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  4. Xin Yu

Xin Yu, ScD

Professor
Department of Biomedical Engineering
Case School of Engineering
School of Medicine
Professor
Department of Physiology and Biophysics
School of Medicine
Professor
Department of Radiology
School of Medicine

Research Information

Research Interests

  • Magnetic resonance imaging and spectroscopy
  • In vivo metabolic imaging in diabetes and stroke
  • Magnetic resonance fingerprinting in pre-clinical studies

Our laboratory is devoted to the development of magnetic resonance imaging (MRI) and spectroscopic imaging (MRSI) methods for integrative understanding of several prevalent diseases such as diabetes, stroke, and heart diseases.  These diseases share a common underlying cause - metabolic dysfunction. We aim to develop state-of-the-art MRI and MRSI methods for noninvasive characterization of various aspects of tissue metabolism, from substrate delivery to oxygen utilization.  Some of these technologies hold the potential for early detection of metabolic dysfunction.  We also collaborate with investigators in basic science research to apply these technologies to laboratory animal models, including genetically engineered mouse models, for better understanding of the mechanisms leading to abnormal metabolism, and the response to therapeutic interventions.

For more information visit Xin Yu's lab website.

Awards and Honors

Research Award
2008
Case Western Reserve University School of Engineering
Clement Vaturi Fellowship in Biomedical Engineering
1994
Massachusetts Institute of Technology
Clement Vaturi Fellowship in Biomedical Engineering
1993
Massachusetts Institute of Technology
Wolkman Fellowship of W.G.C. Whiting School of Engineering
1990
The Johns Hopkins University
Wolkman Fellowship of W.G.C. Whiting School of Engineering
1989
The Johns Hopkins University
Fellow
American Institute for Medical and Biological Engineering (AIMBE)

