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Sichun Yang, PhD
Associate ProfessorDepartment of NutritionSchool of MedicineAssistant ProfessorCenter for Proteomics and BioinformaticsSchool of MedicineAssistant ProfessorDepartment of PharmacologySchool of MedicineAssistant ProfessorDepartment of Physiology and BiophysicsSchool of MedicineMemberMolecular Oncology ProgramCase Comprehensive Cancer CenterEmail: sichun.yang@case.edu
Phone: 216.368.5793
My research is in estrogen receptor biophysics, cancer biology, and drug discovery.
Vivien C. Yee, PhD
Associate ProfessorDepartment of BiochemistrySchool of MedicineDirector of Undergraduate Programs and Vice Chair for EducationDepartment of BiochemistrySchool of MedicineAssociate ProfessorDepartment of PharmacologySchool of MedicineMemberMolecular Oncology ProgramCase Comprehensive Cancer CenterEmail: vivien.yee@case.edu
Phone: 216.368.1184
I research the determination of protein molecular structure using X-ray diffraction and correlation with function.
Dhananjay Yellajoshyula, PhD
Assistant ProfessorDepartment of NeurosciencesSchool of MedicineEmail: dxy270@case.edu
Our lab focuses on understanding the cellular and transcriptional mechanisms regulating myelination and the extra cellular matrix during development and their role in disease and injury.
Dhananjay "Dan" Yellajoshyula's Biography
Jennifer Yu, MD, PhD
Associate ProfessorDepartment of Molecular MedicineSchool of MedicineCo-LeaderDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterEmail: yuj2@ccf.org
Phone: 216.444.0852
I focus primarily on molecular mechanisms driving glioblastoma cancer initiation and progression.
Jiujiu Yu, PhD
Associate ProfessorDepartment of NutritionSchool of MedicineEmail: jxy1189@case.edu
Phone: 216.368.3956
Our long-term research goals are to 1) investigate the molecular mechanisms of chronic inflammation in obesity-related metabolic diseases and 2) identify new dietary interventions or molecular therapeutics to suppress such chronic inflammation. We are particularly interested in the contribution of the NLRP3 inflammasome and extracellular vesicles to chronic inflammation. We also actively work on dietary vesicle-like nanoparticles and their anti-inflammatory functions in the context of obesity-related diseases.
Edward Yu, PhD
ProfessorDepartment of PharmacologySchool of MedicineMemberCleveland Center for Membrane & Structural BiologyEmail: ewy5@case.edu
Phone: 216.368.5358
I investigate the structural biology of multidrug resistance trasnporters and bacterial metabolite transporters.
Yi Zhang, PhD
Assistant ProfessorDepartment of BiochemistrySchool of MedicineMemberCleveland Center for Membrane & Structural BiologyMemberMolecular Oncology ProgramCase Comprehensive Cancer CenterEmail: yi.zhang26@case.edu
Phone: 216.368.0424
Our research investigates topics at the interface of chemistry and biology, focusing on elucidating the molecular basis of cellular pathways important for human health and disease biology. We employ integrative approaches to study the structure and behavior of macromolecules, understand their functions, and then predict and validate their roles in different cellular contexts. Current research areas include selective autophagy, chromatin biology and epigenetics, and biomolecular condensates.
Youwei Zhang, PhD
ProfessorDepartment of PharmacologySchool of MedicineChairDepartment of PharmacologyGraduate Qualification CommitteeVice ChairmanCommittee for Biomedical ResearchSchool of MedicineDirectorSOM Graduate Program C3MB Cell Biology CourseSchool of MedicineMemberMolecular Oncology ProgramCase Comprehensive Cancer CenterEmail: yxz169@case.edu
Phone: 216.368.7588
My research focuses on molecular mechanisms regulating genome stability and their potential application in cancer therapy.
Peng Zhang, PhD
Assistant ProfessorDepartment of NeurosciencesSchool of MedicineEmail: pxz187@case.edu
Phone: 216.368.2064
Our laboratory combines molecular, cellular, and electrophysiological approaches with state-of-art Expansion Microscopy and 3D electron microscopy in the cultured neuron and transgenic mouse models to analyze how neurons establish their communications through a specialized unit termed “synapse”. We are particularly interested in an interdisciplinary study about the role of extracellular polysaccharide in regulating the structure and function of synapses. Elucidating these mechanisms is important for understanding how synapses develop in health and how they dysfunction in neurodevelopmental and neurodegenerative disorders.
Chen Zhao, MD, PhD
Associate ProfessorDepartment of PathologySchool of MedicineMemberImmune Oncology ProgramCase Comprehensive Cancer CenterEmail: cxz545@case.edu
Phone: 216.368.4712
We are focusing on seeking in-depth understanding of the mechanisms of hematopoietic stem/progenitor cell (HSPC) self-renewal, the interactions of HSPCs and bone marrow microenvironment, and how these become dysregulated to cause leukemia/lymphoma. Specifically, we are focusing on 1) How HSF1 specifically regulates AML stem cells; and 2) how B-myeloid conversion is regulated in a pathological context.