Faculty

RNA Center Members

CWRU

Faculty Member	Research Area
Kristian Baker, PhD	Mechanisms of the nonsense-mediated mRNA decay.
Mark Cameron, PhD	Role of interferon signaling genes and the inflammasome in regulating innate and adaptive immune responses.
Jeffrey Deiuliis, PhD	Faculty-related research aims have expanded to study human cardiometabolic disease by examining tissues and fluids from healthy and disease patients using high throughput techniques and bioinformatic approaches to identify pathway abnormalities.
J. Alan Diehl, PhD	Cell cycle regulation and ubiquitin-dependent protein degradation; integrated stress response and ncRNAs in regulation of the circadian clock and tumorigenesis.
Mitchell Drumm, PhD	Explores gene editing, metabolism, and disease severity focusing on genetic disorders inspired by the CF approach.
Wenjian Gan, PhD	Functions of protein arginine methylation on cell signaling and epigenetics in human diseases.
Jonatha M. Gott, PhD	Mechanistic studies of RNA editing in Physarum mitochondria.
Maria Hatzoglou, PhD	Molecular mechanisms of the cellular response to stresses, including inflammation and diabetes.
Nathan Howell, PhD	tRNA modifications and their essential role in cellular translation.
Emmitt R. Jolly	Regulators of schistosome gene expression and their targets
Xiao Li, PhD	RNA systems biology in precision medicine.
Fu-Sen Liang	Chemical Biology, Biochemistry, Organic, Pharmaceutical
Hua Lou, PhD	Understand alternative pre-mRNA splicing in mammals.
Joseph M. Luna, PhD	Systems biology of RNA virus infections, RNA sensing and metabolism
Helen Miranda, PhD	iPSCs developed for SBMA and ALS8 to dissect the contributions of motor neurons, astrocytes and skeletal muscles for motor neuron diseases.
Alex Miron, PhD	Biomarker discovery, transcription, signal transduction, genomics (technology development and automation) and proteomics
William C. Merrick, PhD	Mechanism and regulation of eukaryotic protein biosynthesis.
Helen Salz, PhD	We are interested in sex determination and germ cell biology
Ashleigh Schaffer, PhD	Unique functions of ubiquitously expressed proteins in human brain development and pediatric neurological disease.
William P. Schiemann	Molecular mechanisms of breast cancer metastasis, metastatic dormancy, and metastastic relapse
Alan Tartakoff, PhD	Normal organization of the nucleolus in human cells and its perturbations in malignancy.
Derek J. Taylor, PhD	Structure and molecular mechanisms of macromolecular machines involved in DNA maintenance and RNA maturation and biogenesis.
Frank Tedeschi, PhD	Research Scientist & RNA Core Manager
John 'Chip' Tilton, MD	Ability of nanoPODs loaded with therapeutic proteins to treat a variety of diseases from cancer to inborn errors of metabolism.
Saba Valadkhan, PhD	Role of the mammalian long non-coding RNAs in neurogenesis and cancer.
Sam Xiao, PhD	Molecular mechanism of pyroptosis, a highly inflammatory form of cell death; and modulation of inflammatory caspases using chemical biology approaches to target inflammatory disorders.
Yi Zhang	Molecular basis of cellular pathways important for human health and disease biology, including selective autophagy, chromatin regulation and dynamics, and biomolecular condensates

Cleveland State University

Faculty Member	Research Area
Nithya Gnanapragasam , Phd	Processes that regulate tissue proliferation and differentiation, and how dysregulation of these pathways contributes to human diseases. Our studies utilize erythroid cells as a model system.
Anton Komar, PhD	Protein synthesis, protein folding and translational control of gene expression in eukaryotic cells.
Bibo Li, PhD	Telomere functions in Trypanosoma brucei, a protozoan parasite that causes African trypanosomiasis in humans and livestock.
Barsanjit Mazumder, PhD	My laboratory at Cleveland State University is interested to study the endogenous cellular mechanisms to control inflammation.
Andrew Resnick, PhD	My research activity has two main tracks: the role of sensory cilia in cellular mechanosensation and optical probes of matter.
Girish Shukla, PhD	Noncoding RNAs and their roles in gene expression, nuclear pre-mRNA splicing, specific RNA: RNA and RNA: Protein interactions, and finally post-transcriptional control and cancer therapeutics.
Aimin Zhou, PhD	Our research has focused on investigating the molecular mechanism by which RNase L regulates the expression of these proinflammatory genes and the role of RNase L in inflammatory diseases.