Professional Memberships

American Association for the Advancement of Science
American Heart Association

Publications

  • Yu, X. (2022). Global Input Delay Tolerance of MIMO Nonlinear Systems Under Nonsmooth Feedback: A Homogeneous Perspective. IEEE. Trans. on Automat. Contr., 68 (7), 3992-4007.
  • Kim, K., Gu, Y., Wang, C., Clifford, B., Huang, S., Liang, Z., & Yu, X. (2020). Quantification of creatine kinase reaction rate in mouse hindlimb using phosphorus-31 magnetic resonance spectroscopic fingerprinting. NMR in Biomedicine.
  • Clifford, B., Gu, Y., Liu, Y., Kim, K., Huang, S., Li, Y., Lam, F., Liang, Z., & Yu, X. (2020). High-Resolution Dynamic 31 P-MR Spectroscopic Imaging for Mapping Mitochondrial Function. IEEE Transactions on Biomedical Engineering, 67 (10), 2745-2753.
  • Tao, J., Wang, Z., Yu, X., Tang, Y., Yu, J., Wang, S., Haas, M., Glassock, R., & Zhao, M. (2020). A Validation of the 2018 Revision of International Society of Nephrology/Renal Pathology Society Classification for Lupus Nephritis: A Cohort Study from China.. American journal of nephrology.
  • Alapan, Y., Yu, X., Du , X., Li , Q., Li , X., Qin, T., Wang, X., Jiang, B., Li , J., Li , W., Zhang, G., Xu, Z., & Zhang, L. (2020). Epidemiological and clinical characteristics of 26 asymptomatic SARS-CoV-2 carriers.. The Journal of infectious diseases.
  • Bai, M., Niu, W., Zhou, Y., Gong, Y., Lu, Y., Yu, X., Weinrich, Z., Wuttisarnwattana, P., Song, H., Yueh, W., Gunalan, K., Cai, P., & Chu, X. (2020). Association of common variation in <i>ADD3</i> and <i>GPC1</i> with biliary atresia susceptibility.. Aging, 12
  • Meng, J., Huang, T., Mei, X., Yu, X., Pan, Z., Tomaszewski, J., Schepelmann, A., Chen, J., Guo, X., & Yang, Z. (2020). Adjuvant breast inversely planned intensity-modulated radiotherapy with simultaneous integrated boost for early stage breast cancer : Results from a phase II trial.. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al].
  • Cheng, C., Prieto-Dominguez, N., Yang, S., Connelly, Z., StPierre, S., Rushing, B., Watkins, A., Joshi-Imre, A., Lakey, M., Baiamonte, L., Fazili, T., Lurie, A., Corey, E., Bakhshiani, M., Yeh, Y., & Yu, X. (2020). The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancer.. Prostate cancer and prostatic diseases.
  • Zhao, Y., Cheng, C., Yu, X., & Xu, Y. (2020). Chinese Public Attention to COVID-19 Epidemic: Based on Social Media.. Journal of medical Internet research.
  • Perry, J., Tao, F., Roy, A., Pangilinan, K., Schepelmann, A., Cheng, C., Lu, X., Nemechek, J., Ruan, L., Yu, X., Dukes, D., Moran, A., Pace, J., Schroeder, K., Zhao, M., Venkatraman, K., Qian, P., Li , Z., Hembree, M., Paulson, A., Kasheff, Z., Xu, D., Mitrani, J., Deshmukh, P., Nguyen, B., Kasi, R., Ryan, C., Broward, M., Ludington-Hoe, S., Guest, E., August, K., Gamis, A., Godwin, A., Sittampalam, G., Weir, S., & Li , L. (2020). Overcoming Wnt-β-catenin dependent anticancer therapy resistance in leukaemia stem cells.. Nature cell biology.
  • Jiang, C., Shuai, Z., Mingji, Y., Kandhari, A., Zhizhong, L., Weiqing, H., & Yu, X. (2020). Evaluation of Three-dimensional Printing Assisted Laparoscopic Cryoablation of Small Renal Tumors: A Preliminary Report.. Urology journal.
  • Yang, J., Karathanasis, E., Chen, Q., Zhu, Z., Zhao, Y., Yu, X., Zhu, H., Cao, J., & Li , X. (2020). Reversible splenial lesion syndrome (RESLES) due to acute intermittent porphyria with a novel mutation in the hydroxymethylbilane synthase gene.. Orphanet journal of rare diseases, 15 (1), 98.
  • Sunday, M., Xu, J., Zhu, H., Yu, X., & Yang, J. (2020). Clinical presentation and management of acquired thrombotic thrombocytopenic purpura: a case series of 55 patients.. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
  • Liu, L., Ren, X., Li , H., Yu, X., Zhao, B., Liu, X., & Ning, Z. (2020). Development of the reverse genetics system for emerging atypical porcine pestivirus using in vitro and intracellular transcription systems.. Virus research.
  • Yu, X., Mahfud, R., Dong, D., Zhou, F., & Dunning, J. (2020). An Improved Lagrangian-Inverse Method for Evaluating the Dynamic Constitutive Parameters of Concrete.. Materials (Basel, Switzerland), 13 (8).
  • Qian, C., Zhou, Z., Sun, X., Wu, M., Sun, S., & Yu, X. (2020). Effects of expressive writing intervention for women's PTSD, depression, anxiety and stress related to pregnancy: A meta-analysis of randomized controlled trials.. Psychiatry research, 288 , 112933.
  • Li , M., Li , Y., Yu, X., Guo, J., Xiang, L., Liu, X., Zhao, H., Xu, M., Feng, J., Yu, N., Cai, Q., & Morlock, C. (2020). Improved bio-electricity production in bio-electrochemical reactor for wastewater treatment using biomass carbon derived from sludge supported carbon felt anode.. The Science of the total environment, 726 , 138573.
