Publications

Foundational research has been the backbone of the institution and has led to its conception and formation. Learn more about this research and the ongoing discoveries in prestigious scientific journals below:

Related to high-throughput screening and discovery of new glial cell-targeted therapies:

 

A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity

2024

Nature Neuroscience

Benjamin L. L. Clayton, James D. Kristell, Kevin C. Allan, Erin F. Cohn, Molly Karl, Andrew D. Jerome, Eric Garrison, Yuka Maeno-Hikichi, Annalise M. Sturno, Alexis Kerr, H. Elizabeth Shick, Jesse A. Sepeda, Eric C. Freundt, Andrew R. Sas, Benjamin M. Segal, Robert H. Miller & Paul J. Tesar 

Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease

2020

Nature

Elitt MS, Barbar L, Shick E, Powers BE, Maeno-Hikitchi Y, Madhavan M, Allan KC, Nawash BS, Gevorgyan AS, Hung S, Nevin ZS, Olsen HE, Hitomi M, Schlatzer DM, Zhao HT, Swayze A, LePage DF, Jiang W, Conlon RA, Rigo F, Tesar PJ.

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Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo

2015

Nature

Najm FJ, Madhavan M, Zaremba A, Shick E, Karl RT, Factor DC, Miller TE, Nevin ZS, Kantor C, Sargent A, Quick KL, Schlatzer DM, Tang H, Papoian R, Brimacombe KR, Shen M, Boxer MB, Jadhav A, Robinson AP, Podojil JR, Miller SD, Miller RH, Tesar PJ.

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Related to identifying mechanisms of glial cell dysfunction or vulnerability in disease:

 

Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis

 2024

Cell Stem Cell

Benjamin L L Clayton  ¹ , Lilianne Barbar  ² , Maria Sapar  ² , Kriti Kalpana  ² , Chandrika Rao  ² , Bianca Migliori  ² , Tomasz Rusielewicz  ² ; NYSCF Global Stem Cell Array® Team  ² ; Daniel Paull  ² , Katie Brenner  ² , Dorota Moroziewicz  ² , Ilana Katz Sand  ³ , Patrizia Casaccia  ⁴ , Paul J Tesar  ⁵ , Valentina Fossati  ⁶

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Pervasive environmental chemicals impair oligodendrocyte development

2024

Nature Neuroscience

Erin F. Cohn, Benjamin L. L. Clayton, Mayur Madhavan, Kristin A. Lee, Sara Yacoub, Yuriy Fedorov, Marissa A. Scavuzzo, Katie Paul Friedman, Timothy J. Shafer & Paul J. Tesar 

Oligodendrocyte progenitor cell fate and function in development and disease

2021

Current Opinion in Cell Biology

Clayton BLL, Tesar PJ.

Cell type-specific intralocus interactions reveal oligodendrocyte mechanisms in MS

2020

Cell

Factor DC, Barbeau AM, Allan KC, Hu LR, Madhavan M, Hoang AT, Hazel KEA, Hall PA, Nisraiyya S, Najm FJ, Miller TE, Nevin ZS, Karl RT, Lima BR, Song Y, Sibert AG, Dhillon GK, Volsko C, Bartels CF, Adams DJ, Dutta R, Gallagher MD, Phu W, Kozlenkov A, Dracheva S, Scacheri PC, Tesar PJ, Corradin O.

Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination

2018

Nature

Hubler Z, Allimuthu D, Bederman I, Elitt MS, Madhavan M, Allan KC, Shick HE, Garrison E, T Karl M, Factor DC, Nevin ZS, Sax JL, Thompson MA, Fedorov Y, Jin J, Wilson WK, Giera M, Bracher F, Miller RH, Tesar PJ, Adams DJ.

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Explore the research below centered on advanced cellular technologies for studying glial biology:

 

Induction of myelinating oligodendrocytes in human cortical spheroids

2018

Nature Methods

Madhavan M, Nevin ZS, Shick HE, Garrison E, Clarkson-Paredes C, Karl M, Clayton BLL, Factor DC, Allan KC, Barbar L, Jain T, Douvaras P, Fossati V, Miller RH, Tesar PJ.

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Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells

2013

Nature Biotechnology

Najm FJ, Lager AM, Zaremba A, Wyatt K, Caprariello AV, Factor DC, Karl RT, Maeda T, Miller RH, Tesar PJ.

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Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells

2011

Nature Methods

Najm FJ, Zaremba A, Caprariello AV, Nayak S, Freundt EC, Scacheri PC, Miller RH, Tesar PJ.