Kawempe Community Health Study

Information:

DMID Protocol Number: 01-005

Sponsor - U. S. National Institutes of Health
Principal Investigators – W. Henry Boom, MD, CWRU; Harriet Mayanja-Kizza, MBChB, MMed., PhD, Uganda-CWRU Research Collaboration

Type of Study Observational Household Contact Study
Design Hybrid Cross-sectional / Cohort
Project Site Kawempe Division and adjacent parishes in Kampala, Uganda
Sample Size 3818 subjects with clinically active tuberculosis per year and their households enrolled (ongoing follow-up only)
Population

Adults with a culture confirmed, initial case of clinically active tuberculosis and members of their households with active TB, TB infection, and exposure but no infection

First degree relatives of adults with a culture confirmed, initial case of clinically active tuberculosis

Study Period 2002-Present

Goal of Study:

An overarching goal of the TBRU is to develop and implement a systematic and multidisciplinary approach towards furthering scientific understanding of the epidemiology, microbiology, immunology and host genetics of MTB infection and disease in populations with a high prevalence of disease. The Household Contact Study provides a framework for assessing the risk of infection with MTB and of developing active TB, for evaluating innovative methods for prevention, diagnosis and treatment, and for assessing the burden of disease in a community with a high prevalence of TB.

Objectives of Study:

  1. To determine critical host factors associated with primary MTB infection, re-infection, reactivation, and progression of clinical disease
  2. To identify and track individual strains of MTB through Ugandan households and local community