  • Wang, J., Li , X., Liu, Y., Peng, C., Zhu, H., Tuxhorn, I., Yu, X., & Li , Z. (2020). CircHIPK3 Promotes Pyroptosis in Acinar Cells Through Regulation of the miR-193a-5p/GSDMD Axis.. Frontiers in medicine, 7 , 88.
  • Alambyan, V., Pace, J., Sukpornchairak, P., Yu, X., Alnimir, H., Tatton, R., Chitturu, G., Yarlagadda, A., & Ramos-Estebanez, C. (2020). Imaging Guidance for Therapeutic Delivery: The Dawn of Neuroenergetics. Neurotherapeutics, 17 (2), 522-538.
  • Zhou, Y., Zhou, Z., Ji, S., Yang, W., Li , H., & Yu, X. (2020). Tetramethylpyrazine reduces prostate cancer malignancy through inactivation of the DPP10‑AS1/CBP/FOXM1 signaling pathway.. International journal of oncology.
  • Mulvihill, M., Luo, R., Estill, J., Liu, Y., Prentiss, M., Wang, J., Wang, Q., Zhao, S., Wang, X., Yang, S., Feng, J., Li , W., Liu, X., Zhang, G., Wang, Y., Zhou, Q., Meng, W., Qi, X., Xun, Y., Yu, X., Chen, Q., & On Behalf Of The Covid-Evidence And Recommendations Working Group, Q. (2020). Coronavirus disease (COVID-19): a scoping review.. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 25 (15).
  • Geng, S., Pangilinan, K., Zhou, W., Malcuit, C., Wu, J., Li , Z., Chung, S., & Yu, X. (2020). Bioactive phospho-therapy with black phosphorus for <i>in vivo</i> tumor suppression.. Theranostics, 10 (11), 4720-4736.
  • Cui, Y., Yu, X., Zhang, X., Tang, Y., Tang, X., Yang, S., Ping, X., Wu, J., Yin, Q., Zhou, J., Xu, X., & Shentu, X. (2020). Association of IGF1R polymorphisms (rs1546713) with susceptibility to age-related cataract in a Han Chinese population.. International journal of ophthalmology, 13 (3), 374-381.
  • Liu, C., Deng, S., Fujino, Y., Gong, Y., Cheng, C., Fan, Z., Qian, Z., Huang, J., Ni, Q., Luo, C., & Yu, X. (2020). Lewis antigen‑negative pancreatic cancer: An aggressive subgroup.. International journal of oncology.
  • Zhu, C., Masarapu, H., Gu, Y., Zhang, Y., Yu, X., & Steinmetz, N. (2019). Physalis Mottle Virus-like Nanoparticles for Targeted Cancer Imaging. ACS Applied Materials & Interfaces, 11 (20), 18213-18223.
  • Wang, C., Coppo, S., Mehta, B., Seiberlich, N. E., Yu, X. E., & Griswold, M. E. (2019). Magnetic resonance fingerprinting with quadratic RF phase for measurement of T<sub>2</sub> <sup>*</sup> simultaneously with δ<sub>f</sub> , T<sub>1</sub> , and T<sub>2</sub>.. Magnetic resonance in medicine, 81 (3), 1849-1862.
  • Gusley, R., Wang, C., Anderson, C., Liu, Y., Hudson, R., Johansen, M., Mahanta, N., Jiang, Y., Ramos-Estebanez, C., Brady-Kalnay, S., Griswold, M., Flask, C., & Yu, X. (2018). Fast magnetic resonance fingerprinting for dynamic contrast-enhanced studies in mice.. Magnetic resonance in medicine, 80 (6), 2681-2690.
  • Wang, C., Coppo, S., Mehta, B., Seiberlich, N. E., Yu, X. E., & Griswold, M. E. (2018). Magnetic resonance fingerprinting with quadratic RF phase for measurement of T 2 * simultaneously with df, T 1 , and T 2. Magnetic Resonance in Medicine.
  • Gu, Y., Wang, C., Anderson, C., Liu, Y., Zhu, C., Johansen, M., Ma, D., Jiang, Y., Ramos-Estebanez, C., Brady-Kalnay, S., Griswold, M., Flask, C., & Yu, X. (2018). Fast magnetic resonance fingerprinting for dynamic contrast-enhanced studies in mice: Gu et al.. Magnetic Resonance in Medicine, 80 (6), 2681-2690.
  • Anderson, C., Wang, C., Gu, Y., Darrah, R., Griswold, M., Yu, X., & Flask, C. (2018). Regularly incremented phase encoding - MR fingerprinting (RIPE-MRF) for enhanced motion artifact suppression in preclinical cartesian MR fingerprinting: RIPE-MRF for Enhanced Motion Artifact Suppression. Magnetic Resonance in Medicine, 79 (4), 2176-2182.
  • Liu, Y., Gusley, R., & Yu, X. (2017). Assessing tissue metabolism by phosphorous-31 magnetic resonance spectroscopy and imaging: a methodology review.. Quantitative imaging in medicine and surgery, 7 (6), 707-726.
  • Wang, C., Liu, Y., Huang, S., Griswold, M., Seiberlich, N. E., & Yu, X. E. (2017). <sup>31</sup> P magnetic resonance fingerprinting for rapid quantification of creatine kinase reaction rate in vivo.. NMR in biomedicine, 30 (12).
  • Hudson, R., Zhang, Y., Shukla, S., Gusley, R., Yu, X., & Steinmetz, N. (2017). Dysprosium-Modified Tobacco Mosaic Virus Nanoparticles for Ultra-High-Field Magnetic Resonance and Near-Infrared Fluorescence Imaging of Prostate Cancer.. ACS nano, 11 (9), 9249-9258.
  • Zhang, Z., Li , Y., Roelle, S., Zhou, Z., Liu, Y., Sabatelle, R., DeSanto, A., Yu, X., Zhu, H., Magi-Galluzzi, C., & Lu, Z. (2017). Targeted Contrast Agent Specific to an Oncoprotein in Tumor Microenvironment with the Potential for Detection and Risk Stratification of Prostate Cancer with MRI.. Bioconjugate chemistry, 28 (4), 1031-1040.
  • Liu, Y., Zhang, Y., Wu, C., Wang, C., Tomko, N., Linetsky, M., Salomon, R., Ramos-Estebanez, C., Wang, Y., & Yu, X. (2017). High-resolution dynamic oxygen-17 MR imaging of mouse brain with golden-ratio-based radial sampling and k-space-weighted image reconstruction.. Magnetic resonance in medicine.
