Xin Yu, ScD

F. Alex Nason Professor II of Biomedical Engineering
Department of Biomedical Engineering
Case School of Engineering, School of Medicine
Department of Physiology and Biophysics
School of Medicine
Department of Radiology
School of Medicine

Research Information

Research Interests

  • Magnetic resonance imaging and spectroscopy
  • In vivo metabolic imaging in diabetes and stroke
  • Magnetic resonance fingerprinting in pre-clinical studies

Our laboratory is devoted to the development of magnetic resonance imaging (MRI) and spectroscopic imaging (MRSI) methods for integrative understanding of several prevalent diseases such as diabetes, stroke, and heart diseases.  These diseases share a common underlying cause - metabolic dysfunction. We aim to develop state-of-the-art MRI and MRSI methods for noninvasive characterization of various aspects of tissue metabolism, from substrate delivery to oxygen utilization.  Some of these technologies hold the potential for early detection of metabolic dysfunction.  We also collaborate with investigators in basic science research to apply these technologies to laboratory animal models, including genetically engineered mouse models, for better understanding of the mechanisms leading to abnormal metabolism, and the response to therapeutic interventions.

For more information visit Xin Yu's lab website.

Awards and Honors

Research Award
Case Western Reserve University School of Engineering
Clement Vaturi Fellowship in Biomedical Engineering
Massachusetts Institute of Technology
Clement Vaturi Fellowship in Biomedical Engineering
Massachusetts Institute of Technology
Wolkman Fellowship of W.G.C. Whiting School of Engineering
The Johns Hopkins University
Wolkman Fellowship of W.G.C. Whiting School of Engineering
The Johns Hopkins University
American Institute for Medical and Biological Engineering (AIMBE)

Professional Memberships

International Society of Magnetic Resonance in Medicine
American Association for the Advancement of Science
American Heart Association
American Diabetes Association
International Society of Cerebral Blood Flow and Metabolism


  • B Clifford, Y Gu, Y Li, Y Liu, K Kim, S Huang, Y Li, F Lam, Z-P Liang, X Yu.  High-resolution dynamic 31P-MR spectroscopic imaging for mapping mitochondrial function. IEEE TBME, 67:2745-2753, 2020. PMID: 32011244
  • Y Zhang, K Xu, Y Liu, BO Erokwu, P Zhao, JC LaManna, GW Farr, CA Flask, WF Boron, X Yu.  Increased cerebral vascularization in response to decreased water exchange across the blood-brain barrier in aquaporin-4 knockout mice. PLOS ONE, 14:e0218415, 2019. PMID: 31220136
  • Y Gu, C Wang, C Anderson, Y Liu, H Hu, ML Johansen, D Ma, Y Jiang, C Ramos-Estebanez, S Brady-Kalnay, MA Griswold, CA Flask, and X Yu.  Fast magnetic resonance fingerprinting for dynamic contrast-enhanced studies in mice.  Magn. Reson. Med., 80:2681-2690, 2018.  PMID: 29744935
  • CY Wang, Y Liu, S Huang, MA Griswold, N Seiberlich, X Yu.  31P magnetic resonance fingerprinting for rapid quantification of creatine kinase reaction rate in vivo. NMR in Biomed., 30:e3786, 2017. PMID: 28915341

View full list of publications. 


Doctor of Science
Radiological Sciences,
Harvard-MIT Division of Health Sciences and Technology
Master of Science
Electrical Engineering
The Johns Hopkins University
Bachelor of Science
Electrical Engineering
University of Science and Technology, Hefei, Anhui, China

Residencies, Internships and Fellowships

Post-Doctoral Fellowship
Duke University

Additional Information