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Coenzyme A Plays Leading Role in Nitric Oxide Function So Essential to Cell Metabolism
Case Western Reserve and University Hospitals (UH) Case Medical Center researchers and physicians have discovered that the molecule known as coenzyme A plays a key role in cell metabolism by regulating the actions of nitric oxide. Cell metabolism is the ongoing process of chemical transformations…
Researchers Identify New Gene Mutations Linked to Colorectal Cancer in African American Patients
Case Comprehensive Cancer Center researchers have identified new gene mutations unique to colon cancers in African Americans – the population with the highest incidence and death rates of any group for this disease.  This discovery – namely, that colorectal cancers appear different on a molecular…
Cancer Treatment Potential Discovered in Gene Repair Mechanism
Case Western Reserve researchers have identified a two-pronged therapeutic approach that shows great potential for weakening and then defeating cancer cells. The team’s complex mix of genetic and biochemical experiments unearthed a way to increase the presence of a tumor-suppressing protein which,…
Case Western Reserve University/University Hospitals AIDS Clinical Trials Unit Launches Outreach to Enlist More Women in Clinical Trials
The Case Western Reserve University/University Hospitals (UH) AIDS Clinical Trials Unit has a new initiative to reach out to women in Northeast Ohio regarding the critical need for them to participate in HIV-related clinical trials. The initiative, titled “You can make a difference” will include…
Case Western Reserve Scientists Find Key to Vitamin A Metabolism
Researchers at Case Western Reserve University School of Medicine have uncovered the mechanism that enables the enzyme Lecithin: retinol acyltransferase (LRAT) to store vitamin A — a process that is indispensable for vision. Their findings appeared in the Nov. 10 edition of the online…
Case Western Reserve to Lead $27.3 Million Federal Grant for Sudden Unexpected Death in Epilepsy (SUDEP)
Case Western Reserve is one of two universities in the country selected to lead a $27.3 million international effort to identify the causes of a mysterious and deadly phenomenon that strikes people with epilepsy without warning. For the past several years, federal health officials have explored…
Peptide Shows Great Promise for Treating Spinal Cord Injury
Case Western Reserve scientists have developed a new chemical compound that shows extraordinary promise in restoring function lost to spinal cord injury. The compound, which the researchers dubbed intracellular sigma peptide (ISP), allowed paralyzed muscles to activate in more than 80 percent of…
Researchers Characterize a Protein Mutation that Alters Tissue Development in Males Before Birth
Case Western Reserve researchers have identified a protein mutation that alters specific gender-related tissue in males before birth and can contribute to the development of cancer as well as other less life-threatening challenges. The discovery marks the latest in a series of findings related to…
Case Western Reserve Malaria Expert Named One of 100 Leading Global Thinkers for 2014
Case Western Reserve malaria specialist Brian T. Grimberg, PhD, is among Foreign Policy magazine’s 100 Leading Global Thinkers of 2014 being honored this evening in Washington, DC. Grimberg of the Center for Global Health and Diseases at Case Western Reserve University School of Medicine will…
Law research article paints dismal picture for litigation against greenhouse gas emitters
School of Law professor has analyzed data from 178 environmental lawsuits Legal attempts to deter major emitters of environment-damaging greenhouse gases (GHGs) have been ineffective and are unlikely to have much effect for years, a Case Western Reserve School of Law professor concludes in…