Ongoing Research and Collaborations

Heidi Gullett, MD, MPH 

Building a Foundation for Equity Science in Community Health (KL2, Clinical and Translational Science Collaborative), Principal Investigator

Conduct a Community-Based System Dynamics evaluation to identify generalizable leverage points in an innovative equity-grounded community health improvement plan; Implement and evaluate the health impact of a novel system to screen for the social determinants of health and link patients with 211 resource navigation in community health center practices; Examine the uptake of this single item screener compared to currently used longer social determinants of health screening instruments in a national network of community health centers; Pilot test scaling a brief social determinant screening/211-linking intervention for a widespread implementation trial in a national network of community health centers

(05/1/20-04/30/25)

Primary Care as Social Capital (The Institute for Integrative Health) Principal Investigator

This project looks to 1) examine the value of primary care in cultivating social capital as a means for movement out of poverty and 2) apply both systems change and collective impact theory to propose ways to transform health care into a more integrated, equitable system

(03/01/19-12/31/23)

Long-Term Effects of COVID-19 and Health Care Delivery Changes on Health Disparity Populations Living with Multiple Chronic Conditions (National Institute on Aging)

Examine the long-term effects of the COVID-19 pandemic on health care delivery and quality for people living with multiple chronic conditions (MCC) using data from a national network of community health centers

(09/30/21 – 05/31/26)

Long-Term Effects of COVID-19-induced Health Care Delivery Changes on Patient & Workforce Processes & Outcomes in Safety Net Practices Caring for Health Disparity Populations (National Institute on Minority Health and Health Disparities)

Collaborative study to evaluate the effects of the COVID-19 pandemic on the community health center primary care workforce and on equity and quality of care

(08/21/22-04/30/27)

Green Road Wisdom of Practice Initiative (University Suburban Health Center Foundation)

This project looks to 1) To perform a direct observational study of community-based physicians. 2) Conduct an oral history of private practice 3) Conduct a study of medical students’ views of future practice

(05/15/21 – 03/31/26)

Characterize multifaceted interactions between COVID-19 and alcohol use disorder (AUD) based on real-time analysis of electronic health records of 62 million adult patients, (National Institute on Alcohol Abuse and Alcoholism)Multiple Principal Investigator

Understand how COVID-19 and AUD interact

(9/27/21-8/31/24)

An integrated reverse engineering approach toward rapid drug repositioning for Alzheimer’s disease (AD) (National Institute on Aging)

Develop an integrated drug repositioning strategy to rapidly identify repositioned anti-AD drug candidates

(09/27/17-08/31/22)

Combine computational prediction, network analysis and genetic screening in c elegans to uncover neurodegenerative causes in Alzheimer's disease (AD) (National Institute on Aging)

Understand genetic mechanism underlying AD and related dementias

(9/15/2018-6/31/2023)

Construct large-scale phenomes of disease and drugs and develop data-driven systems approaches to understand genetic links between Alzheimer's disease and Neuropsychiatric symptoms (National Institute on Aging)

Construct large-scale phenomes of disease and drugs related to AD

(09/15/18-05/31/22) (no-cost extension)

Drug repurposing for cocaine use disorder (CUD) using a combined strategy of artificial intelligence (AI)-based prediction and retrospective clinical corroboration (National Institute on Drug Abuse)

Identify repurposed candidate drugs to treat CUD

(02/01/21-02/28/24)

Clinical and Translation Science Collaborative of Cleveland (CTSC) (NIH/National Center for Advancing Translational Sciences)

This grant is aimed at providing infrastructure support for patient-based research at Case Western Reserve University and its clinical affiliated hospitals, including informatics, statistics and epidemiology, community networks, patient recruitment for clinical trials, and initiation and development of clinical research

(05/15/18 - 04/30/23)

Ohio Cardiovascular Health Collaborative (State of Ohio)

The goal of this project is to develop and disseminate cardiovascular disease best practices to primary care providers in Ohio

(04/17/19 – 03/31/23)

Peter Hovmand, PhD

Food System Resiliency for Children’s Healthy Living (CHL Food System), (USDA/National Institute of Food and Agriculture) co-Principal Investigator

Developing a system dynamics model of food systems to understand community level interventions to improve nutrition

(09/01/21-08/31/26)

Connect2CWRU (Substance Abuse and Mental Health Services Administration)

Using community-based system dynamics modeling to support PDSA quality improvement cycles

(10/01/21-9/30/24)

Nourishing Power of Food (Foundation for Food and Agricultura Research)

Study focuses on developing and testing interventions to increase nutrition equity with systems thinking applied to the evaluation component

(04/01/22-03/31/26)

Planning Grant to Develop Public Simulation Model for Improved Health Outcomes, (Google X) co-Principal Investigator

Planning grant to planning grant to develop a strategy and roadmap for developing a freely available public simulation model for improved health outcomes specifically focusing on understanding Black-White cardiovascular (CVD) disparities in the United States using Community Based System Dynamics (CBSD)

(03/30/22-03/30/24)

Intergovernmental Personnel Act (IPA) (NIH/National Cancer Institute Center for Global)

Engage in advisory role to the CGH Deputy Director and Director with specific focus training NCI leaders, researchers, and staff on systems thinking and applications relevant to developing and implementing strategies for eliminating global cancer disparities
 

(01/01/22-12/31/23)

Johnie Rose, MD, PhD

Case Comprehensive Cancer Center Support Grant (NIH/National Center for Advancing Translational Sciences)

The objectives of the Center are: 1) to improve the prevention, diagnosis, and therapy of cancer through research; 2) to stimulate and support innovative, coordinated, interdisciplinary research on cancer diagnosis, treatment, and control; 3) to develop clinical applications of research discoveries and to make these applications available as quickly as possible; and 4) to develop cancer prevention and control activities to contribute to the reduction of cancer morbidity and mortality in Northeast Ohio and the surrounding region and nation

(09/30/91-03/31/25)

Forecasting Lung Transplant Benefit: A Dynamic Risk Modeling Approach (NIH/National Heart, Lung, and Blood Institute)

The major goal of this project is improving the Lung Allocation Score (LAS) system by: 1) designing better methodologies to more accurately identify the progression of illness in a patient who is awaiting transplant, 2) predicting ideal timing of transplant to maximize the number of years gained from a transplant, and 3) evaluating different allocation strategies and their impact on individual and population level survival

(06/01/20-05/31/24)

PIPP Phase I: Comprehensive, Integrated, Intelligent System for Early and Accurate Pandemic Prediction, Prevention, and Preparation at Personal and Population Levels (National Science Foundation)

The main goal is to develop nation-wide digital infrastructure for pandemic and to develop a range of fundamental research projects that integrate micro-level granular data with population-level data to tackle the grand challenge of early and accurate pandemic prediction, prevention, and preparation at personal and population levels that will also ensure privacy and inclusion

(07/15/22-12/31/23)

Multi-Level Interventions to Reduce Caries Disparities in Primary Care Settings (NIH/National Institute of Dental and Craniofacial Research)

Implementing and assessing an intervention at the practice and provider level to increase preventive and restorative dental service utilization for children insured by Ohio Medicaid

(09/18/15-02/28/24)