., Islam, A., Learn, G., McClellan, P., Bohl, M., Gillespie, R., & Akkus, O. (2017). Effects of PDGF-BB delivery from heparinized collagen sutures on the healing of lacerated chicken flexor tendon in vivo. Acta Biomaterialia, 63 , 200-209.
  • Abraham, Z., Hawley, E., Hayosh, D., Webster-Wood, V., & Akkus, O. (2017). Kinesin and dynein mechanics: measurement methods and research applications. Journal of Biomechanical Engineering.
  • Morris, V., Nimbalkar, S., Younesi, M., McClellan, P., & Akkus, O. (2017). Mechanical properties, cytocompatibility and manufacturability of chitosan: PEGDA hybrid-gel scaffolds by stereolithography. Annals of biomedical engineering, 45 (1), 286–296.
  • Cudjoe, E., Younesi, M., Cudjoe, E., Akkus, O., & Rowan, S. (2017). Synthesis and Fabrication of Nanocomposite Fibers of Collagen-Cellulose Nanocrystals by Coelectrocompaction. Biomacromolecules, 18 (4), 1259-1267.
  • Baig, T., Al Amin, A., Deissler, R., Sabri, L., Poole, C., Brown, R., Tomsic, M., Doll, D., Rindfleisch, M., Peng, X., Mendris, R., Akkus, O., Sumption, M., & Martens, M. (2017). Conceptual designs of conduction cooled MgB 2 magnets for 1.5 and 3.0 T full body MRI systems. Superconductor Science and Technology, 30 (4).
  • Islam, A., Mbimba, T., Younesi, M., & Akkus, O. (2017). Effects of substrate stiffness on the tenoinduction of human mesenchymal stem cells. Acta Biomaterialia.
  • Lopes, F., Roperto, R., Akkus, A., Akkus, O., Palma-Dibb, R., & Sousa-Neto, M. (2017). Laser-activated bleaching effect on intracoronal dentin chemical stability, morphology. Dental Materials, 33 , e1-e2.
  • Flanagan, C., Unal, M., Akkus, O., & Rimnac, C. M. (2017). Raman spectral markers of collagen denaturation and hydration in human cortical bone tissue are affected by radiation sterilization and high cycle fatigue damage. Journal of the Mechanical Behavior of Biomedical Materials, 75 , 314-321.
  • Younesi, M., Donmez, B., Islam, A., & Akkus, O. (2017). Corrigendum to "Heparinized collagen sutures for sustained delivery of PDGF-BB: Delivery profile, effects on tendon-derived cells In-Vitro" [Acta Biomater. 41 (2016) 100–109]. Acta Biomaterialia.
  • Wang, B., Sun, X., Akkus, O., & Wang, L. (2017). Elevated Solute Transport at Sites of Diffuse Matrix Damage in Cortical Bone: Implications on Bone Repair. Journal of Orthopaedic Research.
  • Amin, A., Baig, T., Deissler, R., Sabri, L., Doll, D., Tomsic, M., Akkus, O., & Martens, M. (2017). Mechanical Analysis of MgB2 Based Full Body MRI Coils Under Different Winding Conditions. IEEE Transactions on Applied Superconductivity, 27 (4), 1-5.
  • Jung, H., Mbimba, T., Unal, M., & Akkus, O. (2017). Repetitive short-span application of extracellular calcium is osteopromotive to osteoprogenitor cells. Journal of Tissue Engineering and Regenerative Medicine.
  • Islam, A., Chapin, K., Moore, E., Ford, J., Rimnac, C. M., & Akkus, O. M. (2016). Gamma Radiation Sterilization Reduces the High-cycle Fatigue Life of Allograft Bone.. Clinical orthopaedics and related research, 474 (3), 827-35.
  • Li, B., Singer, N., Yeni, Y., Haggins, D., Barnboym, E., Oravec, D., Lewis, S., & Akkus, O. (2016). A Point-of-Care Raman Spectroscopy–Based Device for the Diagnosis of Gout and Pseudogout: Comparison With the Clinical Standard Microscopy. Arthritis & Rheumatology, 68 (7), 1751–1757.
  • Alapan, Y., Younesi, M., Akkus, O., & Gurkan, U. (2016). Anisotropically Stiff 3D Micropillar Niche Induces Extraordinary Cell Alignment and Elongation. Advanced Healthcare Materials [21922640], 5 (15), 1884-1892.
