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  4. Steven Eppell

Steven Eppell, PhD

Associate Professor
Department of Biomedical Engineering
Case School of Engineering
School of Medicine
Director
Nanoscale Orthopedic Biomaterials Laboratory - NOBL

Research Information

Research Interests

The Nanoscale Orthopedic Biomaterials Laboratory I direct has two main thrusts. First, we develop instrumentation, models, and techniques that bridge the gap from the atomic to the microscale. We wish to map properties like static charge, dipole moments, and electronic polarizability onto measured three dimensional molecular structures. To make this information useful, we develop techniques that utilize these enriched structural images in the creation of models intended to predict assembly of supramolecular structures as well as the mechanics of these structures. This approach is designed to yield insight into a host of biologically relevant problems ranging from enzyme-substrate interactions to design and synthesis of novel biomaterials to whole tissue mechanics. Second, we utilize biomimetic strategies to design and synthesize orthopedic biomaterials. Most of the work on this thrust has involved determining the nanoscale design constraints of natural bone and tendon. Recently, we have transitioned to synthesizing and testing synthetic bone and tendon materials based on these constraints.

Publications

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  • Miller, E., Pokorski, J., Palomo, L., & Eppell, S. (2020). A Bottom-Up Approach Grafts Collagen Fibrils Perpendicularly to Titanium Surfaces. ACS Applied Bio Materials, 3 (9), 6088-6095.
  • Saez, P., Eppell, S., Ballarini, R., & Rodriguez Matas, J. (2020). A complementary energy approach accommodates scale differences in soft tissues. Journal of the Mechanics and Physics of Solids, 138
  • Eppell, S., Friedenberg, D., Payton, O., Picco, L., & Zypman, F. (2020). Euler-Bernoulli theory accurately predicts atomic force microscope cantilever shape during non-equilibrium snap-to-contact motion.. Nanotechnology, 31 (18), 185702.
  • Ferreira JPS, Kuang, M., Parente MPL, M., Jorge RMN, M., Wang, R., Eppell, S., & Damaser, M. (2020). Altered mechanics of vaginal smooth muscle cells due to the lysyl oxidase-like1 knockout.. Acta biomaterialia.
  • Varghai, K., Wang, R., & Eppell, S. (2020). Effect of Drilling Speed on Dental Implant Insertion Torque.. The Journal of oral implantology.
  • Li , L., Eppell, S., & Zypman, F. (2020). Method to Quantify Nanoscale Surface Charge in Liquid with Atomic Force Microscopy.. Langmuir : the ACS journal of surfaces and colloids, 36 (15), 4123-4134.
  • Eppell, S., Tong, W., McMasters, J., Soenjaya, Y., Barbu, A., Ko, A., & Baskin, J. (2018). Minor Review: An Overview of a Synthetic Nanophase Bone Substitute. Materials, 11 (9).
  • Baskin, J., Soenjaya, Y., McMasters, J., Ko, A., Vasanji, A., Morris, N., & Eppell, S. (2018). Nanophase bone substitute for craniofacial load bearing application: Pilot study in the rodent: NANOPHASE BONE SUBSTITUTE FOR CRANIOFACIAL LOAD BEARING APPLICATION. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 106 (2), 520-532.
  • Baskin, J., Soenjaya, Y., McMasters, J., Ko, A., Vasanji, A., Morris, N., & Eppell, S. (2017). Nanophase bone substitute for craniofacial load bearing application: Pilot study in the rodent: NANOPHASE BONE SUBSTITUTE FOR CRANIOFACIAL LOAD BEARING APPLICATION. Journal of Biomedical Materials Research - Part B Applied Biomaterials.
