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Yuan Lu

Research Information

Research Interests

My research bridges molecular biology, cellular biology and animal model study to gain new insights into pathophysiology of cardiovascular diseases and metabolic diseases, identify biomarkers and discover novel drug targets.

    Research Projects

    My currently research projects include:

    1. The role of Kruppel Like Factor 15 in white adipocyte lipid handling
    2. Mitophagy in brown adipose tissue mitochondrial homeostasis
    3. Targeting Myeloperoxidase in cardiovascular diseases

    Publications

    1. KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting. Takeuchi Y, Yahagi N, Aita Y, Murayama Y, Sawada Y, Piao X, Toya N, Oya Y, Shikama A, Takarada A, Masuda Y, Nishi M, Kubota M, Izumida Y, Yamamoto T, Sekiya M, Matsuzaka T, Nakagawa Y, Urayama O, Kawakami Y, Iizuka Y, Gotoda T, Itaka K, Kataoka K, Nagai R, Kadowaki T, Yamada N, Lu Y, Jain MK, Shimano H. Cell Rep. 2016 Aug 30;16(9):2373-86
    2. Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis. Liao X, Zhang R, Lu Y, Prosdocimo DA, Sangwung P, Zhang L, Zhou G, Anand P, Lai L, Leone TC, Fujioka H, Ye F, Rosca MG, Hoppel CL, Schulze PC, Abel ED, Stamler JS, Kelly DP, Jain MK. J Clin Invest. 2015 Sep;125(9):3461-76.
    3. Kruppel-like factor 15 is critical for vascular inflammation. Lu Y, Zhang L, Liao X, Sangwung P, Prosdocimo DA, Zhou G, Votruba AR, Brian L, Han YJ, Gao H, Wang Y, Shimizu K, Weinert-Stein K, Khrestian M, Simon DI, Freedman NJ, Jain MK. J Clin Invest. 2013 Oct;123(10):4232-41.
    4. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK. Nature. 2012 Feb 22;483(7387):96-9. doi: 10.1038/nature10852.
    5. Myeloid Krüppel-like factor 4 deficiency augments atherogenesis in ApoE-/- mice. Sharma N, Lu Y, Zhou G, Liao X, Kapil P, Anand P, Mahabeleshwar GH, Stamler JS, Jain MK.Arteriosclerosis, thrombosis, and vascular biology. 2012; 32(12):2836-8.
    6. Kruppel-like factor 15 regulates smooth muscle response to vascular injury. Lu Y, Haldar S, Croce K, Wang Y, Sakuma M, Morooka T, Wang B, Jeyaraj D, Gray SJ, Simon DI, Jain MK. Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1550-2.
    7. Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation. Haldar SM, Lu Y, Jeyaraj D, Kawanami D, Cui Y, Eapen SJ, Hao C, Li Y, Doughman YQ, Watanabe M, Shimizu K, Kuivaniemi H, Sadoshima J, Margulies KB, Cappola TP, Jain MK. Sci Transl Med. 2010 Apr 7;2(26):26ra26.
    8. Uterine artery myosin phosphatase isoform switching and increased sensitivity to SNP in a rat L-NAME model of hypertension of pregnancy.  Lu Y, Zhang H, Gokina N, Mandala M, Sato O, Ikebe M, Osol G, Fisher SA.  Am J Physiol Cell Physiol. 2008 Feb; 294(2):C564-71

    Education

    Doctor of Medicine
    Ningxia Medical University (China)
    1994
    Master of Science
    Molecular Pharmacology
    Chinese Academy of Medical Science & Peking Union Medical College (PUMC)
    2000

    Residencies, Internships and Fellowships

    Postdoctoral Fellow
    Case Western Reserve University
    2004
    Research Associate
    Case Western Reserve University
    2006

    Additional Information

    2002-2004: Research Scientist, National Engineer Research Center and Capital Biochip Corporation,Tsing Hua University, Beijing, China