  • Islam, A., Younesi, M., Mbimba, T., & Akkus, O. (2016). Collagen Substrate Stiffness Anisotropy Affects Cellular Elongation, Nuclear Shape, and Stem Cell Fate toward Anisotropic Tissue Lineage. Advanced healthcare materials, 5 (17), 2237–2247.
  • Lopes, F., Roperto, R., Akkus, A., Akkus, O., Souza-Gabriel, A., & Sousa-Neto, M. (2016). Effects of different lasers on organic/inorganic ratio of radicular dentin. Lasers in medical science, 31 (3), 415–420.
  • Younesi, M., Donmez, B., Islam, A., & Akkus, O. (2016). Heparinized collagen sutures for sustained delivery of PDGF-BB: Delivery profile and effects on tendon-derived cells In-Vitro. Acta Biomaterialia [17427061], 41 , 100-109.
  • Jiang, Y., Akkus, A., Roperto, R., Akkus, O., Li, B., Lang, L., & Teich, S. (2016). Measurement of J-integral in CAD/CAM dental ceramics and composite resin by digital image correlation. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 62 , 240-246.
  • Khalifa, A., Chapin, K., Abdelgawad, O., Anderson, J., Akkus, O., & Hijaz, A. (2016). PD36-11 BIOCOMPATIBILITY OF WOVEN COLLAGEN MESH AS A NOVEL BIOMATERIAL FOR FUTURE SLINGS.. The Journal of Urology [00225347], 195 (4).
  • Younesi, M., Goldberg, V., & Akkus, O. (2016). A micro-architecturally biomimetic collagen template for mesenchymal condensation based cartilage regeneration. Acta biomaterialia, 30 , 212–221.
  • Akkus, A., Yang, S., Akkus, O., & Lang, L. (2016). A portable confocal fiber optic raman spectrometer concept for evaluation of mineral content within enamel tissue. J Oper Esthet Dent, 1 (1), 1–5.
  • Gillespie, R., Knapik, D., & Akkus, O. (2016). Biologic and Synthetic Grafts in the Reconstruction of Large to Massive Rotator Cuff Tears. Journal of the American Academy of Orthopaedic Surgeons, 24 (12), 823–828.
  • Webster, V., Hawley, E., Akkus, O., Chiel, H., & Quinn, R. D. (2016). Effect of actuating cell source on locomotion of organic living machines with electrocompacted collagen skeleton. Bioinspiration and Biomimetics [17483182], 11 (3).
  • Donmez, B., Unal, M., Ozdemir, S., Ozturk, N., Oguz, N., & Akkus, O. (2016). Effects of losartan treatment on the physicochemical properties of diabetic rat bone. Journal of bone and mineral metabolism.
  • Akkus, A., Akkus, O., Roperto, R., & Lang, L. (2016). Investigation of Intra-and Inter-individual Variations of Mineralisation in Healthy Permanent Human Enamel by Raman Spectroscopy.. Oral health & preventive dentistry, 14 (4), 321–327.
  • Porto, T., Roperto, R., Akkus, A., Akkus, O., Porto-Neto, S., Teich, S., Lang, L., & Campos, E. (2016). Mechanical properties and DIC analyses of CAD/CAM materials. Journal of Clinical and Experimental Dentistry, 8 (5), e512.
  • Webster, V., Nieto, S., Grosberg, A., Akkus, O., Chiel, H., & Quinn, R. D. (2016). Simulating muscular thin films using thermal contraction capabilities in finite element analysis tools. Journal of the Mechanical Behavior of Biomedical Materials [17516161], 63 , 326-336.
  • Amin, A., Baig, T., Deissler, R., Yao, Z., Tomsic, M., Doll, D., Akkus, O., & Martens, M. (2016). A multiscale and multiphysics model of strain development in a 1.5 T MRI magnet designed with 36 filament composite MgB 2 superconducting wire. Superconductor Science and Technology [09532048], 29 (5).
  • Jung, H., & Akkus, O. (2016). Activation of intracellular calcium signaling in osteoblasts colocalizes with the formation of post-yield diffuse microdamage in bone matrix. BoneKEy Reports [20476396], 5
  • Alapan, Y., Younesi, M., Akkus, O., & Gurkan, U. (2016). Cell-Aligning Substrates: Anisotropically Stiff 3D Micropillar Niche Induces Extraordinary Cell Alignment and Elongation (Adv. Healthcare Mater. 15/2016). Advanced Healthcare Materials [21922640], 5 (15), 1833-1833.
