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Leaky Gut — A Source of Non-AIDS Complications in HIV-Positive Patients
Human immunodeficiency virus (HIV) infection is no longer a fatal condition, thanks to newer medications inhibiting the retrovirus, but a puzzling phenomenon has surfaced among these patients — non-AIDS complications. Scientists at Case Western Reserve University School of Medicine have resolved…
Protective Hinge Process Enables Insulin to Bind to Cells
Since its landmark discovery in 1922, insulin has improved the health and extended the lives of more than 500 million people worldwide with diabetes mellitus. Yet the question of how this key hormone binds to its target cells in the body’s organs has posed an enduring scientific mystery. A global…
Neighborhood Connections brings a 12-foot teepee to Wade Oval Wednesday July 30
Neighborhood Connections, the small-grants and grassroots community-building program affiliated with the Cleveland Foundation, is bringing a 12-foot teepee to the WOW! Wade Oval Wednesday concert on July 30. People will have an opportunity to share their thoughts about what makes for a healthy…
Cuyahoga County High School Students Smoking at the Same Rate as Adults
Cuyahoga County high school students are smoking tobacco products at the same rate as adults in the county, according to new data from the Prevention Research Center for Healthy Neighborhoods (PRCHN) at Case Western Reserve University. In 2013, more than 22 percent, or one in five high school…
International Research Team Discovers Genetic Dysfunction Connected to Hydrocephalus
The mysterious condition once known as “water on the brain” became just a bit less murky this week thanks to a global research group led in part by a Case Western Reserve researcher. Professor Anthony Wynshaw-Boris, MD, PhD, is the co-principal investigator on a study that illustrates how the…
Bacteria Hijack Plentiful Iron Supply Source to Flourish
In an era of increasing concern about the prevalence of antibiotic-resistant illness, Case Western Reserve researchers have identified a promising new pathway to disabling disease: blocking bacteria’s access to iron in the body. The scientists showed how bacterial siderophore, a small molecule,…
Case Western Reserve University Researchers and Collaborators Receive $12.6 Million NIH Grant to Study Genetics of Alzheimer’s Disease
Researchers from Case Western Reserve University School of Medicine are part of a five-university collaboration receiving a $12.6 million, four-year grant from the National Institute on Aging (NIA), part of the National Institutes of Health (NIH), to identify rare genetic variants that may either…
Case Western Reserve University, University Hospitals Announce Collaborative Fundraising Initiative for Adolescent and Young Adult Cancer
Leaders from Case Western Reserve University and University Hospitals this evening announced a new collaborative fundraising effort focused on Adolescent and Young Adult (AYA) cancer. The news came as Char and Chuck Fowler announced their third major philanthropic commitment aimed at defeating the…
Synthetic Triterpenoids Show Promise in Preventing Colitis-Associated Colon Cancer
Researchers from Case Western Reserve and Dartmouth universities have shown that a class of small antioxidant molecules carries enormous promise for suppressing colon cancer associated with colitis. These findings, published in an early June edition of the Journal of Clinical Investigation, offer…
Long Non-coding RNAs Can Encode Proteins After All
Case Western Reserve School of Medicine scientists have made an extraordinary double discovery. First, they have identified thousands of novel long non-coding ribonucleic acid (lncRNA) transcripts. Second, they have learned that some of them defy conventional wisdom regarding lncRNA transcripts,…