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Publications

Researchers in the Carpenter Lab regularly publish their work. Take a look at recent research manuscripts from our team in the Departments of Medicine and Pathology at Case Western Reserve University School of Medicine.

Recent Research Manuscripts

  1. Gail DP, Suzart VG, Carpenter SM. Analyzing human CD4+ T cells activated in response to macrophages infected with Mycobacterium tuberculosis. STAR Protoc. 2024 Mar 6;5(1):102939. doi: 10.1016/j.xpro.2024.102939. Epub ahead of print. PMID: 38451821.
  2. Swartz TH, Apewokin S, Carpenter SM, Chakraborty R, Dennis AM, Houpt E, Surana NK, Zerr DM, Pirofski LA. A Call to Action: Urgently Strengthening the Future Physician-Scientist Workforce in Infectious Diseases. J Infect Dis. 2024 Mar 14;229(3):625-629. doi: 10.1093/infdis/jiad610. PMID: 38309710.
  3. Mwebaza I, Shaw R, Li Q, Fletcher S, Achkar JM, Harding CV, Carpenter SM, Boom WH. Impact of Mycobacterium tuberculosis Glycolipids on the CD4+ T Cell-Macrophage Immunological Synapse. J Immunol. 2023 Nov 1;211(9):1385-1396. doi: 10.4049/jimmunol.2300107. PMID: 37695687; PMCID: PMC10579150.
  4. Gail DP, Suzart VG, Du W, Kaur Sandhu A, Jarvela J, Nantongo M, Mwebaza I, Panigrahi S, Freeman ML, Canaday DH, Boom WH, Silver RF, Carpenter SM. Mycobacterium tuberculosis impairs human memory CD4+ T cell recognition of M2 but not M1-like macrophages. iScience. 2023 Aug 23;26(9):107706. doi: 10.1016/j.isci.2023.107706. PMID: 37694142; PMCID: PMC10485162.
  5. Tkachev V, Vanderbeck A, Perkey E, Furlan SN, McGuckin C, Gómez Atria D, Gerdemann U, Rui X, Lane J, Hunt DJ, Zheng H, Colonna L, Hoffman M, Yu A, Outen R, Kelly S, Allman A, Koch U, Radtke F, Ludewig B, Burbach B, Shimizu Y, Panoskaltsis-Mortari A, Chen G, Carpenter SM, Harari O, Kuhnert F, Thurston G, Blazar BR, Kean LS, Maillard I. (2023). Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates. Sci Transl Med. 2023 Jun 28;15(702):eadd1175. doi: 10.1126/scitranslmed.add1175. Epub 2023 Jun 28. PMID: 37379368.
  6. Carpenter, S. M. & Bold, T. D. How Do I Navigate Latent Tuberculosis Diagnosis? Nejm Évid 1, (2022). https://doi.org/10.1056/EVIDccon2200125.
  7. Carpenter S.M., Lu L.L. (2022). Leveraging Antibody, B Cell and Fc Receptor Interactions to Understand Heterogeneous Immune Responses in Tuberculosis. Front Immunol. 2022 Mar 17;13:830482. https://doi.org/10.3389/fimmu.2022.830482. PMID: 35371092.
  8. Sutiwisesak R., Hicks N.D., Boyce S., Murphy, K.C., Papavinasasundaram K., Carpenter, S.M., Boucau J., Joshi N., Le Gall S., Fortune, S.M., Sassetti, C.M., Behar, S.M. (2020). A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response. PLoS Pathog 16(10): e1009000. https://doi.org/10.1371/journal.ppat.1009000. PMID: 33075106
  9. Yang J.D., Mott D., Sutiwisesak R., Lu Y-J., Raso F., Stowell B., Babunovic, G.H., Lee, J., Carpenter S.M., Way, S.S., Fortune, S.M., Behar, S.M. (2018) Mycobacterium tuberculosis-specific CD4+ and CD8+ T cells differ in their capacity to recognize infected macrophages. PLoS Pathog 14(5): e1007060. https://doi.org/10.1371/journal.ppat.1007060. 
  10. Carpenter, S.M., & Behar, S. M. (2018). A new vaccine for tuberculosis in rhesus macaques. Nature Medicine, 24(2), 124–126. http://doi.org/10.1038/nm.4488.
  11. Carpenter S.M., Yang J.D., Lee J., Barreira-Silva P., Behar S.M. (2017) Vaccine-elicited memory CD4+ T cell expansion is impaired in the lungs during tuberculosis. PLoS Pathog 13(11): e1006704. https://doi.org/10.1371/journal. ppat.1006704.  
  12. Booty MG, Barreira-Silva P, Carpenter S.M., Nunes-Alves C., Jacques M.K., Stowell B.L., Jayaraman P., Beamer G., Behar S.M. (2016). IL-21 signaling is essential for optimal host resistance against Mycobacterium tuberculosis infection. Scientific Reports, 11(6):36720. PMID: 27819295. 
  13. Booty, MG., Nunes-Alves, C., Carpenter S.M., Jayaraman P., & Behar S. M. (2016). Multiple Inflammatory Cytokines Converge To Regulate CD8+ T Cell Expansion and Function during Tuberculosis. The Journal of Immunology, 196(4), 1822–1831. PMID: 26755819.
  14. Carpenter, S.M., Nunes-Alves, C., Booty, M. G., Way, S. S., & Behar, S. M. (2016). A Higher Activation Threshold of Memory CD8+ T Cells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis. PLoS Pathog 12(1), e1005380. PMID: 26745507.
  15. Nishimura, T., Fujita-Suzuki, Y., Mori, M., Carpenter, S. M., Fujiwara, H., Uwamino, Y., Tamizo E., Tano I., Kawabe H., Hasegawa N. (2016). Middle-aged to elderly women have a higher asymptomatic infection rate with Mycobacterium avium complex, regardless of body habitus. Respirology (Carlton, Vic.), 21(3):553-5. PMID: 26639819.
  16. Nunes-Alves, C., Booty, M. G., Carpenter, S. M., Rothchild, A. C., Martin, C. J., Desjardins, D., Steblenko K, Kløverpris HN, Madansein R, Ramsuran D, Leslie A, Correia-Neves M, Behar SM (2015). Human and Murine Clonal CD8+ T Cell Expansions Arise during Tuberculosis Because of TCR Selection. PLoS Pathog 11(5), e1004849. PMID: 25945999.
  17. Behar, S. M., Carpenter, S. M., Booty, M. G., Barber, D. L., & Jayaraman, P. (2014). Orchestration of pulmonary T cell immunity during Mycobacterium tuberculosis infection: immunity interruptus. Seminars in Immunology, 26(6), 559–577. PMID: 25311810.
  18. Nunes-Alves, C., Booty, M. G., Carpenter, S. M., Jayaraman, P., Rothchild, A. C., & Behar, S. M. (2014). In search of a new paradigm for protective immunity to TB. Nature Reviews Microbiology, 12(4), 289–299. PMID: 24590243. 

Discover more publications through the Carpenter Lab.