Reena Mehra, MD

Department of Medicine
School of Medicine

Reena Mehra is director of sleep disorders research in the Sleep Center of the Neurological Institute at Cleveland Clinic. She is a Cleveland Clinic staff physician and associate professor of medicine at Case Western Reserve University School of Medicine. Her research involves investigating the relationship between sleep-disordered breathing and abnormal cardiac electrophysiology. She also studies cardiovascular disease as it relates to sleep disorders in clinical trials and epidemiological analyses.

Research Information

Research Interests

External Appointments

Director of Sleep Disorders Research, Sleep Disorders Center
Neurological Institute, Cleveland Clinic
Cleveland FES Center


Selected Publications

Mehra R, Wang L, Andrews N, Tang WHW, Young JB, Javaheri S, Foldvary-Schaefer N. Dissociation of Objective and Subjective Daytime Sleepiness and Biomarkers of Systemic Inflammation in Sleep-Disordered Breathing and Systolic Heart Failure. J Clin Sleep Med. 2017 Dec 15;13(12):1411–1422. doi: 10.5664/jcsm.6836 Pubmed PMID: 29065958

Walia HK, Thompson NR, Katzan I, Foldvary-Schaefer N, Moul DE, Mehra R. Impact of Sleep-Disordered Breathing Treatment on Quality of Life Measures in a Large Clinic-Based Cohort. J Clin Sleep Med. 2017 Nov 15;13(11):1255–1263. doi: 10.5664/jcsm.6792 Pubmed PMID: 28992832

Mehra R. Sleep Apnea and Nocturnal Cardiac Arrhythmia: Understanding Differences Across Ethnicity. J Clin Sleep Med. 2017 Nov 15;13(11):1229–1231. doi: 10.5664/jcsm.6784 Pubmed PMID: 29065964

Kaw R, Mehra R. Sleep disordered breathing and post-cardiac surgery atrial fibrillation. J Thorac Dis. 2017 Sep;9(9):E867–E868. doi: 10.21037/jtd.2017.08.105 Pubmed PMID: 29221363

Zhao YY, Mehra R. Biomarkers in Sleep Apnea and Heart Failure. Curr Heart Fail Rep. 2017 Aug;14(4):284–300. doi: 10.1007/s11897-017-0339-7 Pubmed PMID: 28667490

Tung P, Levitzky YS, Wang R, Weng J, Quan SF, Gottlieb DJ, Rueschman M, Punjabi NM, Mehra R, Bertisch S, Benjamin EJ, Redline S. Obstructive and Central Sleep Apnea and the Risk of Incident Atrial Fibrillation in a Community Cohort of Men and Women. J Am Heart Assoc. 2017 Jul 1;6(7). doi: 10.1161/JAHA.116.004500 Pubmed PMID: 28668820

Lewis EF, Wang R, Punjabi N, Gottlieb DJ, Quan SF, Bhatt DL, Patel SR, Mehra R, Blumenthal RS, Weng J, Rueschman M, Redline S. Impact of continuous positive airway pressure and oxygen on health status in patients with coronary heart disease, cardiovascular risk factors, and obstructive sleep apnea: A Heart Biomarker Evaluation in Apnea Treatment (HEARTBEAT) analysis. Am Heart J. 2017 Jul;189:59–67. doi: 10.1016/j.ahj.2017.03.001 Pubmed PMID: 28625382

Bernstein AM, Allexandre D, Bena J, Doyle J, Gendy G, Wang L, Fay S, Mehra R, Moul D, Foldvary-Schaefer N, Roizen MF, Drerup M. “Go! to Sleep”: A Web-Based Therapy for Insomnia. Telemed J E Health. 2017 Jul;23(7):590–599. doi: 10.1089/tmj.2016.0208 Pubmed PMID: 28112590

Xu B, Mehra R. The hemodynamic impact of acute nasal continuous positive airway pressure treatment in hypertrophic cardiomyopathy: is it safe? J Thorac Dis. 2017 Jun;9(6):1409–1411. doi: 10.21037/jtd.2017.05.20 Pubmed PMID: 28740644

Mehra R, Foldvary-Schaefer N. The USPSTF and screening for obstructive sleep apnea: Dispelling misconceptions. Cleve Clin J Med. 2017 Jun;84(6):429–431. doi: 10.3949/ccjm.84a.17023 Pubmed PMID: 28628426

Kaw R, El Zarif S, Wang L, Bena J, Blackstone EH, Mehra R. Obesity as an Effect Modifier in Sleep-Disordered Breathing and Postcardiac Surgery Atrial Fibrillation. Chest. 2017 Jun;151(6):1279–1287. doi: 10.1016/j.chest.2017.03.006 Pubmed PMID: 28300569

Mehra R, Bena J, Walia HK. Clarifying the Role of Hypoxia in Obstructive Sleep Apnea as a Potential Promulgator of Atrial Fibrillation in Ischemic Stroke. J Clin Sleep Med. 2017 May 15;13(5):667–668. doi: 10.5664/jcsm.6578 Pubmed PMID: 28416047

Raman D, Kaffashi F, Lui L-Y, Sauer WH, Redline S, Stone P, Cawthon PM, Stone KL, Ensrud KE, Ancoli-Israel S, Loparo K, Mehra R. Polysomnographic Heart Rate Variability Indices and Atrial Ectopy Associated with Incident Atrial Fibrillation Risk in Older Community-dwelling Men. JACC Clin Electrophysiol. 2017 May;3(5):451–460. doi: 10.1016/j.jacep.2016.09.001 Pubmed PMID: 28534047

Mehra R. Building Evidence Implicating Novel Cardiovascular Biomarkers in Obstructive Sleep Apnea. J Clin Sleep Med. 2017 Mar 15;13(3):361–362. doi: 10.5664/jcsm.6476 Pubmed PMID: 28212699

Kapur VK, Auckley DH, Chowdhuri S, Kuhlmann DC, Mehra R, Ramar K, Harrod CG. Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med. 2017 Mar 15;13(3):479–504. doi: 10.5664/jcsm.6506 Pubmed PMID: 28162150

Javaheri S, Barbe F, Campos-Rodriguez F, Dempsey JA, Khayat R, Javaheri S, Malhotra A, Martinez-Garcia MA, Mehra R, Pack AI, Polotsky VY, Redline S, Somers VK. Sleep Apnea: Types, Mechanisms, and Clinical Cardiovascular Consequences. J Am Coll Cardiol. 2017 Feb 21;69(7):841–858. doi: 10.1016/j.jacc.2016.11.069 Pubmed PMID: 28209226

May AM, Van Wagoner DR, Mehra R. OSA and Cardiac Arrhythmogenesis: Mechanistic Insights. Chest. 2017 Jan;151(1):225–241. doi: 10.1016/j.chest.2016.09.014 Pubmed PMID: 27693594

Additional Information