Publications

At the Case Biomanufacturing and Microfabrication Lab, we're proud to regularly publish our work. Take a look through our publications. 

2016

• 3-D Microwell Array System for Culturing Virus Infected Tumor Cells 
  El Assal R., U. A. Gurkan, P. Chen, F. Juillard, A. Tocchio, T. Chinnasamy, C. Beauchemin, S. Unluisler, S. Canikyan, A. Holman, S. Srivatsa, K. M. Kaye, U.
  Demirci Scientific Reports, 2016, 6: 39144 

• Emerging Point-of-Care Technologies for Sickle Cell Disease Screening and Monitoring 
  Alapan Y., A. Fraiwan, E. Kucukal, M. N. Hasan, R. Ung, M. Kim, I. Odame, J. A. Little, U. A. Gurkan
  Expert Review of Medical Devices, 2016, 13(12), 1073-1093

• Anisotropically Stiff 3D Micropillar Niche Induces Extraordinary Cell Alignment and Elongation 
  Alapan Y., M. Younesi, O. Akkus, U. A.
  Gurkan Advanced Healthcare Materials, 2016, 5: 1884-1892

• Enhancing the Angular Sensitivity of Plasmonic Sensors Using Hyperbolic Metamaterials 
  Sreekanth K. V., Y. Alapan, M. ElKabbash, A. M. Wen, E. Ilker, M. Hinczewski, U. A. Gurkan, N. F. Steinmetz, G.
  Strangi Advanced Optical Materials, 2016, 4: 1767-1772

• A multiband Perfect Absorber Based on Hyperbolic Metamaterials
  Sreekanth K. V., M. ElKabbash, Y. Alapan, A. R. Rashed, U. A. Gurkan, G.
  Strangi Scientific Reports, 2016, 6: 26272

• Extreme Sensitivity Biosensing Platform Based on Hyperbolic Metamaterials 
  Sreekanth K. V., Y. Alapan, M. ElKabbash, E. Ilker, M. Hinczewski, U. A. Gurkan, A. De Luca, G.
  Strangi Nature Materials, 2016, 15: 621-627

• SCD Biochip: A Functional Red Blood Cell Adhesion Assay for Monitoring Sickle Cell Disease 
  Alapan Y., C. Kim, A. Adhikari, K. E. Gray, E. Gurkan-Cavusoglu, J. A. Little, U. A.
  Gurkan Translational Research, 2016, 173: 74-91

• Dynamic Deformability of Sickle Red Blood Cells in Microphysiological Flow 
  Alapan Y., Y. Matsuyama, J. A. Little, U. A.
  Gurkan Technology, 2016, Vol. 4, No. 02, pp. 71-79

• Application of Hydrogels in Ocular Tissue Engineering 
  Kishore V., Y. Alapan, R. Iyer, R. Mclay, U. A. Gurkan Gels Handbook Fundamentals, Properties and Applications, Volume 2: Applications of Hydrogels in Regenerative Medicine,
  World Scientific Publishing, 2016

• Gels Handbook Fundamentals, Properties and Applications Volume 2: Applications of Hydrogels in Regenerative Medicine 
  Edited by: Mohammad Reza Abidian (University of Houston, USA), Umut Atakan Gurkan (Case Western Reserve University, USA), Faramarz Edalat (Emory University, USA)
  World Scientific Publishing, 2016

2015 

• Micro- and nanodevices integrated with biomolecular probes
  Alapan Y., K. Icoz, U. A. Gurkan
  Biotechnology Advances, 2015, 33(8), 1727-1743

• Three-Dimensional Printing Based Hybrid Manufacturing of Microfluidic Devices
  Alapan H., M. N. Hasan, R. Shen, U. A. Gurkan
  Journal of Nanotechnology in Engineering and Medicine, 2015, 6(2), 021007

• Paper and Flexible Substrates as Materials for Biosensing Platforms to Detect Multiple Biotargets
  Shafiee H., W. Asghar, F. Inci, M. Yuksekkaya, M. Jahangir, M. H. Zhang, N.G. Durmus, U. A. Gurkan, D. R. Kuritzkes, U. Demirci
  Scientific Reports, 2015, 5: 8719

• Functional Maintenance of Differentiated Embryoid Bodies in Microfluidic Systems: A Platform for Personalized Medicine
  Guven S., J. S. Lindsey, I. Poudel I, S. Chinthala, M. D. Nickerson, B. Gerami-Naini, U. A. Gurkan, R. M. Anchan, U. Demirci
  Stem Cells Translational Medicine, 2015, 4:1-8

2014

• Heterogeneous Red Blood Cell Adhesion and Deformability in Sickle Cell Disease
  Alapan Y., J. A. Little, U. A. Gurkan
  Scientific Reports, 2014, 4: 7173

