The establishment of the new Center for Artificial Intelligence (AI) Enabling Discovery in Disease Biology (AID2B) at Case Western Reserve University School of Medicine, spearheaded by Satish E. Viswanath, PhD and Jacob Scott, MD, DPhil, will leverage AI to help understand the mysteries of disease and improve people’s health. By harnessing the potential of AI and machine learning into translational research efforts, this groundbreaking center will revolutionize the intersection of medical science, AI, and the practice of medicine.