Cleveland Clinic

Faculty Member	Research Area
Seth Corey, PhD	The Seth Corey lab studies bone marrow failure, myelodysplastic syndromes and myeloid malignancies.
Paul Fox, PhD	Signal transduction pathways that lead to activation of the GAIT system and the in vivo function of the pathway.
Michelle Longworth, PhD	We study the proteins that help to maintain DNA organization, and the ways by which they accomplish these important functions.
Rick Padgett, PhD	Many diseases such as certain types of cancer are either caused by or associated with mistakes in the splicing process or mutations in the splicing machinery. My lab works to understand how these errors lead to disease and how we might correct them.
Jennifer Yu, MD, PhD	The mission of the Yu lab is to improve therapy for patients with brain tumors by elucidating the molecular mechanisms driving cancer initiation and progression, and in doing so, promote rigorous science and train the next generation of scientists and physicians.
Jianjun Zhao, MD, PhD	My lab investigates the role of DNA repair pathway and non-coding RNAs in the development of cancer, drug resistant and side effect with the goal of designing new prevention and therapeutic strategies for cancer.

RNA Center Members

CWRU

Faculty Member

Research Area

Mechanisms of the nonsense-mediated mRNA decay.

Role of interferon signaling genes and the inflammasome in regulating innate and adaptive immune responses.

Faculty-related research aims have expanded to study human cardiometabolic disease by examining tissues and fluids from healthy and disease patients using high throughput techniques and bioinformatic approaches to identify pathway abnormalities.

Cell cycle regulation and ubiquitin-dependent protein degradation; integrated stress response and ncRNAs in regulation of the circadian clock and tumorigenesis.

Explores gene editing, metabolism, and disease severity focusing on genetic disorders inspired by the CF approach.

Functions of protein arginine methylation on cell signaling and epigenetics in human diseases.

Mechanistic studies of RNA editing in Physarum mitochondria.

Molecular mechanisms of the cellular response to stresses, including inflammation and diabetes.

tRNA modifications and their essential role in cellular translation.

Regulators of schistosome gene expression and their targets

RNA systems biology in precision medicine.

Chemical Biology, Biochemistry, Organic, Pharmaceutical

Understand alternative pre-mRNA splicing in mammals.

Systems biology of RNA virus infections, RNA sensing and metabolism

iPSCs developed for SBMA and ALS8 to dissect the contributions of motor neurons, astrocytes and skeletal muscles for motor neuron diseases.

Biomarker discovery, transcription, signal transduction, genomics (technology development and automation) and proteomics

Mechanism and regulation of eukaryotic protein biosynthesis.

We are interested in sex determination and germ cell biology

Unique functions of ubiquitously expressed proteins in human brain development and pediatric neurological disease.

Molecular mechanisms of breast cancer metastasis, metastatic dormancy, and metastastic relapse

Normal organization of the nucleolus in human cells and its perturbations in malignancy.

Structure and molecular mechanisms of macromolecular machines involved in DNA maintenance and RNA maturation and biogenesis.

Frank Tedeschi, PhD

Research Scientist & RNA Core Manager

Ability of nanoPODs loaded with therapeutic proteins to treat a variety of diseases from cancer to inborn errors of metabolism.

Role of the mammalian long non-coding RNAs in neurogenesis and cancer.

Molecular mechanism of pyroptosis, a highly inflammatory form of cell death; and modulation of inflammatory caspases using chemical biology approaches to target inflammatory disorders.

Molecular basis of cellular pathways important for human health and disease biology, including selective autophagy, chromatin regulation and dynamics, and biomolecular condensates

Cleveland State University

Processes that regulate tissue proliferation and differentiation, and how dysregulation of these pathways contributes to human diseases. Our studies utilize erythroid cells as a model system.

Protein synthesis, protein folding and translational control of gene expression in eukaryotic cells.

Telomere functions in Trypanosoma brucei, a protozoan parasite that causes African trypanosomiasis in humans and livestock.

My laboratory at Cleveland State University is interested to study the endogenous cellular mechanisms to control inflammation.

My research activity has two main tracks: the role of sensory cilia in cellular mechanosensation and optical probes of matter.

Noncoding RNAs and their roles in gene expression, nuclear pre-mRNA splicing, specific RNA: RNA and RNA: Protein interactions, and finally post-transcriptional control and cancer therapeutics.

Our research has focused on investigating the molecular mechanism by which RNase L regulates the expression of these proinflammatory genes and the role of RNase L in inflammatory diseases.

Cleveland Clinic

The Seth Corey lab studies bone marrow failure, myelodysplastic syndromes and myeloid malignancies.

Signal transduction pathways that lead to activation of the GAIT system and the in vivo function of the pathway.

We study the proteins that help to maintain DNA organization, and the ways by which they accomplish these important functions.

Many diseases such as certain types of cancer are either caused by or associated with mistakes in the splicing process or mutations in the splicing machinery. My lab works to understand how these errors lead to disease and how we might correct them.

The mission of the Yu lab is to improve therapy for patients with brain tumors by elucidating the molecular mechanisms driving cancer initiation and progression, and in doing so, promote rigorous science and train the next generation of scientists and physicians.

My lab investigates the role of DNA repair pathway and non-coding RNAs in the development of cancer, drug resistant and side effect with the goal of designing new prevention and therapeutic strategies for cancer.