Latest News
Zhang_Xinrui_Deneris Lab

Congratulations to Xinrui Zhang from Deneris lab on her NIH NRSA F30 Predoctoral Fellowship!


neurosciences softball team

Congratulations! Department of Neurosciences Softball Team are the intramural champions!


Recessive loss of function mutations in the FEV (Pet1) gene discovered in autism spectrum disorder cases.

Read the paper here.


Pola

Congratulations to Polyxeni Philippidou for her new NIH R01 Award!


heather crop

Our Own Heather Broihier Earns the National Institutes of Health Landis Award for Outstanding Mentorship!

Click for news details


Dr. Peng Zhang

Dr. Peng Zhang will join us as a new Assistant Professor in April 2020!


Dr. Masashi Tabuchi

Dr. Masashi Tabuchi will join us as a new Assistant Professor in January 2020!


New Undergraduate Neuroscience Courses, Fall 2019!

NEUR301/401

NEUR166

Seminars and Events
Seminar 
Jeffrey Rothstein, M.D., Ph.D.

Jeffrey Rothstein, M.D., Ph.D.

Thursday, November 21, 12:10 - 1:15 pm in BRB 105

Lecture Title: "Disassembly and Reassembly of the Nuclear pore: Origins of ALS/FTD and Target for Therapy"


Adrian Moore, PhD

Adrian Moore, PhD

Friday, November 22, 12:10 – 1:30pm, BRB 105

Seminar Title: "Neuron Differentiation: From Chromatin Control to Dendrite Wiring"


Yackle, Kevin

Kevin Yackle, M.D., Ph.D

Thursday, December 5, 12:10-1:15pm in BRB 105

Lecture Title: "Breathing and Beyond; Lessons learned from molecularly defined respiratory brainstem neurons." 


Suzanne G. Paradis

Suzanne G. Paradis, Ph.D.

Thursday, December 12, 2019, 12:10 pm,  BRB 105

Lecture Title: "Signaling Pathways that Instruct Rapid Changes in Neuronal Connectivity"

Recent Publications
eLife 2019;8:e49180

Neuromuscular junction is a synapse between motoneurons and skeletal muscles to control muscle contraction. Underlying mechanisms of NMJ formation was not well understood. Through studying mutant gene, Rapsyn, implicated in congenital myasthenic syndrome (CMS), the Mei lab uncovered a novel signaling pathway by which Agrin-LRP4-MuSK induces tyrosine phosphorylation of Rapsyn, which is required for its self-association and E3 ligase activity.  

eLife 2019;8:e49180


deneris2019

Ever wonder how long range axonal projections develop? The Deneris lab has uncovered an intrinsic regulatory program that progressively controls the extended multistage formation of long-range expansive axon architectures in the serotonin system. Their latest paper shows that the continuously expressed LIM HD transcription factor, Lmx1b, acts at successive stages to orchestrate the progressive morphological maturation of long-range profusely arborized serotonergic axonal architectures. The findings suggest a potential general regulatory principle of how long range highly arborized axon projection pathways are formed during CNS maturation.

eLife, 2019;8:e48788.


xiong2019_JMCB

Persistent hyperplastic primary vitreous formation (PHPV), a potentially blinding childhood disease, is one of the most common congenital malformation syndromes of the eye, accounting for approximately 5% of blindness in the US. The Xiong lab has discovered that the selective loss of neogenin in neural crest cells, (but not neural stem cells) is sufficient to produce features of the disease in mice. Their latest work suggests a heretofore unknown role for neogenin in neural crest cell regulation.

Journal of Molecular Cell Biology, 23 July 2019