  • Zhang, Z., Li , Y., Roelle, S., Zhou, Z., Liu, Y., Sabatelle, R., DeSanto, A., Yu, X., Zhu, H., Magi-Galluzzi, C., & Lu, Z. (2017). Targeted Contrast Agent Specific to an Oncoprotein in Tumor Microenvironment with the Potential for Detection and Risk Stratification of Prostate Cancer with MRI.. Bioconjugate chemistry.
  • Donnola, S., Dasenbrook, E., Weaver, D., Berglund, L., Gupta, K., Prabhakaran, A., Yu, X., Chmiel, J., McBennett, K., Konstan, M., Drumm, M., & Flask, C. (2017). Preliminary comparison of normalized T1 and non-contrast perfusion MRI assessments of regional lung disease in cystic fibrosis patients.. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 16 (2), 283-290.
  • Maier, C., Schadock, I., Faulhaber, P., Wysocki, J., Nguyen, M., Kanwar, Y., Flask, C., Yu, X., Hoit, B., Adams, G., Schmaier, A., Bader, M., & Batlle, D. (2017). Prolylcarboxypeptidase deficiency is associated with increased blood pressure, glomerular lesions, and cardiac dysfunction independent of altered circulating and cardiac angiotensin II.. Journal of molecular medicine (Berlin, Germany).
  • Wu, C., Eck, B., Zhang, S., Zhu, J., Tiwari, A., Zhang, Y., Zhu, Y., Zhang, J., Wang, B., Wang, X., WAng, X., You, J., Wang, J., Guan, Y., Liu, X., Yu, X., Trapp, B., Miller, R., Silver, J., Wilson, D. L., & Wang, Y. L. (2017). Discovery of 1,2,3-Triazole Derivatives for Multimodality PET/CT/Cryoimaging of Myelination in the Central Nervous System. Journal of Medicinal Chemistry, 60 (3), 987--999.
  • Wallat, J., Czapar, A., Wang, C., Wen, A., Wek, K., Yu, X., Steinmetz, N., & Pokorski, J. K. (2017). Optical and Magnetic Resonance Imaging Using Fluorous Colloidal Nanoparticles.. Biomacromolecules, 18 (1), 103-112.
  • Zhu, C., Zhang, Y., Shukla, S., Gu, Y., Yu, X., & Steinmetz, N. (2017). Dysprosium-Modified Tobacco Mosaic Virus Nanoparticles for Ultra-High-Field Magnetic Resonance and Near-Infrared Fluorescence Imaging of Prostate Cancer. ACS Nano, 11 (9), 9249-9258.
  • Wang, C., Liu, Y., Huang, S., Griswold, M., Seiberlich, N. E., & Yu, X. E. (2017). 31 P magnetic resonance fingerprinting for rapid quantification of creatine kinase reaction rate in vivo. NMR in Biomedicine.
  • Ma, C., Clifford, B., Liu, Y., Gu, Y., Lam, F., Yu, X., & Liang, Z. (2017). High-resolution dynamic 31 P-MRSI using a low-rank tensor model: 31 P-Spice. Magnetic Resonance in Medicine.
  • Anderson, C., Donnola, S., Jiang, Y., Batesole, J., Darrah, R., Drumm, M., Brady-Kalnay, S., Steinmetz, N., Yu, X., Griswold, M., & Flask, C. (2017). Dual Contrast - Magnetic Resonance Fingerprinting (DC-MRF): A Platform for Simultaneous Quantification of Multiple MRI Contrast Agents. Scientific Reports, 7 (1).
  • Chen, Q., Li , W., Jiang, K., Wang, C., & Yu, X. (2016). Rapid T2 mapping of mouse heart using the carr-purcell-meiboom-gill sequence and compressed sensing reconstruction.. Journal of magnetic resonance imaging : JMRI, 44 (2), 375-82.
  • Liu, Y., Mei, X., Li , J., Lai, N., & Yu, X. (2016). Mitochondrial function assessed by 31P MRS and BOLD MRI in non-obese type 2 diabetic rats.. Physiological reports, 4 (15).
  • Jiang, K., Jiao, S., Vitko, M., Darrah, R., Flask, C., Hodges, C., & Yu, X. (2016). The impact of Cystic Fibrosis Transmembrane Regulator Disruption on cardiac function and stress response.. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 15 (1), 34-42.
  • Jiang, K., Li , W., Jiao, S., Castel, L., Van Wagoner, D., & Yu, X. (2015). Rapid multislice T1 mapping of mouse myocardium: Application to quantification of manganese uptake in α-Dystrobrevin knockout mice.. Magnetic resonance in medicine, 74 (5), 1370-9.
  • Wen, A., Wang, Y., Jiang, K., Hsu, G., Gao, H., Lee, K., Yang, S., Yu, X., Simon, D., & Steinmetz, N. (2015). Shaping bio-inspired nanotechnologies to target thrombosis for dual optical-magnetic resonance imaging.. Journal of materials chemistry. B, Materials for biology and medicine, 3 (29), 6037-6045.
  • Schur, R., Sheng, L., Sahu, B., Yu, S., Gao, S., Yu, X., Maeda, A., Palczewski, K., & Lu, Z. (2015). Manganese-Enhanced MRI for Preclinical Evaluation of Retinal Degeneration Treatments.. Investigative ophthalmology & visual science, 56 (8), 4936-42.
  • Schur, R., Sheng, L., Sahu, B., Yu, S., Gao, S., Yu, X., Maeda, A., Palczewski, K., & Lu, Z. (2015). Manganese-Enhanced MRI for Preclinical Evaluation of Retinal Degeneration Treatments.. Investigative ophthalmology & visual science, 56 (8), 4936-42.
  • Wen, A., Wang, Y., Jiang, K., Hsu, G., Gao, H., Lee, K., Yang, A., Yu, X., Simon, D., & Steinmetz, N. (2015). Shaping bio-inspired nanotechnologies to target thrombosis for dual optical-magnetic resonance imaging. JOURNAL OF MATERIALS CHEMISTRY B, 3 (29), 6037-6045.
  • Chen, Q., Denoyer, L., Zhong, M., Li , X., Ryan, C., Chandler, M., Calvin, S., Xiao, F., Negia, M., Low, W., Zhang, J., & Yu, X. (2015). The Structural Basis of Functional Improvement in Response to Human Umbilical Cord Blood Stem Cell Transplantation in Hearts With Postinfarct LV Remodeling.. Cell transplantation, 24 (6), 971-83.
