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Two Studies Find Stress Reprograms Cells
In a pair of publications, researchers have shown how cells adapt to stressors—like water loss—by reprogramming their internal signaling networks. The studies describe previously unknown mechanisms that cells use to send signals between cellular machinery and avoid cell death. According to the autho...
Researchers Find Possible Markers for Earlier Diagnosis of Aggressive Form of Tongue Cancer
Squamous cell carcinoma of the tongue, also known as oral tongue cancer, is an aggressive form of cancer that generally affects older people. Patients with the disease often find it difficult to eat, swallow food, or speak. Reasons for its generally poor prognosis include late detection, before pain...
New Research Aims to Improve the Lives of Children with High Grade Glioma
Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine has been awarded a $100,000 Josh Metzger Memorial Fox Trot Grant sponsored by the Prayers From Maria Foundation, in support of pediatric neurosurgical oncology research. Violette Recinos, MD, director of pediatric...
Researchers Repurpose Immune-Activating Cytokine to Fight Breast Cancer
The most lethal form of breast cancer could have a new treatment option, according to new research out of the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine. In the Proceedings of the National Academy of Sciences, researchers showed triple-negative breast canc...
CWRU School of Medicine Researcher Receives NIH Grants to Uncover Connection between Abnormal Embryonic Brain Development and Autism
One hypothesis for how autism develops is excessive neuron production in the prenatal period, leading to a transient but significant increase in brain size in the first few years of life in about one-quarter of children with the disease. But the precise timing and cause of this overgrowth is poorly ...
CWRU School of Medicine’s Mark Griswold, PhD Elected 2017 Fellow of the National Academy of Inventors
Mark A. Griswold, PhD, a professor in the Department of Radiology at Case Western Reserve University School of Medicine, has been elected to the National Academy of Inventors 2017 Fellows Program, the highest professional distinction accorded to academic inventors. He was elected as a fellow for ha...
Finding Long Strands of RNA in Skin Development and Disease
Researchers from Case Western Reserve University School of Medicine have discovered how unusually long pieces of RNA work in skin cells. The RNA pieces, called “long non-coding RNAs” or “lncRNAs,” help skin cells modulate connective tissue proteins, like collagen, and could represent novel therapeut...
National Experts Map Out Adolescent and Young Adult (AYA) Cancer Research Agenda
Researchers at the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine, are focusing their efforts on adolescent and young adult (AYA) cancer research. More than 50 leaders from top cancer research institutions will gather this Friday, December 8, in Atlanta to ide...
Researchers Find Infectious Prions in Creutzfeldt-Jakob Disease Patient Skin
Creutzfeldt-Jakob disease (CJD)—the human equivalent of mad cow disease—is caused by rogue, misfolded protein aggregates termed prions, which are infectious and cause fatal damages in the patient’s brain. CJD patients develop signature microscopic sponge-like holes in their brains. The initial signs...
Case Western Reserve University’s Pamela Davis, Lynn Singer named 2017 AAAS Fellows
Pamela B. Davis, MD, PhD, dean of the Case Western Reserve University School of Medicine and senior vice president for medical affairs, and Lynn T. Singer, PhD, the university’s deputy provost and vice president for academic affairs, have been named fellows of the American Association for the Advanc...