DMID Protocol Number: 01-005
Sponsor - U. S. National Institutes of Health
Principal Investigators – W. Henry Boom, MD, CWRU; Harriet Mayanja-Kizza, MBChB, MMed., PhD, Uganda-CWRU Research Collaboration
|Type of Study||Observational Household Contact Study|
|Design||Hybrid Cross-sectional / Cohort|
|Project Site||Kawempe Division and adjacent parishes in Kampala, Uganda|
|Sample Size||3,818 participants enrolled, including 982 index cases with clinically active TB, 2,784 household contacts and 52 first degree relatives (completed)|
Adults with a culture confirmed, initial case of clinically active tuberculosis and members of their households with active TB, TB infection, and exposure but no infection
First degree relatives of adults with a culture confirmed, initial case of clinically active tuberculosis
Goal of Study:
An overarching goal of the TBRU is to develop and implement a systematic and multidisciplinary approach towards furthering scientific understanding of the epidemiology, microbiology, immunology and host genetics of MTB infection and disease in populations with a high prevalence of disease. The Household Contact Study provided a framework for assessing the risk of infection with MTB and of developing active TB, for evaluating innovative methods for prevention, diagnosis and treatment, and for assessing the burden of disease in a community with a high prevalence of TB.
Objectives of Study:
- To determine critical host factors associated with primary MTB infection, re-infection, reactivation, and progression of clinical disease
- To identify and track individual strains of MTB through Ugandan households and local community
The results of this completed study can be found in:
Stein CM, Zalwango S, Malone LL, Thiel B, Mupere E, Nsereko M, Okware B, Kisingo H, Lancioni CL, Bark CM, Whalen CC, Joloba ML, Boom WH, Mayanja-Kizza H. Resistance and susceptibility to Mycobacterium Tuberculosis infection and disease. Am J. Epidemoil. 2018; 187:1477-1489. PMCID: PMC6031055.
Stein CM, Nsereko M, Malone LL, Okware B, Kisingo H, Nalukwago S, Chervenak K, Mayanja-Kizza H, Hawn TR, Boom WH. Long-term stability of resistance to Latent Mycobacterium tuberculosis infection in highly exposed tuberculosis household contacts in Kampala, Uganda. Clin Infect Dis. 2019; 68:1705-1712. PMCID: PMC6495009.
Luzze H, Johnson DF, Dickman K, Mayanja-Kizza H, Okwera A, Eisenach K, Cave MD, Whalen CC, Johnson JL, Boom WH, Joloba M; Tuberculosis Research Unit. Relapse more common that reinfection in recurrent tuberculosis 1-2 years post treatment in urban Uganda. Int J Tuberc Lung Dis. 2013; 17:361-367. PMCID: PMC6623981