Sponsor: U.S. National Institutes of Health (UO1-AI69501)
Michael Lederman, MD, Principal Investigator, CWRU; Robert A. Salata, MD, Co-Investigator, CWRU
|Type of Study / Description||Conduct HIV clinical trials at U.S. and international research sites|
Overview of ACTG
The AIDS Clinical Trials Group, funded by the U.S. National Institutes of Health, Division of AIDS, is the world's largest HIV clinical trials organization, playing a lead role in defining standards of care for treatment of HIV infection and opportunistic diseases related to HIV/AIDS around the world.
ACTG is made up of multiple committees that direct and oversees all activities. ACTG is governed by the Executive Committee (AEC), that is ultimately responsible for all scientific, administrative, and fiscal decisions on behalf of the Network. The AEC oversees (through the activities of the Scientific Agenda Steering Committee) the scientific direction and research agendas of the ACTG and is responsible for oversight of all clinical trials activities and timely analysis and dissemination of study results. The AEC develops and implements bylaws, policies, and procedures of the network. Through the Performance Evaluation Committee (PEC), the AEC establishes standards of performance for the OPS, the SDMC, the Scientific and Resource Committees, the Network Laboratories (NL), and the Clinical Trials Units (CTUs) and Clinical Research Sites (CRSs). The AEC oversees the allocation of resources of the Core, including distributions for the specialty laboratories, the OPS, the Scientific and Resource Committees, the Network Community Advisory Board (NCAB), overhead accounts, and pharmaceutical supplemental and discretionary funds. The AEC also makes decisions and recommendations to DAIDS regarding the allocation of protocol implementation funds and annual budget allocations made to each of the ACTG-affiliated CTUs/CRSs based on site performance evaluations.
CWRU and Uganda Clinical Trials Units
The CWRU site, under the leadership of Dr. Michael Lederman, and the Joint Clinical Research Centre in Uganda are both active Clinical Trials Units via the ACTG international network. Both units conduct multiple ACTG clinical trials, as is most feasible and beneficial for the available patient populations at the sites.
For further information about the AIDS Clinical Trials Unit at CWRU/University Hospitals Cleveland Medical Center.