Assistant Professor
Department of Physiology and Biophysics
School of Medicine
We use cryo-electron microscopy (cryoEM) as the major tool for structure-guided antiviral drug discovery and vaccine design. Current focuses are human herpesviruses and hepatitis B virus.
Research Information
Research Interests
Structure-aided antiviral drug discovery and vaccine design.
We use cryo-electron microscopy (cryoEM) as the major tool for structure-aided antiviral drug discovery and vaccine design. Current interest is focused on human herpesviruses and hepatitis B virus (HBV).
Publications
- Gong D*, Dai X*, Jih J*, Liu YT*, Bi GQ, Sun R, Zhou ZH. DNA-Packing Portal and Capsid-Associated Tegument Complexes in the Tumor Herpesvirus KSHV. Cell. 2019 Aug 20;. doi: 10.1016/j.cell.2019.07.035. PubMed PMID: 31447177. (* equal contribution)
- Liu YT*, Jih J*, Dai X, Bi GQ, Zhou ZH. Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome. Nature. 2019 Jun;570(7760):257-261. doi: 10.1038/s41586-019-1248-6. PubMed PMID: 31142842. (* equal contribution)
- Dai X, Zhou ZH. Structure of the herpes simplex virus 1 capsid with associated tegument protein complexes. Science. 2018 Apr 6;360(6384). doi: 10.1126/science.aao7298. PubMed PMID: 29622628.
- Dai X*, Gong D*, Lim H, Jih J, Wu TT, Sun R, Zhou ZH. Structure and mutagenesis reveal essential capsid protein interactions for KSHV replication. Nature. 2018 Jan 25;553(7689):521-525. doi: 10.1038/nature25438. PubMed PMID: 29342139. (* equal contribution)
- Dai X, Li Z, Lai M, Shu S, Du Y, Zhou ZH, Sun R. In situ structures of the genome and genome-delivery apparatus in a single-stranded RNA virus. Nature. 2017 Jan 5;541(7635):112-116. doi: 10.1038/nature20589. PubMed PMID: 27992877.
Education
PhD
Biomedical Engineering
University of California