• Micro and Nano-scale Technologies for Cell Mechanics
  Unal M., Y. Alapan, H. Jia, A. G. Varga, K. Angelino, M. Aslan, I. Sayin, C. Han, Y. Jiang, Z. Zhang, U. A. Gurkan
  Nanobiomedicine, 2014, 4: 7173

• An RF/Microwave Microfluidic Sensor Based on a 3D Capacitive Structure with a Floating Electrode for Miniaturized Dielectric Spectroscopy
  Suster, M. A., B. Blackburn, U. A. Gurkan, P. Mohseni
  IEEE Sensors, 2014, 1784-1787

• Bio-Inspired Cryo-Ink Preserves Red Blood Cell Phenotype and Function During Nanoliter Vitrification
  El Assal R., S. Guven, U. A. Gurkan, I. Gozen, H. Shafiee, S. Dalbeyler, N. Abdalla, G. Thomas, W. Fuld, B. M. W. Illigens, J. Estanislau, J. Khoory, R. Kaufman, C. Zylberberg, N. Lindeman, Q. Wen, I. Ghiran, U. Demirci
  Advanced Materials, 2014, 26 (33), 5815-5822

• Evaluation of Epithelial Chimerism After Bone Marrow Mesenchymal Stromal Cell Infusion in Intestinal Transplant Patients
  Kilinc S., U. A. Gurkan, S. Guven, G. Koyuncu, S. Tan, C. Karaca, O. Ozdogan, M. Dogan, C. Tugmen, E. E. Pala, U. Bayol, M. Baran, Y. Kurtulmus, I. Pirim, E. Kebapci, U. Demirci
  Transplantation proceedings, 2014, 46 (6), 2125-2132

• Making the Smallest Medical Devices
  Alapan Y., S. Ismail, U. A. Gurkan
  Mechanical Engineering Magazine, 2014, 136 (2), 36-38

• Engineering Anisotropic Biomimetic Fibrocartilage Microenvironment by Bioprinting Mesenchymal Stem Cells in Nanoliter Gel Droplets
  Gurkan U. A., R. El Assal, S. E. Yildiz, Y. Sung, A. J. Trachtenberg, W. P. Kuo, U. Demirci
  Molecular Pharmaceutics, 2014, PMID: 24495169

• Micro-a-fluidics ELISA for Rapid CD4 Cell Count at the Point-of-Care
  Wang S. Q., S. Tasoglu, P. Z. Chen, M. Chen, R. Akbas, S. Wach, C. I. Ozdemir, U. A. Gurkan, F. F. Giguel, D. R. Kuritzkes, U. Demirci
  Scientific Reports (Nature Publishing), 2014, 4:3796, PMID: 24448112

• Use of commercial off-the-shelf digital cameras for scientific data acquisition and scene-specific color calibration
  Akkaynak D., T. Treibitz, B. Xiao, U. A. Gurkan, J. J. Allen, U. Demirci, R. T. Hanlon
  Journal of the Optical Society of America A, 2014, 31(2), 312-321, PMID: 24562030

2013

• Simple precision creation of digitally specified, spatially heterogeneous, engineered tissue architectures
  Gurkan U. A.*, Y. Fan*, F. Xu, B. Erkmen, E. S. Urkac, G. Parlakgul, J. Bernstein, W. Xing, E. S. Boyden, U. Demirci
  Advanced Materials, 2013, 25(8), 1192-1198, PMID:23192949
  Highlighted in MIT News and Hurriyet

• In Vitro Three-Dimensional Cancer Culture Models
  Asghar W., H. Shafiee, P. Chen, S. Tasoglu, S. Guven, U. A. Gurkan, U. Demirci
  Cancer Targeted Drug Delivery, 2013, pp 635-665

• Nanoplasmonic Biosensing Platform for Multiple Pathogen Detection
  Inci F., O. Tokel, S. Wang, U. A. Gurkan, D. R. Kuritzkes, U. Demirci
  IEEE Transducers, 2013, 2431 - 2434, DOI: 10.1109/Transducers.2013.6627297

• Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules
  Rizvi I., U. A. Gurkan, S. Tasoglu, N. Alagic, J. P. Celli, L. B. Mensah, Z. Mai, U. Demirci, T. Hasan
  Proceedings of the National Academy of Sciences (PNAS), 2013, PMID:23645635

• Manipulating biological agents and cells in microscale volumes for applications in medicine
  Tasoglu S., U. A. Gurkan, S. Wang, U. Demirci
  Chemical Society Reviews, 2013, PMID:23575660

• Paramagnetic levitational assembly of hydrogels
  Tasoglu S., D. Kavaz, U. A. Gurkan, S. Guven, P. Chen, R. Zheng, U. Demirci
  Advanced Materials, 2013, 25(8), 1137-1143, PMID:23288557
  Cover Article in Advanced Materials

