Explore our grant funding in the Carpenter Lab in the Departments of Medicine and Pathology at Case Western Reserve University School of Medicine.
ACTIVE PROJECTS
Evaluating human T cells specific for Mycobacterium tuberculosis antigens that are processed and presented by infected macrophages.
Grant Number: R01 AI187662
Funding Date: 8/01/2025 – 7/31/2030
Grant Funder: NIH/NIAID
Participant and Role: Carpenter (PI)
The major goals of this project are to determine the Mycobacterium tuberculosis antigens presented by infected macrophages and the antigen-specific TCR clonotypes elicited during the early response to infection in people living in an area endemic for TB.
Determining protective features of human memory T cells to inform Mycobacterium tuberculosis vaccine development.
Grant Number: K08 AI163407
Funding Date: 8/11/2022 – 7/31/2027
Grant Funder: NIH/NIAID
Participant and Role: Carpenter (PI)
The major goals of this project are to determine the frequency, functions and antigen specificity of memory CD4 T cells that are able to recognize and respond to Mtb-infected macrophages.
Human T cell recognition of macrophages infected with Mycobacterium tuberculosis early after IGRA.
Grant Number: Innovation Award 1267638
Funding Date: 7/1/2024 – 6/30/2026
Grant Funder: American Lung Association
Participant and Role: Carpenter (PI)
The major goals of this project are to determine the TCR repertoire and functions of T cells that respond to Mtb-infected macrophages in the blood and lungs of Mtb-infected individuals living in a TB endemic setting.
COMPLETED PROJECTS
Overcoming restrained lung trafficking by memory CD4+ T cells to prevent active TB in people living with HIV.
Grant Number: R21 AI167675
Funding Date: 8/5/2022 – 7/31/2025 (NCE)
Grant Funder: NIH/NIAID
Participant and Role: Carpenter, Freeman (co-PIs)
This project proposes to identify the functional differences in T cell responses to latent Mtb infection among HIV+ and HIV- individuals to further our understanding for why those with HIV are more likely to develop active TB despite having CD4 counts > 500.
Protective attributes of Mycobacterium tuberculosis-specific human lung resident memory CD4 T cells.
Grant Number: Catalyst Award 924107
Funding Date: 7/1/2022 – 6/30/2024
Grant Funder: American Lung Association
Participant and Role: Carpenter (PI)
Identification of the functional differences in circulating and lung resident memory T cell responses to latent Mtb infection among individuals at higher vs. lower risk of developing active TB.