SPICES Research

Current Work

Explore some of our ongoing projects that demonstrate the SPICES approach in action:

  • Powered by cutting-edge AI/ML techniques, we investigate the intricate socio-environmental factors contributing to cardiometabolic risk. Our research offers unparalleled insights into individual patient risk profiles, thanks to the integration of a distinctive dataset from the University Hospital's no-cost Coronary Artery Calcium (CAC) testing initiative, known as CLARIFY


SPICES thrives on collaboration. We have forged strong partnerships with the Core Labs in Heart and Vascular Research at University Hospital Harrington Heart & Vascular Institute, the Cardiovascular Research Institute at Case Western Reserve University's School of Medicine, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, and Cardiovascular Prevention and Wellness, Houston Methodist.


Motairek, I., Dong, W., Salerno, P.R., Janus, S.E., Ganatra, S., Chen, Z., Guha, A., Makhlouf, M.H., Hassani, N.S., Rajagopalan, S. and Al-Kindi, S.G., 2023. Geographical patterns and risk factor association of cardio-oncology mortality in the United States. The American Journal of Cardiology, 201, pp.150-157.

Motairek, I., Deo, S.V., Elgudin, Y., McAllister, D.A., Brook, R.D., Chen, Z., Su, J., Rao, S.V., Rajagopalan, S. and Al-Kindi, S., 2023. Particulate matter air pollution and long-term outcomes in patients undergoing percutaneous coronary intervention. JACC: Advances2(3), p.100285.

Motairek, I., Chen, Z., Makhlouf, M.H., Rajagopalan, S. and Al-Kindi, S., 2023. Historical neighbourhood redlining and contemporary environmental racism. Local Environment, 28(4), pp.518-528.

Dong, W., Motairek, I., Nasir, K., Chen, Z., Kim, U., Khalifa, Y., Freedman, D., Griggs, S., Rajagopalan, S. and Al-Kindi, S.G., 2023. Risk factors and geographic disparities in premature cardiovascular mortality in US counties: a machine learning approach. Scientific Reports, 13(1), p.2978.

Makhlouf, M.H., Motairek, I., Chen, Z., Nasir, K., Deo, S.V., Rajagopalan, S. and Al-Kindi, S.G., 2022. Neighborhood Walkability and Cardiovascular Risk in the United States. Current Problems in Cardiology, p.101533