Andrei Maiseyeu, Ph.D.
Dr. Maiseyeu’s education and training is originally in organic chemistry. His postdoctoral training was at the Ohio State School of Medicine in cardiovascular biomedicine, during which he was involved in both developing new nanomaterials for drug delivery and studying the environment in the context of air pollution. Dr. Maiseyeu is now an Associate Professor at Case Western Reserve University at both the School of Medicine and the Department of Biomedical Engineering. His laboratory, funded by the federal government (National Institutes of Health), industry and foundations, including Alzheimer’s Association, have been focusing on translational research. His lab is developing tools, probes and treatments targeting inflammation in various diseases including neurological and cardiovascular disease. Throughout his career as an independent investigator, Dr. Maiseyeu trained more than 25 students and postdoctoral researchers, many of whom have been recipients of various awards and grants. Many of his trainees pursued careers in academic research, medicine, and industry including Janssen, Regeneron, MedStar, and other companies and prestigious medical centers around the US. Dr. Maiseyeu is a member of the ad hoc reviewer committee for the Catalyze at National Institutes of Health grant program, a specially designed funding opportunity that helps to transform basic scientific discoveries into medicines that help patients.
Publications:
Di L, Thomas A, Switala L, Kalikasingh K, Lapping S, Nayak L, Maiseyeu A. Surface Geometry of Cargo-less Gold Nanoparticles Is a Driving Force for Selective Targeting of Activated Neutrophils to Reduce Thrombosis in Antiphospholipid Syndrome. Nano Lett. 2023;23:9690–9696.
Maiseyeu A, Di L, Ravodina A, Barajas-Espinosa A, Sakamoto A, Chaplin A, Zhong J, Gao H, Mignery M, Narula N, Finn AV, Rajagopalan S. Plaque-targeted, proteolysis-resistant, activatable and MRI-visible nano-GLP-1 receptor agonist targets smooth muscle cell differentiation in atherosclerosis. Theranostics. 2022;12:2741–2757.
Nayak L, Sweet DR, Thomas A, Lapping SD, Kalikasingh K, Madera A, Vinayachandran V, Padmanabhan R, Vasudevan NT, Myers JT, Huang AY, Schmaier A, Mackman N, Liao X, Maiseyeu A, Jain MK. A targetable pathway in neutrophils mitigates both arterial and venous thrombosis. Sci Transl Med. 2022;14:eabj7465.
Bagalkot V, Deiuliis JA, Rajagopalan S, Maiseyeu A. “Eat me” imaging and therapy. Adv Drug Deliv Rev. 2016;99:2–11.
Education:
Bachelor and Master of Science, Organic Chemistry, MV Lomonosov Moscow State University, 2004
PhD in Organic Chemistry, MV Lomonosov Moscow State University, 2007
Lauren Switala, M.S., Ph.D. Candidate
Lauren is pursuing her PhD in biomedical engineering at Case Western Reserve University (CWRU). She holds a master’s of biomedical engineering from CWRU, a master’s of chemistry from the University of Oregon, and a bachelor’s of chemistry from Rochester Institute of Technology. Her research at CWRU is focused on facilitating gene therapy in the heart by use of polymer-based nanoparticles. Her previous research interests include solid state nuclear magnetic resonance and developing amorphous solid dispersions as oral pharmaceutical formulations.
Publications:
Switala, L. E., Ryan, W. J., Hoffman, M., Brown, W. & Hornak, J. P. Low Frequency EPR and EMR Point Spectroscopy and Imaging of a Surface. Magn. Reson. Imaging 34, 469–472 (2016).
Ero, M. et al. Thromboelastography and the Functional Confirmation of Heparin-Induced Thrombocytopenia in Donor Whole Blood. Blood 128, 4924–4924 (2016).
Switala, L. E., Black, B. E., Mercovich, C. A., Seshadri, A. & Hornak, J. P. An electron paramagnetic resonance mobile universal surface explorer. J. Magn. Reson. 285, 18–25 (2017).