  • Roperto, R., Akkus, A., Akkus, O., Lang, L., Sousa-Neto, M., Teich, S., & Porto, T. (2016). Effect of different adhesive strategies on microtensile bond strength of computer aided design/computer aided manufacturing blocks bonded to dentin. Dental research journal, 13 (2), 117.
  • Akkus, A., Akkus, A., Roperto, R., Akkus, O., Porto, T., Teich, S., & Lang, L. (2016). Evaluation of mineral content in healthy permanent human enamel by Raman spectroscopy. Journal of Clinical and Experimental Dentistry, 8 (5), e546.
  • Akkus, A., Yang, S., Akkus, O., & Lang, L. (2016). Journal of Operative and Esthetic Dentistry Volume 1, Issue 1, March 2016, Pages 1–5. Journal of Operative and Esthetic Dentistry, 1 (1), 1–5.
  • Unal, M., Jung, H., & Akkus, O. (2016). Novel Raman Spectroscopic Biomarkers Indicate That Postyield Damage Denatures Bone’s Collagen. Journal of Bone and Mineral Research.
  • Shantavasinkul, P., Akkus, O., Palomo, J., & Baumgaertel, S. (2016). Surface strain distribution of orthodontic miniscrews under load. American Journal of Orthodontics and Dentofacial Orthopedics, 150 (3), 444–450.
  • Islam, A., Bohl, M., Tsai, A., Younesi, M., Gillespie, R., & Akkus, O. (2015). Biomechanical evaluation of a novel suturing scheme for grafting load-bearing collagen scaffolds for rotator cuff repair. , 30 (7), 669-675.
  • Jung, H., Best, M., & Akkus, O. (2015). Microdamage induced calcium efflux from bone matrix activates intracellular calcium signaling in osteoblasts via L-type and T-type voltage-gated calcium channels. , 76 , 88-96.
  • Motavalli, M., Akkus, O., & Mansour, J. M. (2014). Depth-dependent shear behavior of bovine articular cartilage: relationship to structure.. Journal of anatomy, 225 (5), 519-26.
  • Unal, M., Yang, S., & Akkus, O. (2014). Molecular spectroscopic identification of the water compartments in bone.. Bone, 67 , 228-36.
  • Motavalli, M., Akkus, O., & Mansour, J. M. (2014). Depth dependent shear behavior of articular cartilage: Relationship to structure. .
  • Yang, S., Li , B., Akkus, A., Akkus, O., & Lang, L. (2014). Wide-field Raman imaging of dental lesions.. The Analyst, 139 (12), 3107-14.
  • Li , B., Yang, S., & Akkus, O. (2014). A customized Raman system for point-of-care detection of arthropathic crystals in the synovial fluid.. The Analyst, 139 (4), 823-30.
  • Tsai, A., Reich, M., Bensusan, J., Ashworth, T., Marcus, R., & Akkus, O. (2013). A fatigue loading model for investigation of iatrogenic subtrochanteric fractures of the femur.. Clinical biomechanics (Bristol, Avon), 28 (9-10), 981-7.
  • Reich, M., Kishore, V., Iglesias, R., & Akkus, O. (2013). Genipin as a sporicidal agent for the treatment of cortical bone allografts.. Journal of biomaterials applications.
  • Agcaoglu, S., & Akkus, O. (2013). Acoustic emission based monitoring of the microdamage evolution during fatigue of human cortical bone.. Journal of biomechanical engineering, 135 (8), 81005.
  • Yang, S., Li , B., Slipchenko, M., Akkus, A., Singer, K., Yeni, Y., & Akkus, O. (2013). Laser Wavelength Dependence of Background Fluorescence in Raman Spectroscopic Analysis of Synovial Fluid from Symptomatic Joints.. Journal of Raman spectroscopy : JRS, 44 (8), 1089-1095.
  • Zhong, Z., Muckley, M., Agcaoglu, S., Grisham, M., Zhao, Z., Orth, M., Lilburn, M., Akkus, O., & Karcher, D. (2012). The morphological, material-level, and ash properties of turkey femurs from 3 different genetic strains during production.. Poultry science, 91 (11), 2736-46.
