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Research Impact

brain
New study provides insights into architecture of abnormal protein deposits in brain disorders
Findings provide clues to how toxic proteins clump and spread Scientists at Case Western Reserve University School of Medicine have determined the structure of protein “fibrils” linked to Lou Gehrig’s disease and other neurodegenerative disorders—findings that provide clues to how toxic proteins…
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First clinical trials set for MRI cancer detection
Case Western Reserve University-developed imaging agent for MRI prostate cancer detection gets FDA approval for safety trials, set to begin this month in Columbus The U.S. Food and Drug Administration has approved human clinical trials to test the safety of cancer-detection technology developed at…
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Ultra-high field MRI detects subtle differences in structure and function of brain’s hippocampus in people with Down syndrome
Using ultra-high field magnetic resonance imaging (MRI) to map the brains of people with Down syndrome (DS), researchers from Case Western Reserve University, Cleveland Clinic, University Hospitals and other institutions detected subtle differences in the structure and function of the hippocampus—a…
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Case Western Reserve University and Cleveland Clinic find COVID-19 variants may offer clues in predicting patient outcomes as virus evolves
Researchers collaborate on genetic study of SARS-CoV-2 mutations Since the start of the COVID-19 pandemic, mutations of SARS-CoV-2—the virus that causes COVID-19—have spread to the U.S. and a host of other countries worldwide. Recent studies suggest that current COVID-19 variants are up to 70%…
opioids
Case Western Reserve and Atelerix Life Sciences Inc. sign option license to develop new therapeutic approach to opioid crisis
Novel small molecule technology reverses life-threatening opioid-induced respiratory depression without diminishing pain relief Case Western Reserve University and Atelerix Life Sciences Inc., a Charlottesville, Virginia-based biotechnology company, have signed a two-year option to license a novel…
lab-research
International team of bioethicists and scientists suggests revisiting 14-day limit on human embryo research for potential health and fertility benefits
An international team of bioethicists and scientists, led by a researcher at Case Western Reserve University, contends it may be justified to go beyond the standing 14-day limit that restricts how long researchers can study human embryos in a dish. Going beyond this policy limit could lead to…
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Case Western Reserve’s Yolanda Fortenberry receives Hartwell Foundation Award for sickle cell disease research
One of just 12 researchers nationally chosen for biomedical study to potentially benefit children Yolanda Fortenberry Yolanda Fortenberry, an associate professor of biology at Case Western Reserve University studying possible therapies for debilitating sickle cell disease, is one of just 12…
HumanFusion
Avatar team in semifinals
Case Western Reserve-led team among 38 from 16 countries selected to compete for $10 million prize A team led by Case Western Reserve University biomedical engineer Dustin Tyler has made it a step closer to the finals in a global competition to develop an “Avatar System that will transport a…
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New formulation of existing medicines prove highly effective against drug-resistant fungus
Spread of Candida auris on skin—a source of deadly infections—can be effectively stopped, according to new Case Western Reserve University research A team of researchers from Case Western Reserve University has discovered a formulation of existing medicines that can significantly reduce the…
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New CWRU School of Medicine biophysics program partnering with U.S. Air Force research laboratory to develop biosensors for stress and fatigue
Researchers at the Case Western Reserve University School of Medicine have established the Case Center for Biomarker Structure and Integration for Sensors (BioSIS), a program to advance biosensor technologies using biophysical techniques to understand and improve sensing of markers of stress and…