Shepard, K. B. et al. Local Treatment of Non-small Cell Lung Cancer with a Spray-Dried Bevacizumab Formulation. AAPS PharmSciTech 22, 230 (2021).
Di, L. et al. Surface Geometry of Cargo-less Gold Nanoparticles Is a Driving Force for Selective Targeting of Activated Neutrophils to Reduce Thrombosis in Antiphospholipid Syndrome. Nano Lett. 23, 9690–9696 (2023).
Education:
Bachelor of Science, Chemistry, Rochester Institute of Technology, 2015
Master of Science, Chemistry, University of Oregon, 2018
Master of Science, Biomedical Engineering, Case Western Reserve University, 2024
Lin Di, Ph.D. Candidate
Lin received her B.S. degree in biomedical engineering at the University of Iowa and is currently pursuing Ph. D. in biomedical engineering at Case Western Reserve University. Her previous research encompassed immunotherapy for wound healing in type 2 diabetes using mesenchymal stem cells. At CWRU, her research is centered on targeted immunotherapy for cardiovascular diseases utilizing nanoparticles.
Publications:
Di L, Thomas A, Switala L, Kalikasingh K, Lapping S, Nayak L, Maiseyeu A. Surface Geometry of Cargo-less Gold Nanoparticles Is a Driving Force for Selective Targeting of Activated Neutrophils to Reduce Thrombosis in Antiphospholipid Syndrome. Nano Lett. 2023;23:9690–9696.
Maiseyeu A, Di L, Ravodina A, Barajas-Espinosa A, Sakamoto A, Chaplin A, Zhong J, Gao H, Mignery M, Narula N, Finn AV, Rajagopalan S. Plaque-targeted, proteolysis-resistant, activatable and MRI-visible nano-GLP-1 receptor agonist targets smooth muscle cell differentiation in atherosclerosis. Theranostics. 2022;12:2741–2757.
Di L, Maiseyeu A. Low-density lipoprotein nanomedicines: mechanisms of targeting, biology, and theranostic potential. Drug Deliv. 2021 Dec;28(1):408-421. doi: 10.1080/10717544.2021.1886199. Review. PubMed PMID: 33594923; PubMed Central PMCID: PMC7894439.
Burand AJ Jr, Di L, Boland LK, Boyt DT, Schrodt MV, Santillan DA, Ankrum JA. Aggregation of Human Mesenchymal Stromal Cells Eliminates Their Ability to Suppress Human T Cells. Front Immunol. 2020;11:143. doi: 10.3389/fimmu.2020.00143. eCollection 2020. PubMed PMID: 32158443; PubMed Central PMCID: PMC7052295.
Boland LK, Burand AJ, Boyt DT, Dobroski H, Di L, Liszewski JN, Schrodt MV, Frazer MK, Santillan DA, Ankrum JA. Nature vs. Nurture: Defining the Effects of Mesenchymal Stromal Cell Isolation and Culture Conditions on Resiliency to Palmitate Challenge. Front Immunol. 2019;10:1080. doi: 10.3389/fimmu.2019.01080. eCollection 2019. PubMed PMID: 31134100; PubMed Central PMCID: PMC6523025.
Awards and honors
AHA predoctoral fellowship, Jab. 2022–Dec. 2023
Education:
Bachelor of Science, Biomedical Engineering, the University of Iowa, 2018
Natalie Hong, M.D./Ph.D. Candidate
Natalie graduated with a B.S. in Biomedical and Chemical Engineering from Carnegie Mellon University and presented an undergraduate research thesis on programming robotic tools for proteomics research. She completed a postbaccalaureate year at the National Institutes of Health studying drug evaluation and delivery for cancer. In the Maiseyeu Laboratory, she is evaluating the epigenetic effects of immunomodulatory metabolites and developing orally-bioavailable therapeutics to regulate cholesterol and inflammation.
