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Fabio Cominelli, M.D., Ph.D.

Departments of Medicine and Pathology

Wearn 253A
(216) 844-7344


Dr. Cominelli graduated in Literature from Liceo Classico Galileo in Florence, Italy in 1976. He completed his M.D. at the University of Florence in 1983, followed by his Ph.D. in Cell Biology in 1991. He went on to complete his Residency in Internal Medicine at the University of Florence and is presently a Professor in the Departments of Medicine and Pathology of CWRU and Director of the CWRU/UH Digestive Health Center.


Crohn's Disease, General GI, Inflammatory Bowel Disease, Ulcerative Colitis.


Pizarro TT, Pastorelli L, Bamias G, Garg RR, Reuter BK, Mercado JR, Chieppa M, Arseneau KO, Ley K, Cominelli F. SAMP1/YitFc mouse strain: A spontaneous model of Crohn's disease-like ileitis. Inflamm Bowel Dis. 2011 May 6. doi: 10.1002/ibd.21638. [Epub ahead of print]

Cominelli F Arseneau K Blumberg R Stenson W and Pizarro T 2009 The mucosal immune system & gastrointestinal inflammation.In: Yamada’s Textbook of Gastroenterology.5th Edition (Ed Yamada) 133-168.

Rowlett, RM, Chrestensen CA, Nyce M, Harp MG, Pelo JW, Cominelli F, Erns PBt, Pizarro TT, Sturgill TW, and Worthington MT. 2008. MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages. Am. J. Physiol. Gastrointest. Liver Physiol. 294(2): G452-G459.

Ho, J, Kurtz C, Naganuma M, Ernst P, Cominelli F, Rivera-Nieves J. 2008. A CD8+/CD103high cell subset regulates TNF-mediates chronic murine ileitis. J. Immonol. 180:2573-80.

Bamias, G., Okazawa A, Rivera-Nieves J, Arseneau KO, De La Rue SA, Pizarro TT, and Cominelli F. 2007. Commensal bacteria exacerbate intestinal inflammation but are not essential for the development of murine ileitis. J. Immunol. 178:1809-1818.

Additional Publications