The National Center for Regenerative Medicine (NCRM) supports investigators conducting innovative research translating into cell-based therapies and technologies.
NCRM’s comprehensive bench-to-bedside approach requires partnering with researchers and institutions to support programs in the areas of:
- Basic research
- Clinical research
- Biomedical/tissue engineering research
Using stem cells to regenerate new tissue in diseased organs, instead of using drugs or devices, represents a new paradigm in biomedical research. NCRM’s collaborative partnerships have advanced research discoveries and therapeutic uses of stem cells for the following:
- Cardiovascular disease
- Adult stem cell transplantation
- Cancer
- Genetic disorders
- Musculoskeletal conditions
- Neurodegenerative conditions
| Investigator | Institution | Cell Type | Disease Target |
|---|---|---|---|
|
A. Sloan, S. Gerson |
UHCMC/CWRU | Autologous HPCs | Advanced Malignancies |
|
H. Lazarus |
UHCMC/CWRU | Allogeneic MSCs | GVHD |
|
S. Ellis, D. Simon |
CCF, UHCMC | Autologous MNCs | Acute MI and Heart Failure |
|
A. Sloan, L. Metheny, S. Gerson |
UHCMC/CWRU, NIH | Autologous HPCs | Glioblastoma |
|
J. Cohen |
CCF | Autologous MSCs | Multiple Sclerosis |
|
M. deLima, L. Metheny |
UHCMC/CWRU | Allogeneic MSCs | Leukemia |
|
J. Miller |
UHCMC |
Gene modified allogenic MSCs | Stroke |
|
J. Chmiel |
UHCMC/CWRU | Allogeneic MSCs | Cystic Fibrosis |
|
J. Baar |
UHCMC/CWRU | Autologous dendritic cell vaccine | Breast Cancer |
|
M. Murphy |
Indiana University | Allogeneic MSCs | Aortic Aneurysm and Limb Ischemia |
|
N. Singer |
Metro | Allogeneic MSCs | Rheumatoid Arthritis |
|
P. Caimi |
UHCMC/CWRU | Autologous CD19 CAR-T | Lymphoma |
|
F. Otegbeye, D. Wald |
UHCMC/CWRU | Allogeneic NK cells | Heme Malignancies and Colorectal Cancer |
|
J. Jacobson |
UHCMC/CWRU, U Cincinnati, UCSF | Autologous gene edited T cells | HIV |
|
A. Lightner |
CCF | Allogeneic MSCs | Inflammatory Bowel |
|
B. Tomlinson |
UHCMC/CWRU | Autologous CD19 CAR-T | Leukemia, Lymphoma |
|
S. Deeks |
UCSF, UC Davis | Autologous duo CAR-T | HIV |
|
J. Voos |
UHCMC | Autologous MSCs | Osteoarthritis and Chondral Defects |
|
P. Caimi, L. Metheny |
CCF, UHCMC | Autologous BAFF CAR-T | Lymphoma, Multiple Myeloma |
|
G. Deng, D. Wald |
UHCMC, CCF, U Iowa | Autologous ultra fast CAR-T | Lymphoma |