Miklos Gratzl, PhD

Associate Professor
Department of Biomedical Engineering
Case School of Engineering, School of Medicine

Research Information

Research Interests

Development and biomedical application of chemical sensing schemes is the focus of my laboratory. Diagnostics in 1-20 microliter body fluids and other samples is performed using micro fabricated electrochemical and optical sensors and an electrochemical micro-pH-stat. We also developed an equivalent of rotating electrode for microliter samples, called the rotating sample system. For cellular research, a diffusional microburet has been developed to continuously deliver reagents and drugs into single live cells. Fluorescence microscopy is employed to quantitate intracellular accumulation. Efflux is measured with a carbon fiber based electrochemical microsensor that can detect Adriamycin, a cancer drug, extruded from cells at very low concentrations. Neurochemical studies as well as measurements at epithelial cell layers are also performed with different microscopic sensing schemes.


  • Potdar AA, Sarkar J, Das NK, Gosh P, Gratzl M, Fox PL, Saidel GM: Computational modeling and analysis of iron release from macrophages. PLOS Computations Biology 12: 243-267 (2014)
  • Ahuja P, Peshkova MA, Hemphill B, Gratzl M: Minimizing color interference from biomedical samples in optode-based measurements. Sensors and Actuators II Chemical (12): 212-216 (2014)
  • Ahuja P, Nair S, Narayan S, Gratzl M: Functional imaging of chemically active surfaces with optical reporter microbeads. 10(9), PPLOS ONE (2015)

Full list of Publications

Additional Information