Medicine's Kishore Guda discover possible inherited mutation behind esophageal cancer

Cleveland researchers discover possible inherited mutation behind esophageal cancer

cleveland.com: Kishore Guda, associate professor in the Department of Pathology and GMS-Oncology at the School of Medicine, said the VSIG10L gene acts as a “quality control system” for the esophageal lining. When defective, cells don’t mature properly, weakening the barrier and allowing bile acid damage that raises Barrett’s esophagus risk. He said the discovery enables earlier screening and prevention to reduce cancer deaths.