Our research encompasses a broad spectrum of RNA biology, ranging from molecular studies to systems-level analysis, and from foundational discoveries to therapeutic applications.
These areas include:
RNA in Disease and Therapeutics
RNA molecules play critical roles in the onset and progression of various diseases, and non-coding RNAs (ncRNAs) are a diverse and vital class of molecules that regulate numerous biological processes. By investigating these roles and leveraging RNA's unique properties, researchers are identifying new diagnostic markers, therapeutic targets, and expanding our view of the complexity of life at the molecular level.
- Mark Cameron
- Jeffrey Deiuliis
- J. Alan Diehl
- Mitchell Drumm
- Paul Fox (CCF)
- Xiao Li
- Hua Lou
- Michelle Longworth (CCF)
- Joseph Luna
- Barsanjit Mazumder (CSU)
- Rick Padgett (CCF)
- Ashleigh Schaffer
- Derek J. Taylor
- John 'Chip' Tilton
RNA-based Technologies and Systems Biology
The development of RNA-based tools and technologies, such as CRISPR, RNA-seq, and single-cell RNA sequencing, has revolutionized the biological sciences. By integrating RNA research with computational models, network analyses, and large-scale systems biology approaches, this area focuses on the creation, optimization, and application of groundbreaking tools to expand our understanding of RNA's role in complex biological systems and provide valuable insights into human health, disease, and the underlying principles governing life at the molecular level.
- Mark Cameron
- Xiao Li
- Joseph Luna
- Alex Miron
- John 'Chip' Tilton
RNA metabolism and gene regulation
The intricate processes that govern RNA synthesis, maturation, and turnover are essential to grasp its diverse cellular roles. Researchers in this area probe the mechanisms behind RNA's formation and subsequent processing events, such as splicing, editing, capping, polyadenylation, and decay. This multifaceted exploration is fundamental not only for basic biology but also for the design and development of RNA-focused therapeutics.
- Kristian Baker
- Paul Fox (CCF)
- Jonatha Gott
- Nathan Howell
- Anton Komar (CSU)
- Michelle Longworth (CCF)
- Hua Lou
- Rick Padgett (CCF)
- Helen Salz
- Derek J. Taylor
- John 'Chip' Tilton
- Saba Valadkhan
RNA binding proteins and post-transcriptional control
RNA-protein interactions are at the heart of numerous cellular processes, and RNA plays a crucial role in regulating gene expression. Understanding the intricate relationships between RNA and proteins, including RNA-binding proteins, and analyzing how RNA molecules control gene expression at both transcriptional and post-transcriptional levels, are essential for grasping the regulation of gene expression and uncovering novel insights into cell biology, disease, and more.
- Kristian Baker
- Jeffrey Deiuliis
- J. Alan Diehl
- Jonatha Gott
- Maria Hatzoglou
- Anton Komar (CUS)
- Xiao Li
- Hua Lou
- Joseph Luna
- Barsanjit Mazumder (CSU)
- William C. Merrick
- Ashleigh Schaffer