Translational Pathobiology Research

Primary Training Faculty Translational Pathobiology Research

  • Leslie Bruggeman headshot

    Leslie Bruggeman, PhD

    Cleveland Clinic

    Email: bruggel@ccf.org

    Phone: 216.442.8516

    Kidney

    Interests: host pathology, host genetics, virology in HIVAN; APOL1 in glomerular disease; chronic kidney diseases; renal cell biology

  • Sanjay Gupta, PhD

    Case Western Reserve University

    Urology 

    Interests: TRPC channels; role of TRPC in hyper-inflammatory states; oxidative stress and Ca2+ signaling mechanisms in ion dyshomeostasis

  • Keith McCrae headshot

    Ketih McCrae

    Cleveland Clinic

    Phone: 216.444.6833

    Hematology

    Interests: Hemophilia; hypercoag; thrombotic microangiopathies; extracellular vesicles in thrombosis; immune cell crosstalk with platelets; arterial thrombosis

  • Marvin Nieman headshot

    Marvin Nieman

    Case Western Reserve University

    Email: nieman@case.edu

    Phone: 216.368.0250

    Hematology

    Interests: Thrombin signaling through protease activated receptor 4 and mechanisms by which platelets adhere to and communicate

  • Andrew Resnick headshot

    Andrew Resnick, PhD

    Cleveland State University

    Email: a.resnick@csuohio.edu

    Phone: 216.687.2437

    Kidney

    Interests: ciliary function; optical trapping

  • Alvin Schmaier headshot

    Alvin Schmaier

    University Hospitals

    Phone: 216.539.5065

    Hematology 

    Interests: Renin angiotensin systems, extracellular vesicles in thrombosis, management of congenital & acquired hemophilia and management of hypercoagulation

  • William Shilling, PhD

    Case Western Reserve University

    Kidney

    Interests: TRPC channels; role of TRPC in hyper-inflammatory states; oxidative stress and Ca2+ signaling mechanisms in ion dyshomeostasis

  • Bing-Cheng Wang headshot

    Bing-Cheng Wang, PhD

    Case Western Reserve University

    Email: bxw14@case.edu

    Phone: 216.778.4365

    Kidney

    Interests: epithelial cell adhesion and migration

Secondary Training Faculty Participating in Collaborative Projects with investigators studying Translational Pathobiology

  • Umut Gurkan, Ph.D. Benign Hematology red blood cell structure-function and survival; crosstalk of innate immune cells with platelets and the coagulation system
  • Walter Boron, M.D., Ph.D. Kidney regulation of renal ion transport by angiotensin II; proteins sensing respiratory acidosis and alkalosis; physiological roles of gas channels
  • Anton Komar, Ph.D. Benign Hematology of protein synthesis; protein folding; translational control of gene expression
  • George Dubyak, Ph.D. Benign Hematology role of gasdermin in cell death
  • Evi Stavrou, M.D. Benign Hematology Factor XII functions in diabetic skin wound healing; crosstalk of innate immune cells with platelets and the coagulation system
  • Jun Qin, PhD. Benign Hematology atomic-level visualization of protein-protein interactions in thrombosis and cardiac failure
  • Thomas Gerken, Ph.D. Benign Hematology O-linked glycan impact on protein structure