Research Assistant Professor, Department of Biomedical Engineering, Case School of Engineering
Member, Cancer Imaging Program, Case Comprehensive Cancer Center
Member, CWRU Center for Imaging Research
Develops imaging agent for detection and photodynamic therapy of cancer cells and tissue that would allow the surgeon to decide in real time how aggressive the surgical intervention need be.
Research Information
Research Interests
Dr. Walker has long performed experimental and clinical research with a particular focus on the role of the local inflammatory microenvironment in carcinogenesis of the thyroid, prostate, and mammary glands. His research involves basic, translational, and clinical areas of biomedicine. In this basic research the focus is to understand the role of chronic inflammation, cancer stem cells, and immune response in cancer development and metastasis with the aim to develop appropriate biomarkers for early photo-theranostics and prognosis.
Publications
- Walker, E., Turaga, S., Wang, X., Ramamurthy, G., Shukla, S., Basilion, J., & Lathia, J. (2021). Development of Near-Infrared Imaging Agents for Detection of Junction Adhesion-Molecule A Protein.. Translational Oncology, 14 (3), 101007.
- Wang, X., Shirke, A., Walker, E., Sun, R., Ramamurthy, G., Wang, J., Shan, L., Mangadlao, J., Dong, Z., Wang, Z., Liu, H., Schluchter, M., Luo, D., Wang, Y., Stauffer, S., Brady-Kalnay, S., Hoimes, C., Lee, Z., & Basilion, J. (2021). Small-Molecule-Based Prodrug Targeting Prostate Specific Membrane Antigen for the Treatment of Prostate Cancer.. Cancers, 13 (3), 417.
- Luo, D., Wang, X., Walker, E., Wang, J., Springer, S., Lou, J., Ramamurthy, G., Burda, C., & Basilion, J. (2020). Nanoparticle Yield Increased Drug Uptake and Therapeutic Efficacy Upon Sequential Near-Infrared Irradiation. ACS Nano, 14 , 15193-15203.
- Walker, E., Liu, Y., Kim, S., Biro, M., Iyer, N., Ezaldein , H., Scott, J., Merati, M., Mistur , R., Zhou, B., Straight, B., Yim, J., Bogyo, M., Crescimanno, M., Wilson, D. L., Basilion, J. L., & Popkin, D. L. (2020). A Protease-Activated Fluorescent Probe Allows Rapid Visualization of Keratinocyte Carcinoma during Excision.. Cancer research.
- Walker, E., Ramamurthy, ., Shirke, A., Mangadlao , J., Wang, Z., & Basilion, J. (2019). Photodynamic Therapy as an Effective Adjuvant After Image-Guided Surgery of Prostate Tumor. Cancer Research.
- Walker, E., Iyer, S., Biro, M., Kim, I., Zhou, B., Bogyo, M., Basilion, J., Popkin, D., & Wilson, D. (2019). Molecular Imaging and Validation of Margins in Surgically Excised Nonmelanoma Skin Cancer Specimens. Journal of Molecular Imaging.
- Liu, Y., Walker, E., Iyer, N., Biro, M., Kim, S., Zhou, B., Straight, B., Bogyo, M., Basilion, J., Popkin, D., & Wilson, D. L. (2019). Molecular imaging and validation of margins in surgically excised nonmelanoma skin cancer specimens.. Journal of medical imaging (Bellingham, Wash.), 6 (1), 016001.
- Liu, Y., Walker, E., Iyer, N., Biro, M., Kim, S., Zhou, B., Straight, B., Bogyo, M., Basilion, J., Popkin, D., & Wilson, D. L. (2019). Molecular imaging and validation of margins in surgically excised nonmelanoma skin cancer specimens.. Journal of medical imaging (Bellingham, Wash.), 6 (1), 016001.
- Walker, E., Shukla, S., & Gupta, S. (2018). Acquisition of tumorigenic potential and therapeutic resistance in CD133+ subpopulation of prostate cancer cells exhibiting stem-cell like characteristics. Cancer Letters, 430 , 25-33.
- Walker, E., Mann, M., Honda, K., Vidimos, A., Schluchter, M., Straight, B., Bogyo, M., Popkin, D., & Basilion, J. (2017). Rapid Visualization of nonmelanoma skin cancer. Journal Am. Acad. Dermatolorgy, 76 (2), 209-216.e9.
- Walker, E., Basilion, J., Gopalakrishnan , R., & Bogyo, M. (2014). Microscopic detection of quenched activity based optical imaging probes using an antibody detection system: localizing protease activity. Molecular Imaging and Biology, 5 , 608-618.
Education
PhD
Medicine/Clinical Immunology
Institute of Tuberculosis & Pulmonology of the Academy of Medical Science of Ukraine, Kyiv, Ukraine
1999
MD(magna cum laude)
Pediatrics
Kyiv Medical Institute, Kyiv, Ukraine
1992
PA
Medicine
Kyiv Medical College #2, Kyiv, Ukraine
1983