  • Chen, Q., Denoyer, L., Zhong, M., Liu, X., Ryan, C., Chandler, M., Calvin, S., Xiao, F., Negia, M., Low, W., Zhang, J., & Yu, X. (2015). The Structural Basis of Functional Improvement in Response to Human Umbilical Cord Blood Stem Cell Transplantation in Hearts With Postinfarct LV Remodeling. CELL TRANSPLANTATION, 24 (6), 971-983.
  • Goodnough, C., Gao, Y., Li , X., Qutaish, M., Goodnough, L., Molter, J., Wilson, D. L., Flask, C. L., & Yu, X. L. (2014). Lack of dystrophin results in abnormal cerebral diffusion and perfusion in vivo.. NeuroImage, 102 Pt 2 , 809-16.
  • Jiang, K., & Yu, X. (2014). Quantification of regional myocardial wall motion by cardiovascular magnetic resonance.. Quantitative imaging in medicine and surgery, 4 (5), 345-57.
  • Gao, Y., Goodnough, C., Erokwu, B., Farr, G., Darrah, R., Berglund, L., Dell, K., Yu, X., & Flask, C. (2014). Arterial spin labeling-fast imaging with steady-state free precession (ASL-FISP): a rapid and quantitative perfusion technique for high-field MRI.. NMR in biomedicine, 27 (8), 996-1004.
  • Bruckman, M., Jiang, K., Simpson, E., Randolph, L., Luyt, L., Yu, X., & Steinmetz, N. (2014). Dual-modal magnetic resonance and fluorescence imaging of atherosclerotic plaques in vivo using VCAM-1 targeted tobacco mosaic virus.. Nano letters, 14 (3), 1551-8.
  • Bruckman, M., Jiang, K., Simpson, E., Randolph, L., Luyt, L., Yu, X., & Steinmetz, N. (2014). Dual-modal magnetic resonance and fluorescence imaging of atherosclerotic plaques in vivo using VCAM-1 targeted tobacco mosaic virus.. Nano letters, 14 (3), 1551-8.
  • Chen, Q., Denoyer, L., Zhong, M., Li , X., Ryan, C., Chandler, M., Calvin, S., Xiao, F., Negia, M., Low, W., Zhang, J., & Yu, X. (2013). The Structural Basis of Functional Improvement in Response to Human Umbilical Cord Blood Stem Cell Transplantation.. Cell transplantation.
  • Bruckman, M., Yu, X., & Steinmetz, N. (2013). Engineering Gd-loaded nanoparticles to enhance MRI sensitivity via T(1) shortening.. Nanotechnology, 24 (46), 462001.
  • Bruckman, M., Yu, X., & Steinmetz, N. (2013). Engineering Gd-loaded nanoparticles to enhance MRI sensitivity via T(1) shortening.. Nanotechnology, 24 (46), 462001.
  • Wu, Y., Balu, N., Li , W., Chen, Q., Joshi-Imre, A., Kummitha, C., Yu, X., Yuan, C., & Lu, Z. (2013). Molecular MRI of atherosclerotic plaque progression in an ApoE(-/-) mouse model with a CLT1 peptide targeted macrocyclic Gd(III) chelate.. American journal of nuclear medicine and molecular imaging, 3 (5), 446-55.
  • Montano, M., Desjardins, C., Doughman, Y., Hsieh, Y., Hughes, B., Bensinger, H., Wang, C., Stelzer, J., Dick, T., Hoit, B., Chandler, M., Yu, X., & Watanabe, M. (2013). Inducible re-expression of HEXIM1 causes physiological cardiac hypertrophy in the adult mouse.. Cardiovascular research, 99 (1), 74-82.
  • Montano, M., Desjardins, C., Doughman, Y., Hsieh, Y., Hughes, B., Bensinger, H., Wang, C., Stelzer, J., Dick, T., Hoit, B., Chandler, M., Yu, X., & Watanabe, M. (2013). Inducible re-expression of HEXIM1 causes physiological cardiac hypertrophy in the adult mouse.. Cardiovascular research, 99 (1), 74-82.
  • Bruckman, M., Hernandez, C., Jiang, K., Flask, C., Yu, X., & Steinmetz, N. (2013). Tobacco mosaic virus rods and spheres as supramolecular high-relaxivity MRI contrast agents.. Journal of materials chemistry. B, Materials for biology and medicine, 1 (10), 1482-1490.
  • Bruckman, M., Hernandez, C., Jiang, K., Flask, C., Yu, X., & Steinmetz, N. (2013). Tobacco mosaic virus rods and spheres as supramolecular high-relaxivity MRI contrast agents.. Journal of materials chemistry. B, Materials for biology and medicine, 1 (10), 1482-1490.
  • Azam, S., Desjardins, C., Schluchter, M., Liner, A., Stelzer, J., Yu, X., & Hoit, B. (2012). Comparison of velocity vector imaging echocardiography with magnetic resonance imaging in mouse models of cardiomyopathy.. Circulation. Cardiovascular imaging, 5 (6), 776-81.
  • Chen, Q., Payne, K., Perara, V., Huang, S., Baba, A., Matsuda, T., & Yu, X. (2012). Inhibition of the sodium-calcium exchanger via SEA0400 altered manganese-induced T1 changes in isolated perfused rat hearts.. NMR in biomedicine, 25 (11), 1280-5.
  • Azam, S., Desjardins, C., Schluchter, M., Liner, A., Stelzer, J., Yu, X., & Hoit, B. (2012). Comparison of velocity vector imaging echocardiography with magnetic resonance imaging in mouse models of cardiomyopathy.. Circulation. Cardiovascular imaging, 5 (6), 776-81.
  • Chen, Q., Payne, K., Perara, V., Huang, S., Baba, A., Matsuda, T., & Yu, X. (2012). Inhibition of the sodium-calcium exchanger via SEA0400 altered manganese-induced T1 changes in isolated perfused rat hearts.. NMR in biomedicine, 25 (11), 1280-5.
