Faculty Director
Case School of Engineering
M. Frank and Margaret Domiter Rudy Professor of Biomedical Engineering
Department of Biomedical Engineering
Case School of Engineering
School of Medicine
Member
Cancer Imaging Program
Case Comprehensive Cancer Center
Member
CWRU Center for Imaging Research
Teaching Information
Teaching Interests
- Drug delivery
- Molecular imaging
- Nanomedicine
- Biomolecular Engineering
Research Information
Research Interests
- Novel MRI contrast agents
- Molecular imaging
- Drug delivery
- Therapeutics for treating retinal diseases
- Gene delivery
- Nanomedicine
Research Projects
Our laboratory focuses on molecular imaging and drug delivery using novel nanotechnology. We are interested in using biodegradable materials and organic nanomaterials to design and develop targeted, safe and effective imaging agents and drug delivery systems for diagnostic imaging, treatment of human diseases and image-guided therapy.
Our ongoing research projects include:
- Biodegradable macromolecular MRI contrast agents that can be used for contrast enhanced cardiovascular and cancer MRI
- Targeted nanoglobules with well defined sizes
External Appointments
- 2017 - PRESENT, Founder, Board Member (or Manager), Chief Scientific Officer, U.S. Motek, LLC
- 2017 - PRESENT, Founder, Chair of Board of Directors, President China Jiansu Motek, Inc.,
- 2014 - PRESENT, Founder, Board Member (or Manager), Chief Scientific Officer Molecular Theranostics, LLC,
Publications
- Lu, ZR. Theranostics: Fusion of Therapeutics and Diagnostics. Pharm Res (2014) 31: 1355.
- Jin E, Lu ZR. Biodegradable iodinated polydisulfides as contrast agents for CT angiography. Biomaterials. 2014, 35, 5822-5829.
- Wu X, Yu G, Luo C, Maeda A, Zhang N, Sun D, Zhou Z, Puntel A, Palczewski K, Lu ZR. Synthesis and evaluation of a nanoglobular dendrimer 5-aminosalicylic Acid conjugate with a hydrolyzable schiff base spacer for treating retinal degeneration. ACS Nano. 2014, 8, 153-161.
Education
Doctor of Philosophy
Chinese Academy of Sciences, China
Master of Science
Lanzhou University, Lanzhou China
Bachelor of Science
Lanzhou University, Lanzhou China
Residencies, Internships and Fellowships
Postdoctoral
University of Utah, Salt Lake City
Postdoctoral
Wuhan University, Wuhan China