The Center for Mitochondrial Research and Therapeutics (CMRT) at Case Western Reserve University School of Medicine focuses on understanding mitochondrial dysfunction and its impact on various diseases, including neurodegenerative disorders, cancer, and cardiovascular conditions.
CMRT researchers employ multidisciplinary approaches to investigate mitochondrial biology at both molecular and cellular levels, aiming to uncover new insights that drive therapeutic advancements. By leveraging collaborative efforts and cutting-edge technologies, the center is committed to developing mitochondria-targeted therapies and translating scientific discoveries into effective treatments.
The CMRT promotes interdisciplinary and programmatically focused research across departments, advancing clinical and translational studies that align with our core research priorities:
- Cancer
- Immunity, immunotherapy, and infectious diseases
- Emerging infections and global health
- Therapeutic discovery and development
- Neurological and psychiatric disorders
- Human genetics
- Physiological disease mechanisms
- Molecular structure
- Metabolic disorders
Mitochondrial Research Core
The Mitochondrial Research Core was recently established to provide expertise and access to advanced experimental approaches that support mitochondrial research projects in the School of Medicine and partner institutions. Specifically, the core provides services to examine the composition and function of mitochondrial protein complexes.
High-end instrumentation is available to assess cellular respiration in cells and tissues. Additionally, the core offers resources to measure electron transport chain (ETC) activity in isolated complexes. The core is available to consult on all aspects of mitochondrial biology, including cellular imaging, organelle ultrastructure and various biophysical methods to evaluate numerous aspects of mitochondrial biology.