Alterations in homeostatic mechanisms of the brain can lead to various neurological disorders including autism, schizophrenia, epilepsy, etc. Changes in synapse number, proteins involved in synaptogenesis, and axon outgrowth may lead to imbalances in excitation and inhibition, and improper connectivity between specific brain regions. Recent studies have identified alterations in microglia leading to detrimental effects on the pruning process of both synapses, neural progenitor cells, and more recently, oligodendrocytes. Dr. Nemes is interested in the relationship between cellular dysfunction in development and neurological disorders throughout the lifespan including epilepsy, brain injury and repair, Alzheimer's Disease, and demyelinating disorders. By understanding the underlying mechanisms of neurodevelopment, we can provide new insights into early diagnosis, prevention, and treatment of neurological disorders in both development and adulthood.
1. Nemes-Baran, A.D., White, D.R., DeSilva, T.M. Fractalkine-Dependent Microglial Pruning of Viable Oligodendrocyte Progenitor Cells Regulates Myelination Cell Reports, 32(7): 108047.
2. Zhou, Q-G., Nemes, A., Lee, D., Ro, E.J., Zhang, J., Nowacki, A., Dymecki, S., Najm I., Suh, H. (2019) Chemogenetic silencing of hippocampal neurons suppresses epileptic neural circuits. Journal of Clinical Investigation, 129(1):310-323.
3. Zhou, Q-G, Zhu, X-H, Nemes, A.D., Zhu, D-Y. (2018). Neuronal Nitric Oxide Synthase and Affective Disorders. International Brain Research Organization Reports, 5, 116-132.
4. Adewole, D.O., Struzyna, L.A., Harris, J.P., Nemes, A.D., Burrell, J.C., Petrov, D., Kraft, R.H., Chen, H.I., Wolf, J.A., Serruya, M.D., Cullen, D.K. (2018). Optically-Controlled 'Living Electrodes' with Long-Projecting Axon Tracts for a Synaptic Brain-Machine Interface. SSRN Electronic Journal, http://dx.doi.org/10.2139/ssrn.3189383.
5. Liu, M-Y., Nemes, A., Zhou, Q-G. (2018). The Emerging Roles for Telomerase in the Central Nervous System. Frontiers in Molecular Neuroscience, 11:160.
6. Nemes, A.D., Ayasoufi, A., Ying, Z., Zhou, Q.G., Suh, H., Najm, I.M. (2017). Growth Associated Protein 43 (GAP-43) as a Novel Target for the Diagnosis, Treatment and Prevention of Epileptogenesis. Scientific Reports, 7(1): 17702.
7. Serruya, M.D., Harris, J.P., Adewole, D.O, Struzyna, L.A., Burrell, J.C., Nemes, A., Petrov, D., Kraft, R.H., Chen, H.I., Wolf, J.A., Cullen, D.K. (2017). Engineered Axonal Tracts as “Living Electrodes” for Synaptic‐Based Modulation of Neural Circuitry. Advanced Functional Materials, doi: 10.1002/adfm.201701183
8. Nemes, A.D., O’Dwyer, R., Najm, I.M., Ying, Z., Gonzalez-Martinez, J., Alexopoulos, A. (2017). Treatment with Lacosamide impedes generalized seizures in rodent model of cortical dysplasia. Epilepsia, 58(10): 1755-1761.
9. Nemes, A., Najm, I., Gale, J.T., Ying, Z., Johnson, M., Gonzalez-Martinez, J. (2016). Underlying cortical dysplasia as risk factor for traumatic epilepsy: An animal study. Journal of Neurotrauma, 33(20): 1883-1891.
10. Ying, Z., Najm, I., Nemes, A., Pinheiro-Martins, A.P., Alexopoulos, A., Gonzalez-Martinez, J., Bingaman, W. (2014). Growth-associated protein 43 and progressive epilepsy in cortical dysplasia. Annals of Clinical and Translational Neurology, 1-9.