  • Eppell, S., Feinstein, M., Liu, L., White, B., & Zypman, F. (2017). Signal distortion in atomic force microscopy photodetector. Review of Scientific Instruments, 88 (10).
  • Eppell, S., Liu, L., & Zypman, F. (2017). Unexplored territory in the AFM force curve contains nanomechanics information. AIP Advances, 7 (10).
  • Liu, Y., Andarawis-Puri, N., & Eppell, S. (2016). Method to extract minimally damaged collagen fibrils from tendon.. Journal of biological methods, 3 (4), e54.
  • Wang, R., Eppell, S., Nguyen, B., & Morrison, I. (2016). Relative Contribution of Trabecular and Cortical Bone to Primary Implant Stability: An In Vitro Model Study.. The Journal of oral implantology, 42 (2), 145-52.
  • Eppell, S., Liu, Y., & Zypman, F. (2016). Accuracy of AFM force distance curves via direct solution of the Euler-Bernoulli equation. AIP Advances [21583226], 6 (3).
  • Liu, Y., Ballarini, R., & Eppell, S. (2016). Tension tests on mammalian collagen fibrils. Interface Focus [20428898], 6 (1).
  • Abel, P., Eppell, S., Walker, A., & Zypman, F. (2015). Viscosity of liquids from the transfer function of microcantilevers. , 61 , 67-74.
  • Zypman, F., & Eppell, S. (2013). Electrostatic force curves in finite-size-ion electrolytes.. Langmuir : the ACS journal of surfaces and colloids, 29 (38), 11908-14.
  • Baskin, J., & Eppell, S. (2013). A selected review of the recent advances in craniomaxillofacial bone tissue engineering.. Current opinion in otolaryngology & head and neck surgery, 21 (4), 389-95.
  • Baskin, J., Vasanji, A., McMasters, J., Soenjaya, Y., Barbu, A., & Eppell, S. (2012). Nanophase bone substitute in vivo response to subcutaneous implantation.. Journal of biomedical materials research. Part A, 100 (9), 2462-73.
  • Shen, X., Kahn, H., Ballarini, R., & Eppell, S. (2011). Viscoelastic properties of isolated collagen fibrils.. Biophysical journal, 100 (12), 3008-15.
  • Jarmusik, K., Eppell, S., Lacks, D. J., & Zypman, F. J. (2011). Obtaining charge distributions on geometrically generic nanostructures using scanning force microscopy.. Langmuir : the ACS journal of surfaces and colloids, 27 (5), 1803-10.
  • Kang, M., Wang, Q., Eppell, S., & Doerschuk, C. (2010). Effect of neutrophil adhesion on the mechanical properties of lung microvascular endothelial cells.. American journal of respiratory cell and molecular biology, 43 (5), 591-8.
  • Shen, X., Dodge, M., Kahn, H., Ballarini, R., & Eppell, S. (2010). In vitro fracture testing of submicron diameter collagen fibril specimens.. Biophysical journal, 99 (6), 1986-95.
  • Tang, Y., Ballarini, R., Buehler, M., & Eppell, S. (2010). Deformation micromechanisms of collagen fibrils under uniaxial tension.. Journal of the Royal Society, Interface, 7 (46), 839-50.
  • Shen, X., Dodge, M., Kahn, H., Ballarini, R., & Eppell, S. (2008). Stress-strain experiments on individual collagen fibrils.. Biophysical journal, 95 (8), 3956-63.
  • Kang, M., Panneerselvam, D., Panoskaltsis, V., Eppell, S., & Doerschuk, C. (2008). Changes in the hyperelastic properties of endothelial cells induced by tumor necrosis factor-alpha.. Biophysical journal, 94 (8), 3273-85.
  • Katz, J., Misra, A., Spencer, P., Wang, Y., Bumrerraj, S., Nomura, T., Eppell, S., & Tabib-Azar, M. (2007). Multiscale mechanics of hierarchical structure/property relationships in calcified tissues and tissue/material interfaces.. Materials science & engineering. A, Structural materials : properties, microstructure and processing, 27 (3), 450-468.
  • Eppell, S., Smith, B., Kahn, H., & Ballarini, R. (2006). Nano measurements with micro-devices: mechanical properties of hydrated collagen fibrils.. Journal of the Royal Society, Interface, 3 (6), 117-21.
