Molecular imaging, defined as the in vivo characterization of biological processes at the cellular and molecular level, is an attempt to image the molecular make-up of the macrofeatures currently visualized using "classical" diagnostic imaging techniques. Classically, detection of malignant tumor cells in a background of normal or hyperplastic benign tissue is often based on differences in physical properties between tissues, which are frequently minimal, resulting in low contrast resolution
My laboratory concentrates on research related to the development and application of Molecular Imaging technologies. Specifically we are interested in designing novel imaging tools to image individual and multiple molecular markers of disease. We believe that imaging tissues based on the underlying molecular rather than macromolecular differences will result in a substantial increase in the sensitivity and specificity of medical imaging. Some areas of active research include defining "molecular signatures" of disease, developing paradigms to image multiple markers of disease simultaneously, developing methods to image intracellular disease markers in breast cancer, and developing molecular imaging technologies that allow for intraoperative assessment of disease progression.
Awards and Honors
- Biocompatible Nanoparticles of Coordination Polymer KGd (H2O) 2 [Fe (CN) 6]• H2O with Extremely High T1-Weighted Relaxivity: Towards Stable Cellular MR Probes Containing Two Coordinated Water Molecules on the Gd (III) Center; Vindya S Perera, Liu D Yang, Jihua Hao, Guojun Chen, Bernadette O Erokwu, Chris A Flask, Peter Y Zavalij, James P Basilion, Songping D Huang – 2014
- Molecular imaging of tumor-associated cathepsins: implication for rapid detection of human nonmelanoma skin cancer; Ethan Walker, Margaret Mann, Galia Blum, Matthew Bogyo, James P Basilion – 2014
- Peptide‐Targeted Gold Nanoparticles for Photodynamic Therapy of Brain Cancer; Joseph D Meyers, Yu Cheng, Ann‐Marie Broome, Richard S Agnes, Mark D Schluchter, Seunghee Margevicius, Xinning Wang, Malcolm E Kenney, Clemens Burda, James P Basilion - 2014