  • Li , W., Griswold, M., & Yu, X. (2012). Fast cardiac T1 mapping in mice using a model-based compressed sensing method.. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 68 (4), 1127-34.
  • Li , W., Griswold, M., & Yu, X. (2012). Fast cardiac T1 mapping in mice using a model-based compressed sensing method.. Magnetic resonance in medicine, 68 (4), 1127-34.
  • Berthiaume, J., Young, M., Cheng, X., McElfresh, T., Yu, X., & Chandler, M. (2012). Normalizing the metabolic phenotype after myocardial infarction: impact of subchronic high fat feeding.. Journal of molecular and cellular cardiology, 53 (1), 125-33.
  • Berthiaume, J., Young, M., Cheng, X., McElfresh, T., Yu, X., & Chandler, M. (2012). Normalizing the metabolic phenotype after myocardial infarction: impact of subchronic high fat feeding.. Journal of molecular and cellular cardiology, 53 (1), 125-33.
  • Plusquellic, J., Matthews, B., Mateescu, G., Flask, C., & Yu, X. (2012). Assessing mitochondrial respiration in isolated hearts using (17)O MRS.. NMR in biomedicine, 25 (6), 883-9.
  • Plusquellic, J., Matthews, B., Mateescu, G., Flask, C., & Yu, X. (2012). Assessing mitochondrial respiration in isolated hearts using (17)O MRS.. NMR in biomedicine, 25 (6), 883-9.
  • Desjardins, C., Chen, Q., Coulton, A., Hoit, B., Yu, X., & Stelzer, J. (2012). Cardiac myosin binding protein C insufficiency leads to early onset of mechanical dysfunction.. Circulation. Cardiovascular imaging, 5 (1), 127-36.
  • Desjardins, C., Chen, Q., Coulton, A., Hoit, B., Yu, X., & Stelzer, J. (2012). Cardiac myosin binding protein C insufficiency leads to early onset of mechanical dysfunction.. Circulation. Cardiovascular imaging, 5 (1), 127-36.
  • Cheng, Y., Li , W., McElfresh, T., Cheng, X., Berthiaume, J., Castel, L., Yu, X., Van Wagoner, D., & Chandler, M. (2011). Changes in myofilament proteins, but not Ca²⁺ regulation, are associated with a high-fat diet-induced improvement in contractile function in heart failure.. American journal of physiology. Heart and circulatory physiology, 301 (4), H1438-46.
  • Cheng, Y., Li , W., McElfresh, T., Cheng, X., Berthiaume, J., Castel, L., Yu, X., Van Wagoner, D., & Chandler, M. (2011). Changes in myofilament proteins, but not Ca²⁺ regulation, are associated with a high-fat diet-induced improvement in contractile function in heart failure.. American journal of physiology. Heart and circulatory physiology, 301 (4), H1438-46.
  • Li , W., Bian, F., Chaudhuri, P., Mao, X., Brunengraber, H., & Yu, X. (2011). Delineation of substrate selection and anaplerosis in tricarboxylic acid cycle of the heart by 13C NMR spectroscopy and mass spectrometry.. NMR in biomedicine, 24 (2), 176-87.
  • Li , W., Bian, F., Chaudhuri, P., Mao, X., Brunengraber, H., & Yu, X. (2011). Delineation of substrate selection and anaplerosis in tricarboxylic acid cycle of the heart by 13C NMR spectroscopy and mass spectrometry.. NMR in biomedicine, 24 (2), 176-87.
  • Plusquellic, J., Banerjee, S., Saidel, G. M., & Yu, X. M. (2011). Regulation of cytosolic and mitochondrial oxidation via malate-aspartate shuttle: an observation using dynamic ¹³C NMR spectroscopy.. Advances in experimental medicine and biology, 701 , 185-92.
  • Plusquellic, J., Banerjee, S., Saidel, G. M., & Yu, X. M. (2011). Regulation of cytosolic and mitochondrial oxidation via malate-aspartate shuttle: an observation using dynamic ¹³C NMR spectroscopy.. Advances in experimental medicine and biology, 701 , 185-92.
  • Li , W., Griswold, M., & Yu, X. (2010). Rapid T1 mapping of mouse myocardium with saturation recovery Look-Locker method.. Magnetic resonance in medicine, 64 (5), 1296-303.
  • Zhong, M., & Yu, X. (2010). Strain and torsion quantification in mouse hearts under dobutamine stimulation using 2D multiphase MR DENSE.. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 64 (5), 1315-22.
  • Chen, Q., Somji, A., Yu, X., & Stelzer, J. (2010). Altered in vivo left ventricular torsion and principal strains in hypothyroid rats.. American journal of physiology. Heart and circulatory physiology, 299 (5), H1577-87.
  • Li , W., Griswold, M., & Yu, X. (2010). Rapid T1 mapping of mouse myocardium with saturation recovery Look-Locker method.. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 64 (5), 1296-303.
  • Chen, Q., Somji, A., Yu, X., & Stelzer, J. (2010). Altered in vivo left ventricular torsion and principal strains in hypothyroid rats.. American journal of physiology. Heart and circulatory physiology, 299 (5), H1577-87.
  • Zhong, M., & Yu, X. (2010). Strain and torsion quantification in mouse hearts under dobutamine stimulation using 2D multiphase MR DENSE.. Magnetic resonance in medicine, 64 (5), 1315-22.
  • Li , W., & Yu, X. (2010). Quantification of myocardial strain at early systole in mouse heart: restoration of undeformed tagging grid with single-point HARP.. Journal of magnetic resonance imaging : JMRI, 32 (3), 608-14.
