Congratulations! Department of Neurosciences Softball Team are the intramural champions!
Recessive loss of function mutations in the FEV (Pet1) gene discovered in autism spectrum disorder cases.
Congratulations to Polyxeni Philippidou for her new NIH R01 Award!
Our Own Heather Broihier Earns the National Institutes of Health Landis Award for Outstanding Mentorship!
Dr. Peng Zhang will join us as a new Assistant Professor in January 2020!
Dr. Masashi Tabuchi will join us as a new Assistant Professor in January 2020!
New Undergraduate Neuroscience Courses, Fall 2019!
Seminar
Amanda J. Law, Ph.D.
Thursday, October 17th, 12:10 – 1:10pm
Lecture Title: "Mechanisms of Genetic Risk for Schizophrenia: Focus on Akt signaling and Developmental Origins"
Xin Duan, PhD
Thursday, October 31st, 12:10 - 1:10 pm BRB 105
Lecture Title: "Molecular Mechanisms Regulating Visual Circuit Wiring"
Young-Jin Son, PhD
Thursday, November 7th, 4:00 – 5:00pm, SOM, Robbins, E501
Lecture Title: "Sensory axon regeneration across the CNS-PNS border"
Neuromuscular junction is a synapse between motoneurons and skeletal muscles to control muscle contraction. Underlying mechanisms of NMJ formation was not well understood. Through studying mutant gene, Rapsyn, implicated in congenital myasthenic syndrome (CMS), the Mei lab uncovered a novel signaling pathway by which Agrin-LRP4-MuSK induces tyrosine phosphorylation of Rapsyn, which is required for its self-association and E3 ligase activity.
Ever wonder how long range axonal projections develop? The Deneris lab has uncovered an intrinsic regulatory program that progressively controls the extended multistage formation of long-range expansive axon architectures in the serotonin system. Their latest paper shows that the continuously expressed LIM HD transcription factor, Lmx1b, acts at successive stages to orchestrate the progressive morphological maturation of long-range profusely arborized serotonergic axonal architectures. The findings suggest a potential general regulatory principle of how long range highly arborized axon projection pathways are formed during CNS maturation.
Persistent hyperplastic primary vitreous formation (PHPV), a potentially blinding childhood disease, is one of the most common congenital malformation syndromes of the eye, accounting for approximately 5% of blindness in the US. The Xiong lab has discovered that the selective loss of neogenin in neural crest cells, (but not neural stem cells) is sufficient to produce features of the disease in mice. Their latest work suggests a heretofore unknown role for neogenin in neural crest cell regulation.
Journal of Molecular Cell Biology, 23 July 2019
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