• Nanoplasmonic Quantitative Detection of Intact Viruses from Unprocessed Whole Blood
  Inci F.*, O. Tokel*, S. Wang*, U. A. Gurkan, S. Tasoglu, D. R. Kuritzkes, U. Demirci
  ACS Nano, 2013, PMID: 23688050

• Exhaustion of Racing Sperm in Nature Mimicking Microfluidic Channels During Sorting
  Tasoglu S., H. Safaee, X. Zhang, J. L. Kingsley, P. N. Catalano, U. A. Gurkan, A. Nureddin, E. Kayaalp, R. M. Anchan, R. L. Maas, E. Tüzel, U. Demirci
  Small, 2013, PMID: 23677651

2012

• Smart interface materials integrated with microfluidics for on-demand local capture and release of cells
  Gurkan U. A., S. Tasoglu, D. Akkaynak, O. Avci, S. Unluisler, S. Canikyan, N. MacCallum, U. Demirci
  Advanced Healthcare Materials,  2012, 1(5), 661-668

• Emerging technologies for assembly of microscale hydrogels
  Gurkan U. A.*, S. Tasoglu*, D. Kavaz, M. C. Demirel, U. Demirci
  Advanced Healthcare Materials, 2012, 1(2), 149-158

• Immune and inflammatory pathways are involved in inherent bone marrow ossification
  Gurkan U. A., V. Kishore, R. Golden, C. Riley, J. Adamec, O. Akkus
  Clinical Orthopedics and Related Research, 2012, 470, 2528–2540

• Efficient on-chip isolation of HIV subtypes
  Wang A. S.*, M. Esfahani*, U. A. Gurkan, F. Inci, U. Demirci
  Lab on A Chip, 2012, 12, 1508-1515

• Release of magnetic nanoparticles from cell-encapsulating biodegradable nanobiomaterials
  Xu F., F. Inci, O. Mullick, U. A. Gurkan, Y. Sung, D. Kavaz, B. Q. Li, E. B. Denkbas, U. Demirci
  ACS Nano, 2012, 6(8), 6640-6649

• Portable microfluidic chip for detection of Escherichia coli in produce and blood
  Wang A. S.*, Inci F.*, T. L. Chaunzwa, A. Ramanujam, A. Vasudevan, S. Subramanian, A. Ip, B. Sridharan, U. A. Gurkan, U. Demirci
  International Journal of Nanomedicine, 2012, 7, 2591-2600

• Prediction and control of the number of cells in microdroplets with stochastic modeling
  Ceyhan E.*, F. Xu*, U. A. Gurkan*, A. E. Emre, E. S. Turali, M. Wu, R. El Assal, A. Acikgenc, U. Demirci
  Lab on a Chip, 2012, 12, 4884-4893

2011

• Editorial: Scaffold-free cell-based approaches in biomedicine and biotechnology
  Gurkan U. A., F. Xu
  Biotechnology Journal 2011, 6 (12), 1426-1427

• A Scaffold-free multicellular three-dimensional in vitro model of osteogenesis
  Gurkan U. A., V. Kishore, K. W. Condon, T. M. Bellido, O. Akkus
  Calcified Tissue International, 2011, 88(5), 388-401

• Ossifying Bone Marrow Explant Culture as a Three-dimensional Mechanoresponsive In Vitro Model of Osteogenesis
  Gurkan U. A., A. Krueger, O. Akkus
  Tissue Engineering Journal Part A, 2011, 17(3-4), 417-428

• System and method for prevention of hypertrophic scars by actuable patch
  Akkus O., U. A. Gurkan, A. Aref, R. Meldrum
  International Patent, World Intellectual Property Organization, Issued: 29
  December 2011, WO 2011/163673 A2

• Transport of a soft cargo on a nanoscale ratchet
  Sekeroglu K.*, U. A. Gurkan*, U. Demirci, M. C. Demirel
  Applied Physics Letters, 2011, 99, 063703

• Controlled viable release of selectively captured label-free cells in microchannels
  Gurkan U. A., T. Anand, H. Tas, D. Elkan, A. Akay, H. O. Keles, U. Demirci
  Lab on a Chip, 2011, 11, 3979-3989
  Top 10 most accessed article in October 2011 in Lab on a Chip

• Miniaturized lensless imaging systems for cell and microorganism visualization in point-of-care testing
  Gurkan U. A.*, S. Moon*, H. Geckil, S. Wang, F. Xu, T.J. Lu, U. Demirci
  Biotechnology Journal, 2011. 6(2), 138-149

