Resistance to Latent Mycobacterium Tuberculosis Infection (RL-15)
DMID Protocol Number: 15-0093
Sponsor - U. S. National Institutes of Health
Principal Investigators – W. Henry Boom, M.D., CWRU; Harriet Mayanja-Kizza, M.B.Ch.B., M.Med., Ph.D., Uganda-CWRU Research Collaboration
|Type of Study||Prospective Observational Household Contact Study|
|Design||Hybrid Cross-sectional / Cohort Study|
|Project Site||Kampala, Uganda|
Ugandan adults, age 15 years or greater, who live in Kampala, Uganda with an individual with active TB disease and do not show signs and symptoms of TB disease themselves
Total participants - 800
2015 - Current
Projected time to enroll participants is 4 years. Projected time to complete study is 5 years. Individual participant duration of follow-up is 12 months after enrollment.
Goal of Study:
The goal of this study is to identify and further define TST/quantiferon concordant TB resister phenotype and their concordant LTBI controls.
Objectives of Study:
To recruit a new cohort of persons who resist infection with Mycobacterium tuberculosis (MTB) and expand earlier studies on this important phenotype.
To examine epidemiologic and host genetic, genomic, and immunologic factors associated with the RSTR phenotype.