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Welcome to campus

Visit Case Western Reserve University's uniquely urban campus, located in the heart of Cleveland's cultural hub, University Circle. Plan your trip:

Jonathan Stamler, M.D.


Director, Institute for Transformative Molecular Medicine
Professor of Medicine

jss156@case.edu
Wolstein Research Building 5542
(216) 368-5726


Biography

Dr. Stamler completed his undergraduate studies at Brandeis University, earned his medical degree from Mount Sinai School of Medicine, and completed his medical residency and fellowship training in both cardiology and pulmonary medicine at Harvard Medical School and the Brigham and Women’s Hospital.

Research

Redox-based cellular regulation and signal transduction, and in particular the role of protein S-nitrosylation.

Publications

Savidge TC, Urvil P, Oezguen N, Kausar A, Choudhury A, Acharya V, Pinchuk I, Torres AG, English RD, Wiktorowicz JE, Leoffelholz M, Kumar R, Shi L, Nie W, Feng H, Braun W, Herman B, Stamler JS, Pothoulakis C.  Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins. Nature Med 2011, in press.

Stamler JS, Hess DT.  Nascent nitrosylases.  Nature Cell Biol 2010; 12(11): 1024-1026.

Xie L, Xiao K, Whalen EJ, Forrester MT, Freeman RS, Fong G, Gygi SP, Lefkowitz RJ, Stamler JS.  Oxygen-regulated beta2-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.  Science Signaling 2009; 2(78): ra33. 

Benhar M, Forrester MT, Hess DT, Stamler JS.  Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins.  Science 2008; 320: 1050-1054.

Whalen EJ, Foster MW, Matsumoto A, Ozawa K, Violin JD, Que LG, Benhar M, Keys JR, Koch WJ, Daaka Y, Lefkowitz RJ, Stamler JS.  Regulation of b-adrenergic receptor signaling by S-nitrosylation of G protein-coupled receptor kinase 2.  Cell 2007; 129(3): 511-522.

Additional Publications