Publications:
Andrew Mikhail, Michal Mauda-Havakuk, Ayele H Negussie, Natalie Hong, Natalie Hawken, Camella J Carlson, Joshua W Owen, Olga Franco-Mahecha; Paul G Wakim, Andrew L Lewis, William F Pritchard, John W Karanian, Bradford J Wood. 2022. “Evaluation of Immune-Modulating Drugs for Use in Drug-eluting Microsphere Transarterial Embolization.” International Journal of Pharmaceutics. PMCID: PMC9139086
Ayele H Negussie, Andrew S Mikhail, Joshua W Owen, Natalie Hong, Camella J Carlson, Yiqing Tang, Kendal Paige Carrow, Michal Mauda-Havakuk, Andrew L Lewis, John W Karanian, William F Pritchard, Bradford J Wood. “In vitro characterization of immune modulating drug-eluting immunobeads towards transarterial embolization in cancer.” Scientific Reports. PMCID: PMC9981694
Vinayak Narasimhan, Radwanul Hasan Siddique, Jeong Oen Lee, Shailabh Kumar, Blaise Ndjamen, Juan Du, Natalie Hong, David Sretavan, and Hyuck Choo. 2018. “Multifunctional Biophotonic Nanostructures Inspired by the Longtail Glasswing Butterfly for Medical Devices.” Nature Nanotechnology 13 (6): 512–19. PMCID: PMC5992053
Education:
Bachelor of Science, Biomedical and Chemical Engineering, Carnegie Mellon University, 2018
Oleksandra Pavlova, PhD
Oleksandra obtained BS and MSc in physiology. During her PhD training she worked in cardiovascular pathologies focusing on smooth muscles and endothelium involvement. Later on, she continued to investigate mechanisms of hypertension generated by gamma-irradiation and diabetes. She obtained wide experience in the pharma industry – new drug patenting, certification, and preclinical study (in vivo) such as toxicity, efficacy, and safety. Now her focus is Alzheimer's disease experimental treatment development involving epigenetic modification.
Publications:
Pavlova O.O., Kizub I.V., Soloviev A.I. The role of endothelium in formation of blood vessel’s wall contraction response under hypoxia. Med. Chem. V.3, 103-106 (2003).
Soloviev A.I., et al. Ionizing radiation alters myofilament calcium sensitivity in vascular smooth muscle: Potential role of protein kinase C. Am. J. Physiol. Regul. Inegr. Comp. Physiol. V.289, R755-R762 (2005).
Kizub I.V., Pavlova A.A., Soloviev А.І. Protein kinase C modulates myofilaments Ca2+ - sensitivity in vascular smooth muscle: possible role in vasospasm development. J. Muscl. Res. Cell Motil. V.26(1), 70 (2005).
Kizub I.V., Pavlova O.O., Johnson C.D., Soloviev A.I., Zholos A.V. Protein kinase C and Rho kinase involvement in vascular smooth muscle myofilament calcium sensitization in arteries from diabetic rats. British Journal of Pharmacology. V.159(8), 1724-1731 (2010).
Kizub I.V., Johnson C.D., Pavlova O.O., Soloviev A.I., Zholos A.V. Effects of Rho Kinase inhibitor an adrenergic and calcium sensitivity in vascular smooth muscle associated with diabetes mellitus. Journal of Hypertension; 28:p. e290-291 (2010).
Fominova K., et al. Oxa-spirocycles: synthesis, properties and applications. Chem Sci 12(34):11294-11305 (2021).
Awards and Honors:
Junior Fellowship, Physiological Society, UK, 2005-2007.
Education:
Bachelor of Science, Biology, Taras Shevchenko National University of Kyiv, 1999.
Master of Science, Human and Animals’ Physiology, Taras Shevchenko National University of Kyiv, 2000.
PhD in Experimental Pharmacology, Institute of Pharmacology and Toxicology, Kyiv, 2005.
Alondra Barajas, Undergraduate Student
Alondra is from Westchester County, New York and is a third year undergraduate here at CWRU. She is majoring in Biochemistry and minoring in Spanish and Chemistry. Outside of the lab she likes to volunteer, read, and go on runs.