Warren R. Selman, MD

Co-Investigator at University Hospitals Cleveland Medical Center: Clot Lysis Evaluating Accelerator Resolution of Intraventricular Hemorrhage Phase III (NIH Protocol CLEAR), Johns Hopkins Medical Center/NIH. June, 2010 – June, 2015.

Internal Advisory Board Member at University Hospitals Case Medical Center: Ohio Brain Tumor SPORE. National Institutes of Health, 2015. 

Co-Investigator at University Hospitals Case Medical Center: Biomarker & Phase II study of GDC-0449 for recurrent GBM. ARRA ACTNOW/National Institutes of Health, 2010 – 2013.

Site PI at University Hospitals Case Medical Center:  Carotid Occlusion Surgery Study (COSS). University of North Carolina/National Institutes of Health (NINDS), December, 2007 - November, 2012. ($20,150.00)

Principal Investigator at University Hospitals Case Medical Center: Study of Neuroprotective and Neurogenerative Effects of Amphetamine or Methamphetamine/CART from the NIH/NIDA, March, 2010 – February, 2012. ($72,000.00)

Co-Investigator at University Hospitals Case Medical Center: Intraoperative Stereotactic CT-guided Endoscopic Surgery – ICES (NIH/NINDS Protocol MISTIES-ICES).  Johns Hopkins Medical Center/NIH.  June, 2009- 2011.

Co-Investigator at University Hospitals Case Medical Center: Interventional Management of Stroke III (IMSIII).  University of Cincinnati/National Institutes of Health, 2006 – 2010.

Co-investigator at University Hospitals Case Medical Center: Double-blind, randomized, placebo-controlled study to assess efficacy and safety of clazosentan to reduce vasospasm-related and all-cause mortality in adult patients with aneurysmal subarachnoid hemorrhage treated by surgical clipping (Conscious-2), Actelion.  2009 – 2010.

Co-Investigator at University Hospitals Case Medical Center: The Cancer Genome Atlas (TCGA). SAIC Frederick Inc/National Cancer Institute, 2008 – 2010.

Principal Investigator at Case Western Reserve University School of Medicine and University Hospitals Case Medical Center: Carotid Occlusion Surgery Study - NS 42167 (COSS).  National Institutes of Health, Washington University, July 1, 2001 - 2010.

Clinical Consultant for Cleveland Medical Devices, Inc., “Untethered Home Therapy System” (Grant #1-R43-NS046976-01A1), NIH/NINDS, August 15, 2004 through August 15, 2005.

Co-Principal Investigator at University Hospitals of Cleveland, “An Open-Label, Randomized, Parallel Group Study to Confirm the Safety and Efficacy of PROCRIT® (Epoetin Alfa) Administered Perioperatively vs. the Standard of Care in Blood Conservation in Subjects Undergoing Major Elective Spinal Surgery (Protocol #PR97-19-002)”.  OrthoBiotech Corporation, September 1, 2003 through August 31, 2005. 

Co-Investigator at University Hospitals of Cleveland, “A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Effects of a Targeted Concentration of Repinotan in Patients with Acute Ischemic Stroke.”  Bayer Corporation, December 1, 2001 through November 30, 2005. 

Co-Investigator at Case Western Reserve University School of Medicine and University Hospitals of Cleveland, “Subarachnoid Hemorrhage – Mortality and Management Before and After Published Guidelines.”  American Heart Association Research Award, July 1, 2002 thru June 30, 2003.

Principal Investigator at University Hospitals of Cleveland, “Use of a Venous Catheter for Core Cooling and Rewarming for Temperature Control During Aneurysm Surgery (TCAS).” Innercool Therapies, Inc., July 1, 2000 through December 31, 2002.

Co-Investigator at Case Western Reserve University School of Medicine, “Fetal Hypoxia and Nicotine Exposure and Neonatal Dysfunction.”  Philip Morris External Research Program, May 1, 2001 through April 30, 2004.

Co-Investigator at University Hospitals of Cleveland, NIH, University of Cincinnati, “Interventional Management of Stroke.”  April 1, 2001 through March 31, 2003.

Co-Investigator at University Hospitals of Cleveland, NINDS, “Hemicraniectomy and Durotomy Upon Deterioration for Massive Hemispheric Infarcts, A Multicenter Prospective Randomized Study (HEADFIRST).”  Pilot Clinical Trial awarded funding from October 1999 through September 2002.

Primary Investigator, National Institutes of Health, “Alzheimer Proteins during Brain Metabolic Stress.”  #RO1 NS34731, September 30, 1997 through May 31, 2002. 

Co-Investigator, American Heart Association, “Mitochondrial Function in Ischemic Injury in Cortical Neurons.”  July 1, 1996 through June 30, 1998.

Co-Investigator, National Institutes of Health, “Focal Stroke:  Metabolism and pH Using Neutral Red.”  #2 RO1 NS22571-04A1, March 1, 1995 through February 28, 1998.

Primary Investigator at Case Western Reserve University, University Hospitals of Cleveland, McMasters University,  “ASA and Carotid Endarterectomy,” (WM82434).  July 18, 1994 through March 31, 1998.

Research Mentor to Anthony G. Alastra, Case Western Reserve University, University Hospitals of Cleveland, Howard Hughes Medical Institute, “Pathophysiology of Reversible Focal Ischemia:  Salvaging the Penumbra.”  June 1, 1994 through May 31, 1995.

Primary Investigator at Case Western Reserve University, University Hospitals of Cleveland, National Institutes of Health, “North American Symptomatic Carotid Endarterectomy Trial.”  #RO1 NS24456, September 1, 1992 through August 31, 1997.

Primary Investigator at Case Western Reserve University, University Hospitals of Cleveland, The Upjohn Company/University of Virginia, “Efficacy/Safety Study of Tirilizad Mesylate (U-74, 006F) in Patients with Subarachnoid Hemorrhage.”  September 1, 1992 through November 15, 1993.

Primary Investigator, National Institutes of Health, First Award, “Reversible Focal Cerebral Ischemia.”  #NEUA-1-R29, September 1, 1989 through August 31, 1994.

Primary Investigator, American Heart Association, Northeast Ohio Affiliate Grant-in-Aid Award, “New Model of Focal Chronic Cerebral Vasospasm after Subarachnoid Hemorrhage in the Rat.”  #4677, July 1, 1989 through June 30, 1990.

Primary Investigator, Case Western Reserve University Research Initiation Grant, “Subarachnoid Hemorrhage—Rat Model.”  May 1, 1987 through April 30, 1988.

Primary Investigator, American Heart Association, Northeast Ohio Affiliate Grant-in-Aid Award, “Metabolic Analysis of Focal Cerebral Ischemia.”  #4480R, January 1, 1987 through December 31, 1987.

Primary Investigator, Young Clinician Investigator Award, Research Foundation of the Association of Neurological Surgeons, “Metabolic Analysis of Focal Cerebral Ischemia.”  #4480R, January 1, 1987 through December 31, 1987.

Primary Investigator, Case Western Reserve University Biomedical Research Support Grant Program, “Metabolic Analysis of Focal Cerebral Ischemia.”  #RR-05410-24, November 1, 1985 through March 31, 1986.

Primary Investigator, American Heart Association, Northeast Ohio Affiliate Grant-in-Aid Award, “Metabolic Analysis of Focal Cerebral Ischemia.”  #4480, July 1, 1985 through January 30, 1986.