  • Li , W., & Yu, X. (2010). Quantification of myocardial strain at early systole in mouse heart: restoration of undeformed tagging grid with single-point HARP.. Journal of magnetic resonance imaging : JMRI, 32 (3), 608-14.
  • Li , W., Liu, W., Zhong, M., & Yu, X. (2009). Early manifestation of alteration in cardiac function in dystrophin deficient mdx mouse using 3D CMR tagging.. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 11 , 40.
  • Li , W., Liu, W., Zhong, M., & Yu, X. (2009). Early manifestation of alteration in cardiac function in dystrophin deficient mdx mouse using 3D CMR tagging.. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 11 , 40.
  • Li , W., Plusquellic, J., Banerjee, S., Zhong, M., Yellin, D., Molter, J., & Yu, X. (2009). Ex vivo diffusion tensor MRI reflects microscopic structural remodeling associated with aging and disease progression in normal and cardiomyopathic Syrian hamsters.. NMR in biomedicine, 22 (8), 819-25.
  • Li , W., Plusquellic, J., Banerjee, S., Zhong, M., Yellin, D., Molter, J., & Yu, X. (2009). Ex vivo diffusion tensor MRI reflects microscopic structural remodeling associated with aging and disease progression in normal and cardiomyopathic Syrian hamsters.. NMR in biomedicine, 22 (8), 819-25.
  • Zhong, M., Liu, W., & Yu, X. (2009). Transmural myocardial strain in mouse: quantification of high-resolution MR tagging using harmonic phase (HARP) analysis.. Magnetic resonance in medicine, 61 (6), 1368-73.
  • Zhong, M., Liu, W., & Yu, X. (2009). Transmural myocardial strain in mouse: quantification of high-resolution MR tagging using harmonic phase (HARP) analysis.. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 61 (6), 1368-73.
  • Plusquellic, J., Zhou, L., Stanley, W., Cabrera, M., Saidel, G. M., & Yu, X. M. (2008). Role of the malate-aspartate shuttle on the metabolic response to myocardial ischemia.. Journal of theoretical biology, 254 (2), 466-75.
  • Plusquellic, J., Zhou, L., Stanley, W., Cabrera, M., Saidel, G. M., & Yu, X. M. (2008). Role of the malate-aspartate shuttle on the metabolic response to myocardial ischemia.. Journal of theoretical biology, 254 (2), 466-75.
  • Zhong, M., Liu, W., & Yu, X. (2008). Characterization of three-dimensional myocardial deformation in the mouse heart: an MR tagging study.. Journal of magnetic resonance imaging : JMRI, 27 (6), 1263-70.
  • Zhong, M., Liu, W., & Yu, X. (2008). Characterization of three-dimensional myocardial deformation in the mouse heart: an MR tagging study.. Journal of magnetic resonance imaging : JMRI, 27 (6), 1263-70.
  • Jeyaraj, D., Wilson, D., Zhong, M., Flask, C., Saffitz, J., Deschênes, I., Yu, X., & Rosenbaum, D. (2007). Mechanoelectrical feedback as novel mechanism of cardiac electrical remodeling.. Circulation, 115 (25), 3145-55.
  • Jeyaraj, D., Wilson, D., Zhong, M., Flask, C., Saffitz, J., Deschênes, I., Yu, X., & Rosenbaum, D. (2007). Mechanoelectrical feedback as novel mechanism of cardiac electrical remodeling.. Circulation, 115 (25), 3145-55.
  • Liu, W., Ashford, M., Chen, J., Watkins, M., Williams, S., Wickline, S., & Yu, X. (2006). MR tagging demonstrates quantitative differences in regional ventricular wall motion in mice, rats, and men.. American journal of physiology. Heart and circulatory physiology, 291 (5), H2515-21.
  • Liu, W., Ashford, M., Chen, J., Watkins, M., Williams, S., Wickline, S., & Yu, X. (2006). MR tagging demonstrates quantitative differences in regional ventricular wall motion in mice, rats, and men.. American journal of physiology. Heart and circulatory physiology, 291 (5), H2515-21.
  • Zhou, L., Yu, X., Cabrera, M., & Stanley, W. (2006). Role of cellular compartmentation in the metabolic response to stress: mechanistic insights from computational models.. Annals of the New York Academy of Sciences, 1080 , 120-39.
  • Zhou, L., Yu, X., Cabrera, M., & Stanley, W. (2006). Role of cellular compartmentation in the metabolic response to stress: mechanistic insights from computational models.. Annals of the New York Academy of Sciences, 1080 , 120-39.
  • Chung, J., Abraszewski, P., Yu, X., Liu, W., Krainik, A., Ashford, M., Caruthers, S., McGill, J., & Wickline, S. (2006). Paradoxical increase in ventricular torsion and systolic torsion rate in type I diabetic patients under tight glycemic control.. Journal of the American College of Cardiology, 47 (2), 384-90.
  • Zhou, L., Stanley, W., Saidel, G. M., Yu, X. M., & Cabrera, M. M. (2005). Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD+: insights from in silico studies.. The Journal of physiology, 569 (Pt 3), 925-37.
  • Chen, J., Liu, W., Zhang, F., Lacy, L., Yang, X., Song, S., Wickline, S., & Yu, X. (2005). Regional ventricular wall thickening reflects changes in cardiac fiber and sheet structure during contraction: quantification with diffusion tensor MRI.. American journal of physiology. Heart and circulatory physiology, 289 (5), H1898-907.
