Elaine Ann received her MS in Medical Physiology from Case Western Reserve University after graduating with a BS from the University of California – Los Angeles. Her research interests are centered on the development of epigenomic and transcriptomic profiles of various cardiometabolic and other noncommunicable diseases. Current and past work include circadian rhythm disruption, metabolic and behavioral phenotyping including mouse models for Alzheimer’s Disease, characterization of peripheral immune cell populations in lung inflammation, as well as investigation into chromatin dynamics and gene regulation employing advanced lab techniques in ATAC-Seq, ChIP-Seq, and qPCR. Environmental stressors such as air pollution are a main focus as it is indicated in noncommunicable diseases. Elaine Ann hopes to continue contributing to advancing our understanding of the phenotypes and mechanisms underlying pathogenesis of these prevalent diseases.
Publications
Palanivel R, Vinayachandran V, Biswal S, Deiuliis JA, Padmanabhan R, Park B, Gangwar RS, Durieux JC, Ebreo Cara EA, Das L, Bevan G, Fayad ZA, Tawakol A, Jain MK, Rao S, Rajagopalan S. Exposure to Air Pollution Disrupts Circadian Rhythm through Alterations in Chromatin Dynamics. (2020). iScience (2020) 23:101728.
Gangwar RS, Vinayachandran V, Palanivel R, Chan R, Park B, Diamond-Zaluski R, Cara EA, Cha A, Das L, Asase C, Maiseyeu A, Deiuliis J, Zhong J, Mitzner W, Biswal S, Rajagopalan S. Differential contribution of bone marrow-derived infiltrating monocytes and resident macrophages to persistent lung inflammation in chronic air pollution exposure. Sci Rep. (2020)1:14348.
Cara, E.A.E., Chu, S., Eshaghian-Wilner, M., Mlinar, E., Nojeh, A., Rofail, F., Safaee, M.M., Singh, S., Wu, D., Yip, C.W. (2009) Bio-Inspired and Nanoscale Integrated Computing, An Introduction to Nanocomputing (pp. 1-30) Hoboken, NJ, John Wiley & Sons, Inc.
Presentations
SOT 2023
“Air Pollution Induced Early Onset of Cognitive Decline in Mice: Implication of Blood Brain Barrier Dysfunction”, Society of Toxicology Third Author
“Single Cell RNA Sequencing Analysis in Atherosclerosis Reveals Unique Cell Types and Differential Profiles in Response to Chronic Exposure to Ambient Air Pollution”, Society of Toxicology, Fifth Author
APS 2023
“Endothelial mesenchymal transition with air pollution mediated atherosclerosis: insights from single cell RNA sequencing and trajectory inference analysis”, Inaugural American Physiology Summit, Second Author
“Single-cell Sequencing Reveals Smooth-Muscle Fibroblast Transition in Air Pollution Mediated Atherosclerosis”, Third Author
SOT 2020
The Toxicologist, Supplement to Toxicological Sciences, 174 (1), abstract #1153, 2020, Air Pollution Exposure as a Circadian Disruptor: Implications for Insulin Resistance and Type 2 Diabetes, First Author
The Toxicologist, Supplement to Toxicological Sciences, 174 (1), abstract #1152, 2020, Air Pollution (PM2.5) Triggers Insulin Resistance in Mice: Implication of Impaired Transcriptional Level of Circadian Gene and Glucose Metabolism in Brown Adipose Tissue, Third Author
The Toxicologist, Supplement to Toxicological Sciences, 174 (1), abstract #1139, 2020, Chronic PM2.5 Exposure-Mediated Recruitment of Bone Marrow-Derived Macrophages: Impact on Pulmonary Immune Homeostasis and Inflammation, Seventh Author