  • Alfredo Uquillas, J., Kishore, V., & Akkus, O. (2012). Genipin crosslinking elevates the strength of electrochemically aligned collagen to the level of tendons.. Journal of the mechanical behavior of biomedical materials, 15 , 176-89.
  • Sun, X., Kishore, V., Fites, K., & Akkus, O. (2012). Osteoblasts detect pericellular calcium concentration increase via neomycin-sensitive voltage gated calcium channels.. Bone, 51 (5), 860-7.
  • Dodge, T., Wanis, M., Ayoub, R., Zhao, L., Watts, N., Bhattacharya, A., Akkus, O., Robling, A., & Yokota, H. (2012). Mechanical loading, damping, and load-driven bone formation in mouse tibiae.. Bone, 51 (4), 810-8.
  • Alfredo Uquillas, J., & Akkus, O. (2012). Modeling the electromobility of type-I collagen molecules in the electrochemical fabrication of dense and aligned tissue constructs.. Annals of biomedical engineering, 40 (8), 1641-53.
  • Gaharwar, A., Kishore, V., Rivera, C., Bullock, W., Wu, C., Akkus, O., & Schmidt, G. (2012). Physically crosslinked nanocomposites from silicate-crosslinked PEO: mechanical properties and osteogenic differentiation of human mesenchymal stem cells.. Macromolecular bioscience, 12 (6), 779-93.
  • Van Dyke, W., Sun, X., Richard, A., Nauman, E., & Akkus, O. (2012). Novel mechanical bioreactor for concomitant fluid shear stress and substrate strain.. Journal of biomechanics, 45 (7), 1323-7.
  • Sun, X., McLamore, E., Kishore, V., Fites, K., Slipchenko, M., Porterfield, D., & Akkus, O. (2012). Mechanical stretch induced calcium efflux from bone matrix stimulates osteoblasts.. Bone, 50 (3), 581-91.
  • Kishore, V., Bullock, W., Sun, X., Van Dyke, W., & Akkus, O. (2012). Tenogenic differentiation of human MSCs induced by the topography of electrochemically aligned collagen threads.. Biomaterials, 33 (7), 2137-44.
  • Gurkan, U., Golden, R., Kishore, V., Riley, C., Adamec, J., & Akkus, O. (2012). Immune and Inflammatory Pathways are Involved in Inherent Bone Marrow Ossification. Clinical Orthopaedics and Related Research®.
  • Kishore, V., Alfredo Uquillas, J., Dubikovsky, A., Alshehabat, M., Snyder, P., Breur, G., & Akkus, O. (2011). In vivo response to electrochemically aligned collagen bioscaffolds.. Journal of biomedical materials research. Part B, Applied biomaterials.
  • Kishore, V., Paderi, J., Akkus, A., Smith, K., Balachandran, D., Beaudoin, S., Panitch, A., & Akkus, O. (2011). Incorporation of a decorin biomimetic enhances the mechanical properties of electrochemically aligned collagen threads.. Acta biomaterialia, 7 (6), 2428-36.
  • Alfredo Uquillas, J., Kishore, V., & Akkus, O. (2011). Effects of phosphate-buffered saline concentration and incubation time on the mechanical and structural properties of electrochemically aligned collagen threads.. Biomedical materials (Bristol, England), 6 (3), 035008.
  • Gurkan, U., Krueger, A., & Akkus, O. (2011). Ossifying bone marrow explant culture as a three-dimensional mechanoresponsive in vitro model of osteogenesis. Tissue Engineering Part A, 17 (3-4), 417–428.
  • Zhong, Z., & Akkus, O. (2011). Effects of age and shear rate on the rheological properties of human yellow bone marrow.. Biorheology, 48 (2), 89-97.
  • Gurkan, U., Kishore, V., Condon, K., Bellido, T., & Akkus, O. (2011). A scaffold-free multicellular three-dimensional in vitro model of osteogenesis. Calcified tissue international, 88 (5), 388–401.
  • Song, Q., Xu, Z., Choi, S., Sun, X., Xiao, S., Akkus, O., & Kim, S. (2010). Detection of nanoscale structural changes in bone using random lasers.. Biomedical optics express, 1 (5), 1401-1407.
