Research Resources

The Clinical and Translational Science Collaborative of Cleveland provides developmental, organizational, financial, and educational support to biomedical researchers as well as opportunities for community members to participate in meaningful and valuable research.

Case Western Reserve University is the site of a Clinical and Translational Science Award (CTSA) approved for funding by the National Center for Advancing Translational Sciences (NCATS) and the National Institutes of Health (NIH) through May 2017. The goal of the Clinical and Translational Science Collaborative (CTSC) is to provide full service and integrated clinical translational research capability within the Cleveland community that will improve the health of patients in Northeast Ohio through patient based research. The CTSC also provides career development support for clinical investigators and offers research participant resources in support of technology intensive studies.

The Clinical and Translational Science Collaborative of Cleveland coordinates resources relevant to clinical research at Case Western Reserve University and its hospital affiliates, Cleveland Clinic, MetroHealth Medical Center, University Hospitals Cleveland Medical Center, and the Louis Stokes Cleveland Veterans Medical Center including three Clinical Research Unit (CRU) facilities, a successful multidisciplinary institutional KL2 program, substantial technological and statistical core facilities, and a MD-PhD program in clinical research. The infrastructure support provided will impact everyone who conducts clinical research in the partner institutions and community.

CTSC resources are easily accessed online and/or in person through the Office of the Research Concierge Service, and assure prospective input into proposals by statistics and design experts, ethicists and regulatory experts, and any other expertise that the project requires including research participant resources. The CTSC Research Participant Resources span the range of support for technology intensive studies that require the resources of the Academic Medical Centers, to local practices, and to the Cleveland community itself. These participant resources are supported by technologic cores, methodological development, community partnership resources, bioethics and regulatory experts, an office for comparative effectiveness research (CER), and an infrastructure to provide biomedical informatics.

Multimethod Cancer Outcomes Research Shared Resource delivers services to conduct population based cancer outcomes research, using population based databases, including but not limited to the Ohio Cancer Incidence Surveillance System (OCISS), Medicare, Medicaid, death certificates, the U.S. Census, national survey data, and the Healthcare Cost and Utilization Project (HCUP). 

Multimethod Cancer Outcomes Research Shared Resource has the expertise to provide assistance to researchers on appropriate research design and data source(s). They can address research questions of interest, access the appropriate database(s), and obtain the necessary data users’ agreement and IRB approvals. They also provide the analytic support to carry out a study and assist with the preparation of manuscript(s) and/or grant application.  

Multimethod Cancer Outcomes Research Shared Resource assists investigators with cutting edge methodologies for large database analysis, including:

  • integrating different data sources
  • mapping and conducting spatial analysis
  • using state-of-the-art statistical methods, including multilevel analysis, data mining, and predictive analytics

Key Services:

  • consultation on study design
    • preparation for a grant application
    • analysis of existing data
  • determine data source(s) that are most appropriate for the study
  • prepare data users agreement and obtain IRB approvals
  • obtain access to the relevant data sets
  • integrate data from different sources, as needed
  • conduct statistical analyses
  • assist investigators with preparing grant application and/or manuscript(s)

Capabilities & Expertise:

  • Multimethod Cancer Outcomes Research Shared Resource designs and performs studies on demand, including proof-of-concept studies for grant applications, or to test hypotheses related to cancer epidemiology, spatial distributions, health services research, and/or disparities
  • A data library that currently includes data from the Ohio Cancer Incidence Surveillance System (OCISS), state specific and national Healthcare Cost and Utilization Project (HCUP), as well as publicly available national survey data
  • additional data (e.g., Medicare and Medicaid data) can be obtained as needed to carry out the research questions at hand
  • the research team is well versed in:
    • understanding the strengths and weaknesses of existing data sources
    • procedures to secure data users agreement to obtain access to research identifiable files from the Centers for Medicare & Medicaid Services and other entities
    • integrating data from different sources to enhance existing data sources
    • conducting state of the art statistical techniques to carry out the analysis

A part of the U.S. Department of Health and Human Services, NIH is the largest biomedical research agency in the world. NIH’s mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability. The National Institutes of Health Medical Research Initiatives are a part of this mission.

Patient-Centered Outcomes Research Institute (PCORI) was established to fund research that can help patients and those who care for them make better informed decisions about the healthcare choices they face every day by producing and promoting high integrity, evidence based information that comes from research guided by patients, caregivers, and the broader healthcare community.

The Prevention Research Center for Healthy Neighborhoods (PRCHN) was formed in 2009 to address chronic health issues faced in disadvantaged neighborhoods in the greater Cleveland area.

The mission of the PRCHN is to foster partnerships within low resource urban neighborhoods to develop, test, and implement effective and sustainable strategies and interventions to prevent and reduce the burden of chronic disease. This is undertaken by collaborating with neighborhood residents, leaders, and community organizations in greater Cleveland to address the significant environmental and lifestyle issues that serve as barriers to good health.
Some of the initiatives taking place within the PRCHN: