Advances in the treatment of myelofibrosis
Cancer Network: Aaron Gerds, assistant professor of medicine at the School of Medicine, discussed advancements in the treatment of patients with myelofibrosis. “The hallmark [of myelofibrosis] is scar tissue in the bone marrow, which is the common pathologic finding that we see. Mutations that occur in the JAK-STAT signaling pathway lead to this proliferation and growth and the ultimate scarring of tissue in the marrow,” said Gerds. “Over time, that scar tissue can lead to dysfunction in the hematopoietic process, and you see low blood counts in patients.”