  • Todd, B., & Eppell, S. (2004). Probing the limits of the Derjaguin approximation with scanning force microscopy.. Langmuir : the ACS journal of surfaces and colloids, 20 (12), 4892-7.
  • Vasanji, A., Ghosh, A., Graham, L., Eppell, S., & Fox, P. (2004). Polarization of plasma membrane microviscosity during endothelial cell migration.. Developmental cell, 6 (1), 29-41.
  • Todd, B., Rammohan, J., & Eppell, S. (2003). Connecting nanoscale images of proteins with their genetic sequences.. Biophysical journal, 84 (6), 3982-91.
  • Tong, W., Glimcher, M., Katz, J., Kuhn, L., & Eppell, S. (2003). Size and shape of mineralites in young bovine bone measured by atomic force microscopy.. Calcified tissue international, 72 (5), 592-8.
  • Ghosh, A., Vasanji, A., Murugesan, G., Eppell, S., Graham, L., & Fox, P. (2002). Membrane microviscosity regulates endothelial cell motility.. Nature cell biology, 4 (11), 894-900.
  • Tong, W., & Eppell, S. (2002). Control of surface mineralization using collagen fibrils.. Journal of biomedical materials research, 61 (3), 346-53.
  • Kang, M., Sit, P., Zhou, Y., Todd, B., Eppell, S., & Lee, K. (2002). Molecular views and measurements of hemostatic processes using atomic force microscopy.. Current protein & peptide science, 3 (3), 249-74.
  • Eppell, S., Tong, W., Katz, J., Kuhn, L., & Glimcher, M. (2001). Shape and size of isolated bone mineralites measured using atomic force microscopy.. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 19 (6), 1027-34.
  • LaBarbera, M., Shainoff, J., Eppell, S., Wilson, D. L., & Siedlecki, C. L. (1997). Three dimensional structure of human fibrinogen under aqueous conditions visualized by atomic force microscopy.. Thrombosis and haemostasis, 77 (6), 1048-51.
  • LaBarbera, M., Shainoff, J., Eppell, S., Wilson, D. L., & Siedlecki, C. L. (1997). Three dimensional structure of human fibrinogen under aqueous conditions visualized by atomic force microscopy.. Thrombosis and haemostasis, 77 (6), 1048-51.
  • Siedlecki, C., Lestini, B., Kottke-Marchant, K., Eppell, S., & Wilson, D. L. (1996). Shear-dependent changes in the three-dimensional structure of human von Willebrand factor.. Blood, 88 (8), 2939-50.
  • Siedlecki, C., Lestini, B., Kottke-Marchant, K., Eppell, S., & Wilson, D. L. (1996). Shear-dependent changes in the three-dimensional structure of human von Willebrand factor.. Blood, 88 (8), 2939-50.
  • Wilson, D. L., Dalal, P. L., Kump, K. L., Benard, W. L., Xue, P. L., & Eppell, S. L. (1996). Morphological modeling of atomic force microscopy imaging including nanostructure probes and fibrinogen molecules. Journal of Vacuum Science & Technology B, 14 (4), 2407-2416.
  • Eppell, S., Simmons, C., & Albrecht, R. (1995). Cell-surface receptors and proteins on platelet membranes imaged by scanning force microscopy using immunogold contrast enhancement.. Biophysical journal, 68 (2), 671-80.
  • Wilson, D. L., Kump, K. L., & Eppell, S. L. (1995). Morphological Restoration of Atomic-Force Microscopy Images. Langmuir, 11 (1), 265-272.
  • Siedlecki, C., & Eppell, S. (1994). Interactions of human von Willebrand factor with a hydrophobic self-assembled monolayer studied by atomic force microscopy.. Journal of Biomedical Materials Research, 28 (9), 971-80.

Full list of Publications

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Education

Other
Biomedical Engineering
Case Western Reserve University
1994
PhD
Experimental Condensed Matter Physics
Case Western Reserve University
1991
Bachelor of Arts
Physics
Carleton College
1984

Additional Information