Center for AIDS Research

Sponsor - U.S. National Institutes of Health (P30-AI36219)
Principal Investigator - Jonathan Karn, PhD, CWRU; Co-Investigators - W. Henry Boom, MD, CWRU; Immaculate Nankya, PhD, CWRU/Uganda

Type of Study / Description Core infrastructure support for HIV clinical and laboratory activities, improving resources for HIV funded research studies
Interactions Collaborating investigators/staff, utilizing shared infrastructure; provides HIV core clinical and laboratory-based services and support for TB-HIV research at CWRU and in Uganda

Overview of CFAR

The Case Western Reserve University/University Hospitals Center For AIDS Research (CFAR) has been continually funded since its initiation in April 1994 as one of 11 such centers of excellence established by the U.S. National Institutes of Health. The CFAR has a mandate to coordinate basic and clinical research activities and to promote interdisciplinary research in HIV infection and AIDS. Comprising more than 140 faculty researchers at the Schools of Medicine, Nursing, Arts and Sciences, and Law, the CFAR provides core resources, seminars, lectureships, publications and developmental funding to promote and strengthen the AIDS research programs at the University and its affiliated institutions. CFAR membership includes scientist and clinicians from Case, University Hospitals of Cleveland, MetroHealth Medical Center, The Cleveland Veterans Administration Center and the Cleveland Clinic Foundation. Current key areas of research strength include a) international aspects of AIDS; b) AIDS clinical research; c) HIV immunology; d) molecular virology; e) mycobacterial disease; f) AIDS-related malignancies; and g) HIV prevention.

One of the positive benefits of the CFAR is the uniting of basic scientists working on AIDS with their clinical colleagues. Since its founding in 1994, the Case CFAR has been dedicated to coordinating an ever-expanding spectrum of AIDS-related activities. Major strengths of the Case CFAR include clinical and translational research, international research, and in training young researchers, both on a national and international level. In Cleveland, a close, dynamic relationship between the CFAR and the NIH-funded AIDS Clinical Trials Unit (a collaboration between UHC, MetroHealth, the Cleveland Clinic, and the Joint Clinical Research Centre/Uganda-CWRU Research Collaboration), assists in fulfilling these institutions mandates as centers of excellence and providers of the highest quality patient care. On the international front, a long-standing scientific relationship with Makerere University in Kampala, Uganda, has culminated in establishing sophisticated CFAR laboratories in Uganda at the Joint Clinical Research Centre, providing support for AIDS-related research in Africa.

Uganda Laboratory Core Services

Extensive laboratory services are available as a service through the Uganda Laboratory Core. Services are available to Ugandan researchers and physicians as well as other funded researchers or clinical project leaders in Uganda. Core services include:

  1. Molecular virology and HIV drug resistance testing
  2. Immunology
  3. Bacteriology and STD testing

The Case CFAR works actively with other Case centers and departments in areas of mutual interest. In addition to the AIDS Clinical Trials Unit, these include the Comprehensive Cancer Center (AIDS-related malignancies, studies of immune restoration), the Tuberculosis Research Unit (HIV/TB interactions), the Skin Diseases Research Center Center for Medical Mycology (CMM-opportunistic fungal infections), the Center for Global Health and Disease (international research), the EpID Center (epidemiology/biostatistics, international research), and the Department of Biomedical Ethics and the Law-Medicine Center (Ethics of AIDS Research and Care Research Program).