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A Case Western Reserve University School of Medicine team received $2 million from the Patient-Centered Outcomes Research Institute (PCORI) to study a combination approach to help patients stop smoking, particularly those who are socially and economically disadvantaged. The project involves…

A multicenter team led by Case Western Reserve has demonstrated that brief exposure to a targeted therapy can tell doctors which HER2-negative patients will respond — and which should switch to another kind of treatment.  If confirmed in clinical trials, the discovery would provide physicians…

Genetics researchers from Case Western Reserve School of Medicine have identified a novel long non-coding RNA (lncRNA), dubbed DACOR1, that has the potential to stymie the growth of tumor cells in the second-most deadly form of cancer in the U.S. — colorectal cancer.  The researchers found that…

Case Western Reserve University School of Law faculty member Ayesha Bell Hardaway began reparations research as CWRU law student This year marks the 150-year anniversary of the abolition of slavery in America. Over the years, there have been numerous unsuccessful attempts to secure reparations for…

The National Institutes of Health (NIH) has awarded $2.3 million to Case Western Reserve to lead a collaborative study of how changes in food options affect residents’ nutritional choices and health over time. Called the Future of Food in Your Neighborhood Study (dubbed foodNEST), the three-year…

Case Western Reserve scientists may have uncovered a molecular mechanism that sets into motion dangerous infection in the feet and hands often occurring with uncontrolled diabetes. It appears that high blood sugar unleashes destructive molecules that interfere with the body’s natural…

Case Western Reserve University scientists have discovered that a protein called Kruppel-like Factor 4 (KLF4) controls mitochondria — the “power plants” in cells that catalyze energy production. Specifically, they determined KLF4’s pivotal role through its absence — that is, the mitochondria…

An algorithm dubbed ENVE could be the Google for genetic aberrations — and it comes from Case Western Reserve. Remember the World Wide Web before the famed search engine? The web offered extraordinary amounts of information, but no consistently reliable way to secure relevant results. Cancer…

Case Western Reserve University is one of three institutions nationwide to win federal ‘big data’ grants focused on developing ways to ensure the integrity and comparability of the reams of information the U.S. health care system collects every day. If successful, the work could create enormous new…

Case Western Reserve researchers already demonstrated that a single protein plays a pivotal role in the use of nutrients by major organs that allow for the burning of fat during exercise or regulating the heart’s contractile and electrical activity. Now they have found a new benefit of Kruppel-like…