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How do Interactions between Gut Bacteria and Fungi Exacerbate Crohn’s Disease?
Scientists have known that bacteria in the gut, along with environmental and genetic factors, contribute to the debilitating intestinal ailment of Crohn’s disease (CD). But in 2016, Mahmoud A Ghannoum, PhD, FAAM, FIDSA, professor and director of the Center for Medical Mycology at Case Western…
New, High-Resolution Images Reveal Clues to Improve Anti-Nausea Drugs for Cancer Patients
A new study using a special type of electron microscope using samples cooled to extremely cold temperatures provides critical information for drug developers seeking to reduce nausea and vomiting side effects of cancer treatments. Published in Nature Communications, the study offers a glimpse into…
Mosquito Surveillance Uncovers New Information about Malaria Transmission in Madagascar
Riley Tedrow, PhD, a medical entomologist at Case Western Reserve University School of Medicine, has uncovered new findings about malaria transmission in Madagascar. In a recent study published in PLoS Neglected Tropical Diseases, he also describes real-world application of an effective mosquito…
Keeping Do-It-Yourself Gene Science Safe
While federal and professional regulatory systems monitor genetic-editing experiments in university and corporate labs, most research conducted outside of these settings lacks formal oversight. Now, two Case Western Reserve University faculty members have received a two-year grant to provide…
Combining Antibiotics, Researchers Deliver One-Two Punch against Ubiquitous Bacterium
By combining two well-established antibiotics for the first time, a scientific team led by Case Western Reserve University School of Medicine and Louis Stokes Cleveland VA Medical Center has delivered a “double whammy” against the pervasive Pseudomonas aeruginosa, a potentially deadly form of…
Drug to Treat Malaria Could Mitigate Hereditary Hearing Loss
The ability to hear depends on proteins to reach the outer membrane of sensory cells in the inner ear. But in certain types of hereditary hearing loss, mutations in the protein prevent it from reaching these membranes. Using a zebrafish model, researchers at Case Western Reserve University School…
Drug to Treat Malaria Could Mitigate Hereditary Hearing Loss
The ability to hear depends on proteins to reach the outer membrane of sensory cells in the inner ear. But in certain types of hereditary hearing loss, mutations in the protein prevent it from reaching these membranes. Using a zebrafish model, researchers at Case Western Reserve University School…
“Giving Kids Hope” Event Benefits Research on Genetic Disorders Affecting Children
Case Western Reserve University School of Medicine will host the fourth annual Giving Kids Hope benefit to help fund research in pediatric genetic disorders, on Saturday, June 8, at 6 p.m. The exciting evening will take place at the newly renovated Agora Theatre and Ballroom, and will be emceed by…
Cleveland Researchers Recruiting for Alzheimer’s Disease Clinical Trial
Case Western Reserve University School of Medicine and University Hospitals (UH) Cleveland Medical Center have enrolled their first participant in a new clinical research study evaluating the potential benefits of an investigational medicine for people with early onset Alzheimer’s disease. The…
Key Drug Target Shown Assembling in Real-Time
Over one-third of all FDA-approved drugs act on a specific family of proteins: G-protein coupled receptors (GPCRs). Drugs to treat high blood pressure, asthma, cancer, diabetes and myriad other conditions target GPCRs throughout the body—but a recent study shows what happens next. In results…