Clinical Trials

2013-2014 Trials

The National Center for Regenerative Medicine (NCRM) researchers are conducting ground-breaking regenerative medicine and stem cell therapy clinical trials. NCRM helps investigators with developing a clinical trial to investigate the efficacy and safety of cellular therapies.

Trials performed or open in 2013-2014

O6-benzylguanine (BG) and Temozolomide (TMZ) therapy of glioblastoma multiforme (GBM) with infusion of autologous P140KMGMT+ hematopoietic progenitors to protect hematopoiesis Drug resistance gene transfer for glioma
Investigator: Andrew Sloan, SCC

A Phase I study to assess the feasibility, safety, and tolerability of autologous mesenchymal stem cell transplantation in patients with relapsing forms of Multiple Sclerosis Autologous MSC transplantation in Multiple Sclerosis
Investigator: Jeffrey Cohen, CCF

Adipose-derived regenerative cells in the treatment of patients with chronic ischemia heart disease not amenable to surgical intervention or revascularization Adipose-derived cells for chronic ischemia heart disease
Investigator: Marco Costa, MD UHCMC
Sponsor: Cytori

Double-blind, randomized, placebo-controlled, Phase 2 safety and efficacy trial of Multistem® in adults with ischemic stroke Multistem® for ischemic stroke 
Investigator: Cathy Sila, MD UHCMC
Sponsor: Athersys

Pilot trial of Type I polarized autologous dendritic cell vaccine incorporating tumor blood vessel antigen-derived peptides in patients with metastatic breast cancer Dendritic Cell Vaccine for Metastatic Breast 
Investigator: Joseph Baar, MD SCC

Support of Seidman Cancer Center Stem Cell Transplantation Program clinical trials using standard of care cell therapy products General use of general stem cell products 
Investigator: Marcos DeLima, Program Director

Pending Clinical Trials

Phase II multicenter trial of single autologous hematopoietic cell transplant followed by lenalidomide maintenance for multiple myeloma with or without vaccination with dendritic cell/ myeloma fusions 
Dendritic Cell Vaccine for Multiple Myeloma
Investigator: Hillard Lazarus, MD SCC

Phase I human clinical trial of adoptive immunotherapy of ex vivo expanded autologous T cells in patients with advanced melanoma. Adoptive Immunotherapy in patients with advanced melanoma
Investigator: Julian Kim, MD SCC

Percutaneous image guided delivery of autologous bone marrow derived mesenchymal stem cells for the treatment of symptomatic degenerated intervertebral disc disease MSCs for Intervertebral Disc Degeneration
Investigator: Salim Hayak, MD Anesthesiology