Pioneering genomic approaches for querying epigenetics and transcriptional regulation on metabolic alteration (Insulin resistance, Type2 diabetes and Cardiovascular disease) induced by air pollution in animal models. My focus is on to identify the role of chromatin dynamics and transcriptional changes associated with metabolic dysregulation upon air pollution exposure and integrating multidisciplinary approaches involving circadian rhythm, biochemistry, molecular biology, and cell biology, along with next generation sequencing and bioinformatics.
Awards and Honors
Palanivel R, Vinayachandran V, Biswal S, Deiuliis JA, Padmanabhan R, Park B, Gangwar RS, Durieux JC, Ebreo Cara EA, Das L, Bevan G, Fayad ZA, Tawakol A, Jain MK, Rao S, Rajagopalan S. Exposure to Air Pollution Disrupts Circadian Rhythm through Alterations in Chromatin Dynamics. (2020). iScience (2020) 23:101728.
Rajagopalan S, Park B, Palanivel R, Vinayachandran V, Deiuliis JA, Gangwar RS, Das L, Yin J, Choi Y, Al-Kindi S, Jain MK, Hansen KD, Biswal S. Metabolic effects of air pollution exposure and reversibility. J Clin Invest. (2020)130:6034-6040
Gangwar RS, Vinayachandran V, Palanivel R, Chan R, Park B, Diamond-Zaluski R, Cara EA, Cha A, Das L, Asase C, Maiseyeu A, Deiuliis J, Zhong J, Mitzner W, Biswal S, Rajagopalan S. Differential contribution of bone marrow-derived infiltrating monocytes and resident macrophages to persistent lung inflammation in chronic air pollution exposure. Sci Rep. (2020)1:14348.
Chaplin A, Gao H, Asase C, Palanivel R, Park B, Skander D, Bebek G, Rajagopalan S, Maiseyeu A. Publisher Correction: Systemically-delivered biodegradable PLGA alters gut microbiota and induces transcriptomic reprogramming in the liver in an obesity mouse model. Sci Rep. (2020) 24:16010
Crane JD, Palanivel R (co-first author), Mottillo EP, Bujak AL, Wang H, Ford RJ, Collins A, Blümer RM, Fullerton MD, Yabut JM, Kim JJ, Ghia JE, Hamza SM, Morrison KM, Schertzer JD, Dyck JR, Khan WI, Steinberg GR. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nature Medicine. (2015) 21:166-72.
Palanivel R, Ganguly R, Turdi S, Xu A, Sweeney G. Adiponectin stimulates Rho-mediated actin cytoskeleton remodeling and glucose uptake via APPL1 in primary cardiomyocytes. Metabolism. (2014) 63:1363-73
Fullerton. MD, Galic. Marcinko .SK, Sikkema S, Pulinilkunnil.T, Chen. ZP, Palanivel. R, O’Neill. HM, Schertzer JD, O’Brien. M, Hardie. DG, Macaulay. L, van Denderen. BJ, Dyck. JR, Kemp. BE, Steinberg GR.A single amino acid in ACC1 and 2 is essential for lipid homeostasis and the therapeutic effects of metformin. Nature Medicine (2013) 19:1649-54
Palanivel. R, Fullerton MD, Galic. S, Honeyman. J, Hewitt. KA, Jorgensen. SB, and Steinberg. GR. Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance. Diabetologia (2012) 55: 3083-3093
Palanivel R, Vu V, Park M, Fang X, Sweeney G. Differential impact of adipokines derived from primary adipocytes of wild-type versus Streptozotocin diabetic rats on glucose and fatty acid metabolism in cardiomyocytes. J Endocrinol, (2008) 199: 387-395
Palanivel. R, Fang. X, Park. M, Eguchi. M, Pallan. S, De Girolamo. S, Liu. Y, Wang. Y, Xu. A and Sweeney G. Globular and full-length form of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes Cardiovascular Research (2007) 75: 148-157
Palanivel. R, Eguchi. M, Shuralyova I, Coe I and Sweeney G. Distinct effects of short and long term leptin treatment on glucose and fatty acid uptake and metabolism in HL-1 cardiomyocytes Metabolism Clinical and Experimental (2006) 8: 1067-1075
Palanivel. R, Maida. M, Liu.Y and Sweeney G. Regulation of insulin signaling, glucose uptake and metabolism in rat skeletal muscle cells upon prolonged exposure to resistin. Diabetologia (2006) 49: 183-190
Palanivel R and Sweeney G. Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by resistin. FEBS Letters (2005) 579: 5049-5054
Waliul Khan, Gregory Steinberg, Rengasamy Palanivel, inventors; McMaster University, assignee; A method of treating obesity. United States patent US 9,937,173. 2018 April 10.