Long-term TB Resister Study

Long-term resistance to latent Mycobacterium tuberculosis infection (RV-19)


Sponsor - U. S. National Institutes of Health
Principal Investigators – W. Henry Boom, MD and Catherine Stein, PhD, CWRU; Harriet Mayanja-Kizza, MBChB, MMed, PhD, Uganda-CWRU Research Collaboration

Type of Study

Prospective Observational Cohort Study


Observational Cohort Study

Project Site

Kampala, Uganda


Ugandan participants 15 years of age or greater

Participants with MTB resistant or stable latent TB infection phenotype

HIV-infected and HIV-uninfected participants

Sample Size

300 expected to be enrolled

Study Period

2019 - Current

Participants will “roll-over” to this study, as TB resistant participants and stable LTBI controls are identified

Participants will remain on study for approximately 6 years


To enroll and follow healthy participants/household contracts of TB patients identified from our prior and current research studies in Kampala, Uganda. Resister participants are those who have consistently tested negative for Mycobacterium tuberculosis (MTB) infection for more than 24 months. Participants with stable latent MTB infection (LTBI) will serve as controls. Continued follow-up of these cohorts will strengthen the evidence of a “resister” (RSTR) phenotype and a true biological resistance to infection that provides a unique cohort for further studies of Mycobacterium tuberculosis (MTB).

Objectives of Study:

  1. To maintain contact with, and assess MTB infection status over time in MTB resistant and MTB latently infected participants
  2. To assess the effects of HIV-infection on the stability of MTB infection status over time
  3. To explore associations between general health/demographic metrics and long-term stability of MTB resistance in a Ugandan population