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Human Sex Reversal as a Protein Numbers Game
A group of researchers from Case Western Reserve University School of Medicine have completed a comprehensive molecular analysis of a toddler who developed as a female despite having a male genetic background, termed XY sex reversal. The study identifies for the first time how the machinery for…
A Rise in Obese Pregnant Women Takes its Toll on Mother and Child
The epidemic of obesity is felt in prenatal clinics and delivery rooms around the world with a worrisome trend in high-risk pregnancies that could impact mother and child, according to Patrick M. Catalano, MD, the Dierker-Biscotti Women's Health and Wellness Professor and Director of the Center for…
Case Western Reserve Researcher Receives Major Federal Grant to Test Novel Treatments for Cystic Fibrosis and Severe Asthma
In the first major study of its kind, principal investigator Benjamin Gaston, MD, a pediatric pulmonologist and researcher at Case Western Reserve University School of Medicine and University Hospitals Rainbow Babies & Children’s Hospital, has received a five-year, $13.3 million federal grant to…
Case Western Reserve University Researchers Receive Funding for Promising Childhood Cancer Research
Two Case Western Reserve University School of Medicine researchers are receiving new funding from California-based St. Baldrick’s Foundation for promising childhood cancer research. Reshmi Parameswaran, PhD, assistant professor of hematology and oncology, was awarded $330,000 to develop safer…
Case Western Reserve Researcher Awarded Neuroscience “Big Data” Grant
A Case Western Reserve University School of Medicine researcher has received a three-year “big data” grant from the National Science Foundation that will help researchers more effectively gather, use, and share neuroscience-related data, ultimately leading to better treatments. Sharing and using…
Case Western Reserve Bioethicists Call on Organized Medicine to Support Patients Desiring Assisted Death and Their Physicians
Two Case Western Reserve University School of Medicine bioethicists are calling on organized medicine to end its refusal to provide clinical guidance regarding the care of patients actively seeking assistance in dying. Writing in the November 15, 2016 issue of the Annals of Internal Medicine (now…
Scientists Discover How Cells Put the Brakes on Protein Production
A new scientific study conducted by a team of leading geneticists has characterized how cells know when to stop translating DNA into proteins, a critical step in maintaining healthy protein levels and cell function. In the study published in Cell, researchers studied short pieces of genetic…
Scientists Discover Distant DNA Working Together to Affect Disease Risk
A person’s DNA sequence can provide a lot of information about how genes are turned on and off, but new research out of Case Western Reserve University School of Medicine suggests the 3-D structure DNA forms as it crams into cells may provide an additional layer of gene control. As long strands of…
Case Western Reserve-Led International Team Identifies Fungus in Humans for First Time as Key Factor in Crohn’s Disease
A Case Western Reserve University School of Medicine-led team of international researchers has for the first time identified a fungus as a key factor in the development of Crohn’s disease. The researchers also linked a new bacterium to the previous bacteria associated with Crohn’s. The…
In Nature Opinion Piece, Case Western Reserve Researcher Calls for Animal-Human Embryo Research to Proceed – but with Strong Animal Protections
In a World View opinion column published in Nature, a Case Western Reserve University School of Medicine researcher calls for animal-human embryo research to proceed – but only with strong animal protections in place. So-called “chimera” research raises the hope of producing human organs in…