  • Xu, Z., Sun, X., Liu, L., Song, Q., Muckley, M., Akkus, O., & Kim, S. (2010). Spectroscopic visualization of nanoscale deformation in bone: interaction of light with partially disordered nanostructure.. Journal of biomedical optics, 15 (6), 060503.
  • Sun, X., Hoon Jeon, J., Blendell, J., & Akkus, O. (2010). Visualization of a phantom post-yield deformation process in cortical bone.. Journal of biomechanics, 43 (10), 1989-96.
  • Schilt, P., McRae, B., Akkus, O., Cordes, S., & Halum, S. (2010). An experimental model to investigate initial tracheal anastomosis strength.. The Laryngoscope, 120 (6), 1125-8.
  • Song, Q., Xiao, S., Xu, Z., Liu, L., Sun, X., Drachev, V., Shalaev, V., Akkus, O., & Kim, S. (2010). Random lasing in bone tissue.. Optics letters, 35 (9), 1425-7.
  • Gurkan, U., Gargac, J., & Akkus, O. (2010). The sequential production profiles of growth factors and their relations to bone volume in ossifying bone marrow explants. Tissue Engineering Part A, 16 (7), 2295–2306.
  • Gurkan, U., Cheng, X., Kishore, V., Uquillas, J., & Akkus, O. (2010). Comparison of morphology, orientation, and migration of tendon derived fibroblasts and bone marrow stromal cells on electrochemically aligned collagen constructs. Journal of Biomedical Materials Research Part A, 94 (4), 1070–1079.
  • Ishwar, A., Jeong, K., Panitch, A., & Akkus, O. (2009). Raman spectroscopic investigation of peptide-glycosaminoglycan interactions.. Applied spectroscopy, 63 (6), 636-41.
  • Cheng, X., Haggins, D., York, R., Yeni, Y., & Akkus, O. (2009). Analysis of crystals leading to joint arthropathies by Raman spectroscopy: comparison with compensated polarized imaging.. Applied spectroscopy, 63 (4), 381-6.
  • Meldrum, R., Gurkan, U., Kattaya, S., & Akkus, O. (2009). Osteogenic Effects of Preparations of Rat Pulmonary Alveolar Macrophages Challenged with Staphylococcus Aureus. Indiana Orthopaedic Journal, 3 , 28.
  • Wasserman, N., Brydges, B., Searles, S., & Akkus, O. (2008). In vivo linear microcracks of human femoral cortical bone remain parallel to osteons during aging.. Bone, 43 (5), 856-61.
  • Kattaya, S., Akkus, O., & Slama, J. (2008). Radioprotectant and radiosensitizer effects on sterility of gamma-irradiated bone.. Clinical orthopaedics and related research, 466 (8), 1796-803.
  • Yerramshetty, J., & Akkus, O. (2008). The associations between mineral crystallinity and the mechanical properties of human cortical bone.. Bone, 42 (3), 476-82.
  • Cheng, X., Gurkan, U., Dehen, C., Tate, M., Hillhouse, H., Simpson, G., & Akkus, O. (2008). An electrochemical fabrication process for the assembly of anisotropically oriented collagen bundles. Biomaterials, 29 (22), 3278–3288.
  • Gurkan, U., & Akkus, O. (2008). The mechanical environment of bone marrow: a review. Annals of biomedical engineering, 36 (12), 1978–1991.
  • Dziak, K., & Akkus, O. (2008). Effects of polyelectrolytic peptides on the quality of mineral crystals grown in vitro.. Journal of bone and mineral metabolism, 26 (6), 569-75.
  • Nandagawali, S., Yerramshetty, J., & Akkus, O. (2007). Raman imaging for quantification of the volume fraction of biodegradable polymers in histological preparations.. Journal of biomedical materials research. Part A, 82 (3), 611-7.
  • Ramasamy, J., & Akkus, O. (2007). Local variations in the micromechanical properties of mouse femur: the involvement of collagen fiber orientation and mineralization.. Journal of biomechanics, 40 (4), 910-8.
  • Yerramshetty, J., Lind, C., & Akkus, O. (2006). The compositional and physicochemical homogeneity of male femoral cortex increases after the sixth decade.. Bone, 39 (6), 1236-43.
  • Yeni, Y., Yerramshetty, J., Akkus, O., Pechey, C., & Les, C. (2006). Effect of fixation and embedding on Raman spectroscopic analysis of bone tissue.. Calcified tissue international, 78 (6), 363-71.