  • Ashford, Jr, M., Liu, W., Karabalin, R., Abraszewski, P., Caruthers, S., Connolly, A., Yu, X., & Wickline, S. (2005). Occult cardiac contractile dysfunction in dystrophin-deficient children revealed by cardiac magnetic resonance strain imaging.. Circulation, 112 (16), 2462-7.
  • Morawski, A., Winter, P., Yu, X., Fuhrhop, R., Scott, M., Hockett, F., Robertson, J., Gaffney, P., Lanza, G., & Wickline, S. (2004). Quantitative "magnetic resonance immunohistochemistry" with ligand-targeted (19)F nanoparticles.. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 52 (6), 1255-62.
  • Liu, W., Chen, J., Ji, S., Allen, J., Bayly, P., Wickline, S., & Yu, X. (2004). Harmonic phase MR tagging for direct quantification of Lagrangian strain in rat hearts after myocardial infarction.. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 52 (6), 1282-90.
  • Chen, J., Song, S., Liu, W., McLean, M., Allen, J., Tancabel, J., Wickline, S., & Yu, X. (2003). Remodeling of cardiac fiber structure after infarction in rats quantified with diffusion tensor MRI.. American journal of physiology. Heart and circulatory physiology, 285 (3), H946-54.
  • Winter, P., Caruthers, S., Yu, X., Song, S., Chen, J., Miller, B., Bulte, J., Robertson, J., Gaffney, P., Wickline, S., & Lanza, G. (2003). Improved molecular imaging contrast agent for detection of human thrombus.. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 50 (2), 411-6.
  • Lanza, G., Yu, X., Winter, P., Abendschein, D., Karukstis, K., Scott, M., Chinen, L., Fuhrhop, R., Scherrer, D., & Wickline, S. (2002). Targeted antiproliferative drug delivery to vascular smooth muscle cells with a magnetic resonance imaging nanoparticle contrast agent: implications for rational therapy of restenosis.. Circulation, 106 (22), 2842-7.
  • Lanza, G., Abendschein, D., Yu, X., Winter, P., Karukstis, K., Scott, M., Fuhrhop, R., Scherrer, D., & Wickline, S. (2002). Molecular imaging and targeted drug delivery with a novel, ligand-directed paramagnetic nanoparticle technology.. Academic radiology, 9 Suppl 2 , S330-1.
  • Yu, X., Song, S., Chen, J., Scott, M., Fuhrhop, R., Hall, C., Gaffney, P., Wickline, S., & Lanza, G. (2000). High-resolution MRI characterization of human thrombus using a novel fibrin-targeted paramagnetic nanoparticle contrast agent.. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 44 (6), 867-72.
  • O'Donnell, J., Doumen, C., LaNoue, K., White, N., Yu, X., Alpert, N., & Lewandowski, E. (1998). Dehydrogenase regulation of metabolite oxidation and efflux from mitochondria in intact hearts.. The American journal of physiology, 274 (2 Pt 2), H467-76.
  • Lewandowski, E., Yu, X., LaNoue, K., White, N., Doumen, C., & O'Donnell, J. (1997). Altered metabolite exchange between subcellular compartments in intact postischemic rabbit hearts.. Circulation research, 81 (2), 165-75.
  • Yu, X., Alpert, N., & Lewandowski, E. (1997). Modeling enrichment kinetics from dynamic 13C-NMR spectra: theoretical analysis and practical considerations.. The American journal of physiology, 272 (6 Pt 1), C2037-48.
  • Yu, X., White, N., Alpert, N., & Lewandowski, E. (1996). Subcellular metabolite transport and carbon isotope kinetics in the intramyocardial glutamate pool.. Biochemistry, 35 (21), 6963-8.
  • Damico, L., White, N., Yu, X., & Lewandowski, E. (1996). Chemical versus isotopic equilibrium and the metabolic fate of glycolytic end products in the heart.. Journal of molecular and cellular cardiology, 28 (5), 989-99.
  • Lewandowski, E., Doumen, C., White, N., LaNoue, K., Damico, L., & Yu, X. (1996). Multiplet structure of 13C NMR signal from glutamate and direct detection of tricarboxylic acid (TCA) cycle intermediates.. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 35 (2), 149-54.
  • Yu, X., White, N., Doumen, C., Damico, L., LaNoue, K., Alpert, N., & Lewandowski, E. (1995). Kinetic analysis of dynamic 13C NMR spectra: metabolic flux, regulation, and compartmentation in hearts.. Biophysical journal, 69 (5), 2090-102.
  • Lewandowski, E., Damico, L., White, N., & Yu, X. (1995). Cardiac responses to induced lactate oxidation: NMR analysis of metabolic equilibria.. The American journal of physiology, 269 (1 Pt 2), H160-8.
  • Yu, X., & Gu, Y. (). Assessing tissue metabolism by phosphorous-31 magnetic resonance spectroscopy and imaging: a methodology review. Quant Imaging Med Surg., 7 (6), 707-726.

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Education

Doctor of Science
Radiological Sciences,
Harvard-MIT Division of Health Sciences and Technology
Master of Science
Electrical Engineering
The Johns Hopkins University
Bachelor of Science
Electrical Engineering
University of Science and Technology, Hefei, Anhui, China

Residencies, Internships and Fellowships

Post-Doctoral Fellowship
Duke University

Additional Information