Craig Hodges, PhD

Professor
Department of Genetics and Genome Sciences
School of Medicine
Professor
Department of Pediatrics
School of Dental Medicine
Director
Cystic Fibrosis Mouse Models Core
School of Medicine

Dr. Hodges received his B.S. in Biology from Berry College in 1996 and his Ph.D. in Genetics from Case Western Reserve University in 2002.  His graduate training was in the laboratory of Dr. Patricia Hunt where his studies focused on the genetics of chromosome segregation during meiosis and infertility using mouse models.  Dr. Hodges then undertook postdoctoral training with Dr. Steven Stice at the University of Georgia studying early embryo dysfunction of clones from nuclear transfer using pigs and cows as model systems.  Dr. Hodges returned to Case Western Reserve University to train with Dr. Terry Hassold and Dr. Patricia Hunt using mouse models to study chromosome segregation and reproduction.  In 2005, Dr. Hodges joined the laboratories of Dr. Mitchell Drumm and Dr. Mark Palmert in which he created two conditional Cftr mouse models that are currently being used to study various aspects of the disease Cystic Fibrosis.  Dr. Hodges joined the faculty of the Department of Genetics and Genome Sciences and the Department of Pediatrics at Case Western Reserve University in 2009.

Research Information

Research Projects

Cystic Fibrosis (CF) is a systemic disease affecting many parts of the body including pulmonary, gastrointestinal, pancreatic, immune, endocrine and reproductive systems.  With this in mind, we are interested in determining the extent to which specific cell types contribute to CF disease characteristics, whether the pathophysiology can be halted or reversed by CFTR functional correction and understanding the molecular mechanisms behind the physiological consequences of CFTR’s absence.  We are beginning to address these issues through the use of traditional CF mouse models as well as conditional CF mouse models that allow for the conditional inactivation or restoration of Cftr function in specific tissues, cell types as well as at specific developmental timepoints.  My laboratory is particularly interested in how the loss of CFTR leads to the intestinal dysfunction and reduced growth phenotypes associated with CF.   We have found that these two phenotypes seem to be independent of each other in the CF mouse and we are investigating this further utilizing our CF models.  In addition, we are examining how specific Cftr expressing cell types in the intestine contribute to CF intestinal dysfunction and understanding how modifier genes of intestinal dysfunction modulate disease which may lead to better treatments for CF. 
In addition to directing my lab, I am also director of the cystic fibrosis mouse models core.  The core serves a unique service to the CF research community as it is the largest creator and distributor of CF and CF-related mouse models in the world. The core maintains over 50 different CF mouse strains at any one time. The production and phenotyping of these various CF mouse strains has allowed us to distribute them to 209 investigators at 85 universities and 24 companies in 30 states in the USA as well as 15 countries since 2006. With the assistance of Dr. Ron Conlon and the CWRU Transgenic and Targeting Core, we have created 15 new CF mouse models and counting to assist the CF research community.