  • Akkus, O., & Belaney, R. (2005). Sterilization by gamma radiation impairs the tensile fatigue life of cortical bone by two orders of magnitude.. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 23 (5), 1054-8.
  • Akkus, O., Belaney, R., & Das, P. (2005). Free radical scavenging alleviates the biomechanical impairment of gamma radiation sterilized bone tissue.. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 23 (4), 838-45.
  • Akkus, O. (2005). Elastic deformation of mineralized collagen fibrils: an equivalent inclusion based composite model.. Journal of biomechanical engineering, 127 (3), 383-90.
  • Wasserman, N., Yerramshetty, J., & Akkus, O. (2005). Microcracks colocalize within highly mineralized regions of cortical bone tissue.. European journal of morphology, 42 (1-2), 43-51.
  • Akkus, O., Adar, F., & Schaffler, M. (2004). Age-related changes in physicochemical properties of mineral crystals are related to impaired mechanical function of cortical bone.. Bone, 34 (3), 443-53.
  • Akkus, O., Yeni, Y., & Wasserman, N. (2004). Fracture mechanics of cortical bone tissue: a hierarchical perspective.. Critical reviews in biomedical engineering, 32 (5-6), 379-426.
  • Akkus, O., Knott, D., Jepsen, K., Davy, D., & Rimnac, C. M. (2003). Relationship between damage accumulation and mechanical property degradation in cortical bone: microcrack orientation is important.. Journal of biomedical materials research. Part A, 65 (4), 482-8.
  • Akkus, O., Polyakova-Akkus, A., Adar, F., & Schaffler, M. (2003). Aging of microstructural compartments in human compact bone.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 18 (6), 1012-9.
  • Jepsen, K., Akkus, O., Majeska, R., & Nadeau, J. (2003). Hierarchical relationship between bone traits and mechanical properties in inbred mice.. Mammalian genome : official journal of the International Mammalian Genome Society, 14 (2), 97-104.
  • Akkus, O., & Rimnac, C. M. (2001). Fracture resistance of gamma radiation sterilized cortical bone allografts.. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 19 (5), 927-34.
  • Akkus, O., & Rimnac, C. M. (2001). Cortical bone tissue resists fatigue fracture by deceleration and arrest of microcrack growth.. Journal of biomechanics, 34 (6), 757-64.
  • Korkusuz, F., Akin, S., Akkus, O., & Korkusuz, P. (2000). Assessment of mineral density and atomic content of fracture callus by quantitative computerized tomography.. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 5 (3), 248-55.
  • Gursel, I., Balcik, C., Arica, Y., Akkus, O., Akkas, N., & Hasirci, V. (1998). Synthesis and mechanical properties of interpenetrating networks of polyhydroxybutyrate-co-hydroxyvalerate and polyhydroxyethyl methacrylate.. Biomaterials, 19 (13), 1137-43.
  • Akkus, O., Korkusuz, F., Akin, S., & Akkas, N. (1998). Relation between mechanical stiffness and vibration transmission of fracture callus: an experimental study on rabbit tibia.. Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, 212 (5), 327-36.
  • Komurcu, M., Akkus, O., Basbozkurt, M., Gurkan-Cavusoglu, E., & Akkas, N. (1997). Reduction of restrictive adhesions by local aprotinin application and primary sheath repair in surgically traumatized flexor tendons of the rabbit.. The Journal of hand surgery, 22 (5), 826-32.
  • Omeroğlu, H., Ateş, Y., Akkus, O., Korkusuz, F., Biçimoğlu, A., & Akkas, N. (1997). Biomechanical analysis of the effects of single high-dose vitamin D3 on fracture healing in a healthy rabbit model.. Archives of orthopaedic and trauma surgery, 116 (5), 271-4.
  • Younesi, M., Islam, A., Kishore, V., Anderson, J., & Akkus, O. (). Tenogenic Induction of Human MSCs by Anisotropically Aligned Collagen Biotextiles. Advanced Functional Materials, 24 (36), 5762-5770.

Education

PhD
Mechanical and Aerospace Engineering
Case Western Reserve University
2000
MS
Engineering Sciences
Middle East Technical University
1995
BS
Mechanical Engineering
Middle East Technical University
1993