Clinical Trials

NCRM researchers are conducting ground-breaking regenerative medicine and stem cell therapy clinical trials. Center experts help investigators develop clinical trials to investigate the efficacy and safety of cellular therapies.

Open Cellular Therapy Clinical Trials

CASE 3113: Pilot Trial of a Type I-Polarized Autologous Dendritic Cell Vaccine Incorporating Tumor Blood Vessel Antigen-Derived Peptides in Patients with Metastatic Breast Cancer
Investigator: Joseph Baar, MD

CASE 1Z14: Intra-Osseous Co-Transplant of Cord Blood and Mesenchymal Stomal Cells: A Feasibility Study
Investigators: Marcos de Lima, MD and Leland Metheny, MD

CASE 16Z13: Infusion of CD34+ Enriched, T Cell Depleted Hematopoietic Stem Cell Grafts
Investigator: Paolo Caimi, MD

CASE 2Z16: Phase I Trial of Universal Donor NK Cell Therapy in Combination With ALT803
Investigators: Foleshade Otegbeye, MD and David Wald, MD PhD

CASE 2417: AntiCD19 Chimeric Antigen Receptor T Cells for Relapsed or Refractory Non Hodgkin Lymphoma
Investigators: Paolo Caimi, MD and Marcos de Lima, MD

Safety and Tolerability Study of Allogeneic Mesenchymal Stem Cell Infusion in Adults With Cystic Fibrosis (CEASE-CF)
Investigator: Erica A. Roesch, MD

Mesenchymal Stem Cells in Early Rheumatoid Arthritis
Investigator: Nora Singer, MD

Pending Cellular Therapy Clinical Trials

CASE 1A16: Dendritic Cell DKK1 Vaccine for Monoclonal Gammopathy and Stable or Smoldering Myeloma
Investigator: Ehsan Malek, MD

Mesenchymal Stem Cells for Lumbar Degenerative Disc Disease
Investigator: Melinda M. Lawrence, MD

CCR5-modified CD4+ T Cells for HIV Infection (TRAILBLAZER)
Investigator: Benigno Rodriguez, MD and Rafick-Pierre Sékaly, PhD

Impact of Mesenchymal Stem Cells in Knee Osteoarthritis
Investigator: James E. Voos, MD

06-benzylguanine (BG) and Temozolomide (TMZ) Therapy of Glioblastoma Multiforme (GBM) in Patients with MGMT Positive Tumors with Infusion of Autologous P140KMGMT+ Hematopoietic Progenitors to Protect Hematopoiesis
Investigators: Andrew Sloan, MD and Stan Gerson, MD