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Case Western Reserve University Scientists Uncover Common Cell Signaling Pathway Awry in Some Types of Autism
Brain cells grow faster in children with some forms of autism due to distinct changes in core cell signaling patterns, according to research from the laboratory of Anthony Wynshaw-Boris, MD, PhD, chair of the department of genetics and genome sciences at Case Western Reserve University School of…
Case Western Reserve University Researchers Identify New Drug Cocktail to Protect Mouse Retinas, Potentially Avoiding Blindness
In microseconds, every light ray that enters the eye triggers an explosion of coordinated cellular events. Entering light rays focus on a light-sensitive tissue at the back of the eye called the retina while nearby nerve cells convert the rays into cascades of signals that travel through the optic…
Fused Genes Found in Esophageal Cancer Cells Offer New Clues on Disease Mechanisms
Despite years of research, cellular mechanisms contributing to cancers like esophageal adenocarcinoma have remained elusive. What has puzzled researchers was how genes in the healthy cells lining the esophagus turned the normal cells into malignant ones. Now, researchers from Case Western Reserve…
Case Western Reserve University Researchers Identify Protein that Delays Type 1 Diabetes Onset in New Mouse Model
A new study reveals a counterintuitive cellular strategy that may protect insulin-producing cells from destruction during type 1 diabetes. Type 1 diabetes is an autoimmune disease that accounts for about 5% of the nearly 30 million diagnosed cases of diabetes in the United States, according to the…
Fluoride Consumption Linked to Diabetes Using Mathematical Models
Water fluoridation prevents dental cavities, which are a costly public health concern. But despite the benefits supplemental water fluoridation remains a controversial subject. Some indicate it may cause long term health problems, but studies reporting side effects have been minimal or…
Researchers Restore Drug Sensitivity in Breast Cancer Tumors
A team of Case Western Reserve University School of Medicine cancer researchers has uncovered one way certain tumors resist vital medication. In the study published in Oncotarget, the researchers studied tumor biopsies collected from breast cancer patients before and after treatment with the go-to…
Scientists Keep a Molecule from Moving Inside Nerve Cells to Prevent Cell Death
Amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease) is a progressive disorder that devastates motor nerve cells. People diagnosed with ALS slowly lose the ability to control muscle movement, and are ultimately unable to speak, eat, move, or breathe. The cellular mechanisms behind ALS are…
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Is the Roberts Court pro-business? Not necessarily, according to new book by law professor
Case Western Reserve School of Law Professor Jonathan Adler and business law experts examine U.S. Supreme Court’s record on business cases At first glance, the new book Business and the Roberts Court (Oxford University Press) is a valuable read for lawyers practicing business law, and for the…
Case Western Reserve University School of Medicine Takes a Lead Role in Cleveland’s Infant Mortality Initiative
Case Western Reserve University School of Medicine will serve as a lead partner for “First Year Cleveland,” a project aimed at reducing infant mortality in Cleveland and Cuyahoga County. The project, which has been awarded more than $2.9 million from the Ohio Department of Medicaid, is a…
Case Western Reserve Researcher Receives NIH grant for HIV Research in Uganda
W. Henry Boom, MD, professor of medicine at Case Western Reserve University School of Medicine and Moses L. Joloba, MBChB, MS and PhD, dean of the School of Biomedical Sciences at Makerere University have received an HIV research training program grant from the Fogarty International Center of the…