• Enumeration of CD4+ T-cells using a portable microchip count platform in Tanzanian HIV-infected patients
  Moon S., U. A. Gurkan, J. Blander, W. W. Fawzi, S. Aboud, F. Mugusi, D. Kuritzkes, U. Demirci
  PloS One, 2011, 6(7) e21409
  Highlighted in: Lab on A Chip, 2011, 11, 3211-3213

• Lensless imaging for simultaneous microfluidic sperm monitoring and tracking
  Zhang X.*, P. I. Khimji*, U. A. Gurkan, H. Safaee, P. Catalano, H. O. Keles, E. Kayaalp, U. Demirci
  Lab on A Chip, 2011, 11, 2535-2540
  Highlighted in Nature Photonics, 5, 512 (2011)

• Statistical modeling of single target cell encapsulation
  Moon S, E. Ceyhan, U. A. Gurkan, U. Demirci
  PloS One, 2011, 6(7): e21580

• Emerging Technologies in Medical Applications of Minimum Volume Vitrification
  Zhang X., P. N. Catalono, U. A. Gurkan, P. I. Khimji, U. Demirci
  Nanomedicine, 2011, 6(6), 1115-1129

• Nanoliter Droplet Vitrification for Oocyte Cryopreservation
  Zhang X., P. I. Khimji, L. Shao, H. Safaee, K. Desai, H. O. Keles, U. A. Gurkan, E. Kayaalp, A. Nureddin, R. M. Anchan, R. L. Maas, U. Demirci
  Nanomedicine, 2011, 7(4), 553-564

• Embryonic stem cell printing for controllable uniform sized embryoid body formation
  Xu F., B. Sridharan, S. Wang, U. A. Gurkan, B. Syverud, U. Demirci
  Biomicrofluidics, 2011, 5, 022207

• Living bacterial sacrificial porogens for porous hydrogel scaffolds
  Xu F., B. Sridharan, S. Wang, N. G. Durmus, A. S. Yavuz, U. A. Gurkan, U. Demirci
  PLoS One, 2011 6(4): e19344

• Microengineering Methods for Cell Based Microarrays and High Throughput Drug Screening Applications
  Xu F., J. Wu, S. Wang, N. G. Durmus, U. A. Gurkan, U. Demirci
  Biofabrication, 2011 Sep; 3(3): 034101

• Automated and Adaptable Quantification of Cellular Alignment from Microscopic Images for Tissue Engineering Applications
  Xu F., Beyazoglu T., E. Hefner, U. A. Gurkan, U. Demirci
  t/bml/media/201/edit

• Three-dimensional magnetic assembly of microscale hydrogels
  Xu F., C. M. Wu, V. Rengarajan, T. D. Finley, H. O. Keles, Y. Sung, B. Q. Li, U. A. Gurkan, U. Demirci
  Advanced Materials, 2011, 23(37), 4254–4260

• The assembly of cell-encapsulating microscale hydrogels using acoustic waves
  Xu F., T. D. Finley, M. Turkaydin, Y. Sung, U. A. Gurkan, R. Guldiken, U. Demirci
  Biomaterials, 2011, 32(31):7847-55

2010 

• Comparison of morphology, orientation, and migration of tendon derived fibroblasts and bone marrow stromal cells on electrochemically aligned collagen constructs
  Gurkan U. A., X. Cheng*, V. Kishore*, J. A. Uquillas, O. Akkus
  Journal of Biomedical Materials Research Part A, 2010, 94A(4), 1070-1079

• The sequential production profiles of growth factors and their relations to bone volume in ossifying bone marrow explants
  Gurkan U. A., J. Gargac, O. Akkus
  Tissue Engineering Journal Part A, 2010, 16(7), 2295-2306

• Engineering of bone marrow in vitro for investigating the role of growth factors and their mechanoresponsiveness in osteogenesis
  Gurkan U. A.
  PhD Dissertation, Purdue University, Indiana, 2010, 3413893

2009

• Osteogenic Effects of Preparations of rat pulmonary alveolar macrophages challenged with staphylococcus aureus
  Meldrum R. D., U. A. Gurkan, S. A. Kattaya, O. Akkus
  Indiana Orthopaedic Journal, 2009, Vol. 3, 28-29

2008 

• The mechanical environment of bone marrow
  Gurkan U. A., O. Akkus
  Annals of Biomedical Engineering, 2008, 36(12), 1978-1991

• An electrochemical fabrication process for the assembly of anisotropically oriented collagen bundles
  Cheng X., U. A. Gurkan, C. J. Dehen, M. P. Tate, H. W. Hillhouse, G. J. Simpson, O. Akkus
  Biomaterials, 2008, 29(22), 3278-3288

• State estimator design for multicomponent batch distillation columns
  Yildiz U., U. A. Gurkan, C. Ozgen, K. Leblebicioglu
  Chemical Engineering Research & Design, 2005. 83(A5), 433-444